supported by the Japan Science and Technology Agency-Precursory Research for Embryonic Science and Technology (JPMJPR22SA to MM);Japan Society for the Promotion of Science KA KENHI Grant-in-Aid for Scientific Research(JP21K07309 to HT,JP20H05688 and JP22K19365 to KN);Takeda Science Foundation (to KN);Keio Gijuku Academic Development Funds (to KN);Keio Gijuku Fukuzawa Memorial Fund (to KN)
The cerebral cortex is comprised of properly localized cell types that exert their specific functions.In the developing brain,cells migrate from the germinal region to their functional locations(Silva et al.,2019;Coss...
Several major factors are known to contribute to CNS axon regenerative failure after injury, including reduced intrinsic growth capacity of developed neurons and extrinsic factors mediating axon outgrowth. For the lat...
Spinal cord injury(SCI)causes disturbances in motor and sensory functions leading to paralysis,the severity of which depends on the spinal level of the injury.Traumatic lesions of spinal cord axon projection tracts ...
funded by NIH R01 NS085426(VJT);the Craig H.Neilsen Foundation(DW)
Spinal cord injury(SCI)is a traumatic event that can lead to permanent motor and sensory deficits.After the initial trauma,axons of surviving neurons rapidly retract.While there may be a small degree of abortive spr...
supported by grants from NIH/ NINDS (R01NS054734);the California Institute for Regenerative Medicine;the Craig H. Neilsen Foundation and Wings for Life Spinal Cord Research Foundation
The limited axonal growth after central nervous system (CNS) injury such as spinal cord injury presents a major challenge in promoting repair and recovery. The literature in axonal repair has focused mostly on frank...