BACKGROUND Diazoxide is the sole approved drug for congenital hyperinsulinism;however,diuretic administration and vigilant monitoring are crucial to prevent and promptly identify potentially life-threatening adverse e...
The study was funded by National Key Research and Development Program of China(2016YFC1305304);Beijing Children's Hospital Young Investigator Program(No.BCHYIPA-2016-06);Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support(No.ZYLX201821).
Importance: Octreotide is an off-label medicine for congenital hyperinsulinism (CHI), but is currently widely used for treatment of patients with CHI. Thus far, variable efficacy and adverse effects have been reported...
AIM: To study the effects of indomethacin on the isolated transverse and longitudinal rat gastric fundus strips.METHODS: The strips were suspended in an organ bath containing oxygenated Krebs solution, and contractile...
Backgroud Recent studies in adult hearts have indicated that K ATP channels in the inner mitochondrial membrance are responsible for the protection. And we investigated whether opening of mitochondrial K ATP ...