supported by the National Natural Science Foundation of China,No.62276089。
Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human brain.To enable learning by brain and machine,it is essential to accurately identify and correct the pr...
supported by the Massachusetts General Hospital Scientific Projects to Accelerate Research and Collaboration (SPARC) award;Cure Alzheimer’s Fund (to CZ);the National Institutes of Health (NIH),including R01NS102190,RF1NS120947,and R01HL161253 (to MBW),RF1NS120947 (to RJT)。
Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primari...
supported by grants from the Academy of Finland#293392,#319195;Päivikki and Sakari Sohlberg Foundation(to AD);Polish National Science Centre grant 2019/35/D/NZ7/03200-Sonata 15(to PC).
Parkinson’s disease(PD)is the second most common neurodegenerative disorder characterized by multiple motor and nonmotor symptoms,which include,among others,constipation,sleep disturbance,bradykinesia,gait and balanc...
The axon initial segment(AIS)region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels(Nav).Nav channels comprise several serine residues responsib...
grants from CNPq (Universal 2012; INCT-Excitotoxicity and Neuroprotection);FAPESC (NENASC/PRONEX);CAPES (PVE 052/2012) to C.I.T
Excitotoxicity refers to toxicity caused by abnormal concentrations of glutamate in the synaptic cleft that may lead to neuronal death. Since its description, the phenomenon of glutamatergic excitotoxicity has been im...