ALLOSTERY

作品数：11被引量：20H指数：3
导出分析报告
相关领域：生物学理学更多>>
相关作者：苏晓东更多>>
相关机构：北京大学更多>>
相关期刊：《Journal of Biosciences and Medicines》《Quantitative Biology》《Science China Chemistry》《Science Bulletin》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
选择条件：
  • 期刊=Cell Researchx
共 条 记 录，以下是1-3
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Self-made allostery: endogenous COMP antagonizes pathologic AT1_(A)R signaling
《Cell Research》2021年第7期730-731,共2页Ama Dedo Okyere Douglas G.Tilley 
The identification and development of biased modulators of proximal G protein-coupled receptor(GPCR)signaling to prevent pathological disease progression has been at the forefront of recent drug discovery efforts.Rece...
关键词：ENDOGENOUS AT1 COMP 
Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating被引量：2
《Cell Research》2018年第12期1158-1170,共13页Guizhen Fan Mariah R. Baker Zhao Wang Alexander B. Seryshev Steven J. Ludtke Matthew L. Baker Irina I. Serysheva 
the National Institutes of Health (ROIGM072804,R21AR063255,R21NS106968, ROIGM080139,P41GM103832,American Heart Association (16GRNT2972000);Muscular Dystrophy Association (295138);National Science Foundation (DBI-1356306).
Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are cation channels that mobilize Ca2+ from intracellular stores in response to a wide range of cellular stimuli.The paradigm of InsP3R activation is the coupled interp...
关键词：CRYO-EM REVEALS LIGAND ALLOSTERY UNDERLYING InsP3R channel GATING 
Structural insights into Ca^2＋-activated long-range allosteric channel gating of RyR1被引量：5
《Cell Research》2016年第9期977-994,共18页Risheng Wei Xue Wang Yan Zhang Saptarshi Mukherjee Lei Zhang Qiang Chen Xinrui Huang Shan Jing Congcong Liu Shuang Li Guangyu Wang Yaofang Xu Sujie Zhu Alan J Williams Fei Sun Chang-Cheng Yin 
Acknowledgments We thank Dr Anthony Lai （Wales Heart Research Institute, Cardiff University School of Medicine, UK） for advice and suggestions during the course of this research and critically reading this manuscript. This research was supported by grants from the Strategic Priority Research Program of Chinese Academy of Sciences （XDB08030202 to FS）, the National Basic Research Program （973 Program）, the Ministry of Science ＆ Technology of China （Programs 2012CB917200 to CCY and 2014CB910700 to FS）, the National Natural Science Foundation of China （31270768 to CCY） and the Ministry of Education of China （111 Program China to CCY）. All the cryo-EM work and all the intensive computations were performed at Centre for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences （CBI, http：//cbi.ibp.ac.cn）, with the help from Drs Xiaojun Huang and Lunjiang Lin.
Ryanodine receptors （RyRs） are a class of giant ion channels with molecular mass over 2.2 mega-Daltons. These channels mediate calcium signaling in a variety of cells. Since more than 80% of the RyR protein is folde...
关键词：Ca^2＋ activation cryo-electron microscopy channel gating ion selectivity long-range allostery ryanodine receptor single-particle analysis 
全选清除导出
共1页<1>
检索报告 对象比较 聚类工具 使用帮助 返回顶部