云南高校图书馆联盟文献共享服务平台- 肿瘤抑制基因

肿瘤抑制基因: 作品数：1033被引量：2417H指数：17; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：王立东吴浩强彭颂先傅松滨唐婉君更多>>; 相关机构：第二军医大学哈尔滨医科大学复旦大学中国医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家高技术研究发展计划更多>>

Clinical and molecular characteristics of East Asian patients with von Hippel–Lindau syndrome被引量：3: 《Chinese Journal of Cancer》2016年第9期441-446,共6页Meihua Wong Ying-Hsia Chu Hwei Ling Tan Hideharu Bessho Joanne Ngeow Tiffany Tang Min-Han Tan; Background: Von Hippel–Lindau(VHL) syndrome is a dominantly inherited multisystem cancer syndrome caused by a heterozygous mutation in the VHL tumor suppressor gene. Previous studies suggested that similar population...; 关键词：临床特征综合征分子特征东亚患者基因突变肿瘤抑制基因表型特征

Recent progress in the study of methylated tumor suppressor genes in gastric cancer被引量：4: 《Chinese Journal of Cancer》2013年第1期31-41,共11页Xiao-Tong Hu Chao He; supported by grants from National Natural Science Foundation of China(No.30770920 and 81071651);Zhejiang Provincial Natural Science Foundation of China(No.R2100213,2009C33142,Z2090056 and WKJ2009-2-028);973 Project(No.2010CB834300); Gastric cancer is one of the most common malignancies and a leading cause of cancer mortality worldwide.The pathogenesis mechanisms of gastric cancer are still not fully clear.Inactivation of tumor suppressor genes an...; 关键词：抑癌基因甲基化胃癌肿瘤抑制基因癌组织发病机制表观遗传恶性肿瘤

Aberrant DNA methylation in cervical carcinogenesis被引量：33: 《Chinese Journal of Cancer》2013年第1期42-48,共7页Hui-Juan Yang; Persistent infection wit h high-risk types of human papillomavirus(HPV) is known to cause cervical cancer;however,additional genetic and epigenetic alterations are required for progression from precancerous disease to...; 关键词：DNA甲基化子宫颈癌人类基因组 HPV16 乳头状瘤病毒异常抑癌基因肿瘤抑制基因

Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma被引量：13: 《Chinese Journal of Cancer》2013年第1期3-11,共9页Ji-Sheng Li Jian-Ming Ying Xiu-Wen Wang Zhao-Hui Wang Qian Tao Li-Li Li; supported by NSFC Joint Research Fund for Hong Kong and Macao Young Scholars(No.30928012);National Natural Science Foundation of China(No.81071634,81172582,and 30801344);Shenzhen Science Fund for Distinguished Young Scholars(No.JC201005270328A); Esophageal squamous cell carcinoma(ESCC) is a prevalent and fatal cancer in China and other Asian countries.Epigenetic silencing of key tumor suppressor genes(TSGs) is critical to ESCC initiation and progression.Recen...; 关键词：基因启动子抑癌基因鳞状细胞癌食管癌甲基化肿瘤抑制基因肿瘤标志物表观遗传

Aberrant promoter CpG methylation and its translational applications in breast cancer被引量：7: 《Chinese Journal of Cancer》2013年第1期12-20,共9页Ting-Xiu Xiang Ying Yuan Li-Li Li Zhao-Hui Wang Liang-Ying Dan Yan Chen Guo-Sheng Ren Qian Tao; supported by grants from the National Natural Science Foundation of China(NSFC)(No.#81072148,#81071634and#30928012);Natural Science Foundation of Chongqing(No.2010BB5101);Shenzhen Science Fund for Distinguished Young Scholars(No.JC201005270328A); Breast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations.Recent studies revealed that abnormal gene expression induced by epigenetic changes,including aberrant pr...; 关键词：临床应用乳腺癌甲基化 CPG 异常子区肿瘤抑制基因肿瘤标志物

Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma被引量：7: 《Chinese Journal of Cancer》2012年第5期215-222,共8页Juan Chen Li Fu Li-Yi Zhang Dora L. Kwong Li Yan Xin-Yuan Guan; Nasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China.Deletion of genomic DNA,which occurs during the complex pathogenesis process for NPC,represents a pivotal mechanism in the inactiv...; 关键词：3号染色体抑癌基因鼻咽癌删除全国人民代表大会基因组DNA 肿瘤抑制基因发病机制

Apoptosis and the target genes of microRNA-21被引量：50: 《Chinese Journal of Cancer》2011年第6期371-380,共10页Lindsey E.Becker Buscaglia; supported by the Diabetes and Obesity Center funded by NCRR/NIH(P20RR024489);the Center for Environmental Genomics and Integrated Biology fundedby NIEHS/NIH(P30ES014443);the Scientist Development Grant from American Heart Association(0830288N);a R01 grant from National Institutes of Health(CA138688); MicroRNA-21(miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors.Through functional suppression,miR-21 is implicated in practically every walk of oncogenic life:t...; 关键词：细胞凋亡 microRNA 靶基因程序性细胞死亡肿瘤抑制基因致癌基因 miR 微RNA

Advancement and prospects of tumor gene therapy被引量：10: 《Chinese Journal of Cancer》2011年第3期182-188,共7页Chao Zhang Qing-Tao Wang He Liu Zhen-Zhu Zhang Wen-Lin Huang; supported by Foundation from Knowl edge Innovation Program in CAS (No. KSCX1-YW-R-10);National Natural Science Foundation of China(No. 30973448); Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been deve...; 关键词：肿瘤基因治疗非病毒载体 RNA干扰肿瘤抑制基因反义寡核苷酸抗血管生成树突状细胞肿瘤治疗

p73基因与消化系统肿瘤被引量：3: 《癌症》2004年第1期95-98,共4页信涛方立萍; p73基因是肿瘤抑制基因p53家族的新成员,在编码蛋白的结构、功能等方面两者很相似,但在其它方面有非常显著的差异。许多研究发现p73基因异常与神经母细胞瘤、黑色素瘤、前列腺癌、肺癌有关。近年来还发现p73基因可能参与了一部分消化系...; 关键词：P73基因消化系统肿瘤编码蛋白肿瘤抑制基因

TEY1基因在不同转移潜能肝癌细胞中表达的定量分析: 《癌症》2003年第6期561-565,共5页刘虎叶胜龙李文昌李雁刘银坤钦伦秀邱双健孙瑞霞陈洁汤钊猷; 国家重点基础研究发展规划项目(973项目)(No.G1998051200);国家自然科学基金资助项目(No.30271459); 背景和目的:我们先前的研究提示,肝癌转移抑制基因可能在人染色体8p上。TEY1基因(TEnni-Yokusei1,转移抑制的日文)是最近从人染色体8p发现的前列腺癌转移抑制基因。本研究通过对不同转移潜能肝癌细胞株中TEY1基因的表达水平进行定量分析...; 关键词：TEY1基因肿瘤转移肝癌细胞肿瘤抑制基因荧光定量PCR

肿瘤抑制基因