SPHINGOSINE

作品数:80被引量:236H指数:8
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相关领域:医药卫生更多>>
相关作者:张翼肖琼尹大力徐美林王菁更多>>
相关机构:北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金:国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung被引量:3
《Acta Pharmaceutica Sinica B》2023年第3期1110-1127,共18页Mengyao Hao Rong Fu Jun Tai Zhenhuan Tian Xia Yuan Yang Chen Mingjin Wang Huimin Jiang Ming Ji Fangfang Lai Nina Xue Liping Bai Yizhun Zhu Xiaoxi Lv Xiaoguang Chen Jing Jin 
supported by National Key Research&Development Program from the Ministry of Science and Technology of the PRC(No.2019YFE0111800,China);National Natural Science Foundation of China(No.81872923,China);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-JKCS-016,China);The Science and Technology Development Fund,Macao SAR(No.0074/2019/AMJ,China).
Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease with unclear etiology and limited treatment options.The median survival time for IPF patients is approximately 2–3 years and there is no effective inter...
关键词:Idiopathic pulmonary fibrosis Endothelial barrier Tight junction Sphingosine-1-phosphate receptor 1 Sphingosine-1-phosphate receptor 1 agonist FTY720 IMMH002 Protein stability 
FTY720,a sphingosine analog,altered placentome histoarchitecture in ewes
《Journal of Animal Science and Biotechnology》2020年第2期380-392,共13页Kathrin A.Dunlap Bryan G.White David W.Erikson M.Carey Satterfield Christiane Pfarrer Guoyao Wu Fuller W.Bazer Robert C.Burghardt Kayla J.Bayless Greg A.Johnson 
National Research Initiative Competitive Grant No.2009-35203-05725(KJB and GAJ);Fellowship No.2008-35203-18830(KAD)from the USDA National Institute of Food and Agriculture.
Background:The lysosphingolipid,sphingosine-1-phosphate,is a well-described and potent pro-angiogenic factor.Receptors,as well as the sphingosine phosphorylating enzyme sphingosine kinase 1,are expressed in the placen...
关键词:Placentome Pregnancy SHEEP Sphingosine1 phosphate(S1P) 
Advances in the management of peritoneal mesothelioma被引量:15
《World Journal of Gastroenterology》2014年第33期11700-11712,共13页Ali Raza Wei-Ching Huang Kazuaki Takabe 
Supported by United States National Institute of Health(to Kazuaki Takabe),No.R01CA160688;Investigator Initiated Research Grant(to Susan G Komen),No.IIR12222224
Malignant peritoneal mesothelioma(PM) is an infrequent disease which has historically been associated with a poor prognosis. Given its long latency period and non-specific symptomatology, a diagnosis of PM can be sugg...
关键词:Peritoneal mesothelioma MESOTHELIOMA Hyperthermic intraperitoneal chemotherapy Cytore-duction Sphingosine kinase Sphingosine-1-phosphate FTY720 
Role of Sphingosine 1-Phosphate (S1P) Receptor 1 in Experimental Autoimmune Encephalomyelitis —I
《Pharmacology & Pharmacy》2013年第8期628-637,共10页Noriyasu Seki Yasuhiro Maeda Hirotoshi Kataoka Kunio Sugahara Kenji Chiba 
Infiltration of myelin-specific helper T (Th) cells into the central nervous system (CNS) plays a key role in pathogenesis of experimental autoimmune encephalomyelitis (EAE). In this study, we investigated the involve...
关键词:SPHINGOSINE 1-Phosphosphate RECEPTOR 1 FINGOLIMOD Hydrochloride (FTY720) Experimental Autoimmune ENCEPHALOMYELITIS Th1 CELLS Th17 CELLS 
Role of Sphingosine 1-Phosphate (S1P) Receptor 1 in Experimental Autoimmune Encephalomyelitis —II
《Pharmacology & Pharmacy》2013年第8期638-646,共9页Noriyasu Seki Hirotoshi Kataoka Kunio Sugahara Atsushi Fukunari Kenji Chiba 
Therapeutic administration of fingolimod hydrochloride (FTY720), the functional antagonist at sphingosine 1-phosphate (S1P) receptor 1 (S1P1) shows a marked improving effect on experimental autoimmune encephalomyeliti...
关键词:SPHINGOSINE 1-Phosphosphate RECEPTOR 1 FINGOLIMOD Hydrochloride (FTY720) Experimental Autoimmune ENCEPHALOMYELITIS Astrocytes PRO-INFLAMMATORY Cytokines 
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