supported by the National Natural Science Foundation of China(82027802,82171304,82071466,81771260,81871022,82071468,and 82201618);“Sail Plan”Key Medical Specialty(ZYLX202139);“Mission”Talent Project of Beijing Municipal Administration of Hospitals(SML20150802);Beijing Municipal Science and Technology Project(Z181100001918026);Technological Innovation and Service Capability Construction Project From Beijing Municipal Commission of Education(11000023T000002157177)。