FINGOLIMOD

作品数：20被引量：35H指数：3
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相关领域：医药卫生更多>>
相关作者：江春平屈振强光辉李尔广张广更多>>
相关机构：天津医科大学南京大学医学院附属鼓楼医院南京大学锦州医科大学更多>>
相关期刊：《World Journal of Meta-Analysis》《化工管理》《广东药科大学学报》《药学进展》更多>>
相关基金：国家自然科学基金辽宁省科学技术计划项目辽宁省教育厅高等学校科学研究项目中国博士后科学基金更多>>
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Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury被引量：5
《Neural Regeneration Research》2023年第4期869-874,共6页Xiao-Yu Zhu Ting-Ting Ma Yang Li Ming-Qi Zhang Liang Zhao Jia Liang Lian-Qiu Min 
supported by grants from the National Natural Science Foundation of China,No.81971231(to JL);Liaoning Revitalization Talents Program,No.XLYC1907178(to JL)。
Recent research on the underlying mechanisms of cerebral ischemia indicates that the neurovascular unit can be used as a novel subject for general surveys of neuronal damage and protein mechanisms.Fingolimod(FTY-720)i...
关键词：astrocyte blood-brain barrier CLAUDIN-5 FTY-720 INTERLEUKIN-17A ischemic stroke neural protection neurovascular unit OCCLUDIN sphingosine-1-phosphate receptor 1 
Early-life fingolimod treatment improves intestinal homeostasis and pancreatic immune tolerance in non-obese diabetic mice被引量：2
《Acta Pharmacologica Sinica》2021年第10期1620-1629,共10页Ling-ling Jia Ming Zhang He Liu Jia Sun Li-long Pan 
This work was supported by funds from the National Natural Science Foundation of China(Grant Nos.80270666,81870439,81901670,81973322,and National Youth 1000 Talents Plan);the Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province(Grants No.:BK20200026);the Recruitment Plan for High-level,Innovative and Entrepreneurial Talents(innovative Research Team)of Jiangsu Province,the Jiangsu Province Qing Lan Project,Jiangsu Province"Six Summit Talents"program(Grant No.2019-YY-038);the collaborative innovation center of food safety and quality control in Jiangsu Province,National First-Class Discipline Program of Food Science and Technology(Grant No.JUFSTR20180103);Wuxi Social Development Funds for International Science&Technology Cooperation(Grant No.WX0303B010518180007PB);the Fundamental Research Funds for the Central Universities(Grant Nos.:81870439 and JUSRP22007);Chinese Postdoctoral Science Foundation(Grant No.2018M642169);Jiangsu Postdoctoral Research Foundation(Grant No.2018K237C);Wuxi Taihu Talent Project.
Fingolimod has beneficial effects on multiple diseases,including type 1 diabetes(T1D)and numerous preclinical models of colitis.Intestinal dysbiosis and intestinal immune dysfunction contribute to disease pathogenesis...
关键词：FINGOLIMOD type 1 diabetes gut barrier enteric pathogens TLR2-NF-κB-NLRP3 
Efficacy and safety of fingolimod in stroke:A systemic review and meta-analysis
《World Journal of Meta-Analysis》2021年第6期585-597,共13页Kai Zhao Yu Guo Ming-Fei Yang Qiang Zhang 
BACKGROUND Brain tissue injury in stroke patients involves inflammation around the infarction lesion or hematoma,which is an important reason for disease deterioration and can result in a poor prognosis.The meta-analy...
关键词：Acute ischemic stroke Intracerebral hemorrhage FINGOLIMOD META-ANALYSIS TREATMENT 
芬戈莫德(FTY720)通过激活Nrf2/HO-1通路促进大鼠脑缺血再灌注损伤后神经功能恢复被引量：5
《细胞与分子免疫学杂志》2021年第5期415-420,共6页伍慧茹 张磊 黄美伊 王奕丹 王建楠 隋汝波 
国家自然科学基金(81371461,81241050);辽宁省教育厅科学研究项目(JYTJCZR201903);辽宁省科学技术计划项目(2019-ZD-0802)。
目的研究芬戈莫德(FTY720/fingolimod)对脑缺血再灌注损伤的治疗作用并探索其保护机制。方法60只SD大鼠随机分为假手术组、脑缺血再灌注损伤(MCAO/R)模型组及FTY720组。MCAO/R组和FTY720组用Longa缝合法建立MCAO/R模型。采用改良神经功...
关键词：芬戈莫德(FTY720/fingolimod) 脑缺血/再灌注 核因子E2相关因子2(Nrf2) 氧化应激 炎症反应 
Fingolimod(FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging被引量：2
《Neural Regeneration Research》2020年第7期1308-1315,共8页Jie Zhang Bin Xiao Chen-Xu Li Yi Wang 
supported by the National Natural Science Foundation of China,No.81500932(YW)
Neurocognitive dysfunction is a common postoperative complication,especially in older adult patients.Fingolimod(FTY720)is a sphingosine-1-phosphate receptor modulator that has been found to be neuroprotective in sever...
关键词：D-GALACTOSE fengomod(FTY720) HEPATECTOMY MICROGLIA nerve regeneration postoperative neurocognitive dysfunction SEVOFLURANE 
美国FDA首次批准芬戈莫德(Fingolimod)仿制药
《广东药科大学学报》2019年第6期818-818,共1页夏训明(编译) 
诺华公司(Novartis)治疗复发性多发性硬化症药物Gilenya(fingolimod,芬戈莫德,CAS登记号162359 55 9)胶囊专利到期,美国FDA于2019年12月5日宣布一次性同时批准3家制药公司生产其仿制药(通用药名Generics),用于成人治疗复发性多发性硬化...
关键词：芬戈莫德 仿制药 制药公司 登记号 美国FDA 通用药名 诺华公司 
芬戈莫德的合成工艺进展
《化工管理》2016年第21期115-,共1页刘魏 
芬戈莫德为鞘氨醇-1-磷酸受体调节剂,成为首个被FDA批准可经口给药的用于治疗复发-缓解型多发性硬化症,本文就其合成方法进行综述,为医药开发提供参考。
关键词：芬戈莫德 合成 氨基丙二醇 FINGOLIMOD 
Fingolimod对小鼠慢性胰腺纤维化的抑制作用
《中国中西医结合外科杂志》2016年第3期261-264,共4页崔立华 张淑坤 卓玉珍 李彩霞 张一 刘洪斌 崔乃强 
天津市卫生局基金(2013KY27)
目的:观察新型免疫抑制剂Fingolimod(FTY720)对雨蛙素致小鼠慢性胰腺纤维化的治疗作用。方法:健康雄性C57BL/6小鼠30只,随机分为对照组、模型组和FTY720治疗组。模型组和治疗组腹腔注射雨蛙素,50μg·kg^(-1)·次^(-1),1周3次,连续6周;...
关键词：FTY720 胰腺纤维化 雨蛙素 调节性T细胞 
Fingolimod alters inflammatory mediators and vascular permeability in intracerebral hemorrhage被引量：14
《Neuroscience Bulletin》2015年第6期755-762,共8页Yu-Jing Li Guo-Qiang Chang Yuanchu Liu Ye Gong Chunsheng Yang Kristofer Wood Fu-Dong Shi Ying Fu Yaping Yan 
supported by the National Basic Research Development Program of China (2013CB966900);the National Natural Science Foundation of China (81241144, 81371372);the National Key Clinical Specialty Construction Program of China
Intracerebral hemorrhage （ICH） leads to high rates of death and disability. The pronounced inflammatory reactions that rapidly follow ICH contribute to disease progression. Our recent clinical trial demonstrated tha...
关键词：FINGOLIMOD inflammatory mediator vascular permeability intracerebral hemorrhage 
溶血磷脂受体调节因子芬戈莫德:从传统中药到FDA批准药物(英文)
《中国药理学与毒理学杂志》2015年第S1期1-1,共1页Jerold CHUN 
Lysophospholipids are small,membrane-derived lipids that act through a growing family of G protein-coupled receptors(GPCRs)that account for around 40% of the known lipid GPCRs.They comprise a range of distinct chemica...
关键词：FINGOLIMOD LYSOPHOSPHOLIPID receptor MODULATOR TRA 
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