SPHINGOSINE

作品数：80被引量：236H指数：8
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相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Approach to loss of response to advanced therapies in inflammatory bowel disease被引量：1
《World Journal of Gastroenterology》2024年第22期2902-2919,共18页Nikil Vootukuru Abhinav Vasudevan 
BACKGROUND Remarkable progress over the last decade has equipped clinicians with many options in the treatment of inflammatory bowel disease.Clinicians now have the unique opportunity to provide individualized treatme...
关键词：Inflammatory bowel disease Ulcerative colitis CROHN BIOLOGICS Interleukin-12 and interleukin-23 inhibitors Alpha-beta7-integrin inhibitors Janus kinase inhibitors Sphingosine-1-phosphate receptor modulators 
Unveiling the biological role of sphingosine-1-phosphate receptor modulators in inflammatory bowel diseases被引量：4
《World Journal of Gastroenterology》2023年第1期110-125,共16页Evanthia Tourkochristou Athanasia Mouzaki Christos Triantos 
Inflammatory bowel disease(IBD)is chronic inflammation of the gastrointestinal tract that has a high epidemiological prevalence worldwide.The increasing disease burden worldwide,lack of response to current biologic th...
关键词：Inflammatory bowel disease Sphingosine-1-phosphate Intestinal inflammation T helper 1/T helper 17 Sphingosine 1 phosphate Modulators Immune responses 
Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells被引量：6
《World Journal of Gastroenterology》2015年第46期13055-13063,共9页Yan-Chang Lei Ling-Ling Yang Wen Li Pan Luo Pei-Fen Zheng 
Supported by the National Natural Science Foundation of China;No.81160065
AIM: To determine the therapeutic potential of sphingosine kinase 1(Sphk1) inhibition and its underlying mechanism in a well-characterized mouse model of D-galactosamine(D-Gal N)/lipopolysaccharide(LPS)-induced acute ...
关键词：Acute liver failure SPHINGOSINE KINASE 1 High-mobi 
Sphingosine kinase 1 dependent protein kinase C-δ activation plays an important role in acute liver failure in mice被引量：1
《World Journal of Gastroenterology》2015年第48期13438-13446,共9页Yan-Chang Lei Ling-Ling Yang Wen Li Pan Luo 
Supported by The National Natural Science Foundation of China;No.81160065
AIM: To investigate the role of protein kinase C(PKC)-δ activation in the pathogenesis of acute liver failure(ALF) in a well-characterized mouse model of D-galactosamine(D-Gal N)/lipopolysaccharide(LPS)-induced ALF.M...
关键词：ACUTE liver failure Protein KINASE C-δ SPHINGOSINE KINASE 1 NUCLEAR factor-κB 
New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury被引量：2
《World Journal of Gastroenterology》2015年第45期12778-12786,共9页Naoki Sano Takafumi Tamura Naoyuki Toriyabe Takeshi Nowatari Ken Nakayama Tomohito Tanoi Soichiro Murata Yu Sakurai Mamoru Hyodo Kiyoshi Fukunaga Hideyoshi Harashima Nobuhiro Ohkohchi 
Supported by Ministry of Education;Culture;Sports;Science;and Technology of Japan;KAKENHI;No.23390319
AIM: To investigate the cytoprotective effects in hepatic ischemia-reperfusion injury, we developed a new formulation of hyaluronic acid(HA) and sphingosine 1-phophate.METHODS: We divided Sprague-Dawley rats into 4 gr...
关键词：Hyaluronic ACID SPHINGOSINE 1-phosphate LIVER sinu 
Advances in the management of peritoneal mesothelioma被引量：15
《World Journal of Gastroenterology》2014年第33期11700-11712,共13页Ali Raza Wei-Ching Huang Kazuaki Takabe 
Supported by United States National Institute of Health(to Kazuaki Takabe),No.R01CA160688;Investigator Initiated Research Grant(to Susan G Komen),No.IIR12222224
Malignant peritoneal mesothelioma(PM) is an infrequent disease which has historically been associated with a poor prognosis. Given its long latency period and non-specific symptomatology, a diagnosis of PM can be sugg...
关键词：Peritoneal mesothelioma MESOTHELIOMA Hyperthermic intraperitoneal chemotherapy Cytore-duction Sphingosine kinase Sphingosine-1-phosphate FTY720 
STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer被引量：10
《World Journal of Gastroenterology》2014年第30期10279-10287,共9页Andrew V Nguyen Yuan-Yuan Wu Elaine Y Lin 
Accumulated evidences have demonstrated that signal transducer and activator of transcription 3(STAT3)is a critical link between inflammation and cancer.Multiple studies have indicated that persistent activation of ST...
关键词：Sphingosine-1-phosphate Signal transducer and activator of transcription 3 INTERLEUKIN-6 INFLAMMATION Colorectal cancer TUMORIGENESIS Tumor progression Inflammatory bowel disease 
Effect of S1P5 on proliferation and migration of human esophageal cancer cells被引量：8
《World Journal of Gastroenterology》2010年第15期1859-1866,共8页Hu, Wei-Min Li, Li Ing, Bao-Qian Zhao, Yong-Sheng Wang, Chao-Li Feng, Li Xie, Yong-En 
Supported by The Key Project of Ministry of Education, No. 209105;Sichuan Youth Science and Technology Foundation, No. 08ZQ026-081;Key Laboratory Foundation of North Sichuan Medical College, No. KFJJ (08)-03
AIM:To investigate the sphingosine 1phosphate (S1P) receptor expression profile in human esophageal cancer cells and the effects of S1P5 on proliferation and migration of human esophageal cancer cells. METHODS: S1P re...
关键词：Sphingosine 1phosphate Esophageal cancer Sphingosine 1phosphate 5 PROLIFERATION MIGRATION 
Alphastatin downregulates vascular endothelial cells sphingosine kinase activity and suppresses tumor growth in nude mice bearing human gastric cancer xenografts被引量：7
《World Journal of Gastroenterology》2006年第26期4130-4136,共7页Lin Chen Tao Li Rong Li Bo Wei Zheng Peng 
AIM： To investigate whether alphastatin could inhibit human gastric cancer growth and furthermore whether sphingosine kinase （SPK） activity is involved in this process. METHODS： Using migration assay, MTT assay an...
关键词：Stomach neoplasm Angiogenesis Endothelial cells Sphingosine kinase Cancer therapy 
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