supported by National Key Research&Development Program from the Ministry of Science and Technology of the PRC(No.2019YFE0111800,China);National Natural Science Foundation of China(No.81872923,China);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-JKCS-016,China);The Science and Technology Development Fund,Macao SAR(No.0074/2019/AMJ,China).
Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease with unclear etiology and limited treatment options.The median survival time for IPF patients is approximately 2–3 years and there is no effective inter...
National Research Initiative Competitive Grant No.2009-35203-05725(KJB and GAJ);Fellowship No.2008-35203-18830(KAD)from the USDA National Institute of Food and Agriculture.
Background:The lysosphingolipid,sphingosine-1-phosphate,is a well-described and potent pro-angiogenic factor.Receptors,as well as the sphingosine phosphorylating enzyme sphingosine kinase 1,are expressed in the placen...
Supported by United States National Institute of Health(to Kazuaki Takabe),No.R01CA160688;Investigator Initiated Research Grant(to Susan G Komen),No.IIR12222224
Malignant peritoneal mesothelioma(PM) is an infrequent disease which has historically been associated with a poor prognosis. Given its long latency period and non-specific symptomatology, a diagnosis of PM can be sugg...
Infiltration of myelin-specific helper T (Th) cells into the central nervous system (CNS) plays a key role in pathogenesis of experimental autoimmune encephalomyelitis (EAE). In this study, we investigated the involve...
Therapeutic administration of fingolimod hydrochloride (FTY720), the functional antagonist at sphingosine 1-phosphate (S1P) receptor 1 (S1P1) shows a marked improving effect on experimental autoimmune encephalomyeliti...