双链断裂

作品数：379被引量：1098H指数：12
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Spontaneous DNA damage propels tumorigenicity
《Cell Research》2017年第6期720-721,共2页Ilio Vitale Guido Kroemer 
High levels of endogenously gen- erated DNA damage drive oncogen- esis, sustain malignant progression and increase therapy resistance. In a paper recently published in Cell Research, Liu and colleagues added additiona...
关键词：DNA损伤 损伤机制 双链断裂 性基因 侵袭性 恶性 细胞 
H1 provides the missing link
《Cell Research》2016年第1期5-6,共2页Michael SY Huen Junjie Chen 
Adding to the Histone Code at DNA double-strand breaks, Mailand and colleagues now uncover non- degradative ubiquitin marks on linker histone HI as key signaling intermediates in the DNA damage signal transduction cas...
关键词：DNA双链断裂 组蛋白密码 信号转导通路 DNA损伤 信号分子 泛素 
DNA damage and repair regulate neuronal gene expression
《Cell Research》2015年第9期993-994,共2页Yijing Su 
Neuronal activity-induced gene expression is crucial for the development and plasticity of the brain and for learning and memory. In a recent study published in Cell, Madabhushi et al. report that neuronal activity tr...
关键词：基因表达 神经元 修复 损伤 CELL 双链断裂 可塑性 记忆 
diRNA-Ago2-RAD51 complexes at double-strand break sites被引量：3
《Cell Research》2014年第5期511-512,共2页Soichiro Yamanaka Haruhiko Siomi 
The way in which the DNA damage response signals the presence of DNA lesions and mediates DNA repair has not been fully elucidated. Now, Gao et al. reveal that diRNA-Ago2 complexes recruit RAD51 to the break sites.
关键词：双链断裂 DNA损伤 网站 DNA修复 应答信号 GAO 复合物 
Efficient genome editing in plants using a CRISPR/Cas system被引量：228
《Cell Research》2013年第10期1229-1232,共4页Zhengyan Feng Botao Zhang Wona Ding Xiaodong Liu Dong-Lei Yang Pengliang Wei Fengqiu Cao Shihua Zhu Feng Zhang Yanfei Mao Jian-Kang Zhu 
Dear Editor, In the past few years, the development of sequence- specific DNA nucleases has progressed rapidly and such nucleases have shown their power in generating efficient targeted mutagenesis and other genome e...
关键词：CAS系统 基因组 编辑 植物 DNA双链断裂 DNA结合结构域 非编码RNA DNA核酸 
Targeted mutagenesis in rice using CRISPR-Cas system被引量：115
《Cell Research》2013年第10期1233-1236,共4页Jin Miao Dongshu Guo Jinzhe Zhang Qingpei Huang Genji Qin Xin Zhang Jianmin Wan Hongya Gu Li-Jia Qu 
Genome editing of model organisms is essential for gene function analysis and is thus critical for human health and agricultural production. The current technolo- gies used for genome editing include ZFN （zinc-finger...
关键词：CAS系统 定向诱变 模式生物基因组 水稻 DNA双链断裂 非同源末端连接 基因功能分析 重复序列 
Meiotic DSBs and the control of mammalian recombination
《Cell Research》2012年第12期1624-1626,共3页Kenneth Paigen Petko Petkov 
The laboratories of Galina Petuk- hova and R Daniel Camerini-Otero have achieved significant technical advances in determining the genomewide sites of DNA double-strand breaks （DSBs） where the process of genetic exc...
关键词：DNA双链断裂 减数分裂 哺乳动物 重组 控制 技术进步 基因交流 分裂过程 
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