Background: Mood, cognitive, and behavioural changes have been reported with deep brain stimulation (DBS) in the thalamus, globus pallidus interna, and anterior limb of the internal capsule/nucleus accumbens region. O...
Background: Since the Food and Drug Administration approved DBS, there has been a surge in the number of centers providing the procedure. There is currently no consensus regarding appropriate screening procedures, nec...
A patient with myoclonus- dystonia syndrome was treated by implanting electr odes in the internal segment of the globus pallidus (GPi) and applying deep brai n stimulation. Surgery was done in two sessions. The most a...
In this prospective double blind randomised “ N of 1” study, a patient wit h a severe form of Tourette’ s syndrome was treated with bilateral high frequen cy stimulation of the centromedianparafascicular complex (C...
During the last few years, deep brain stimulation (DBS) of the subthalamic nuc leus (STN) has emerged as a promising therapy, alleviating major motor symptoms of Parkinson’s disease (PD). However, in times of growing...
The aim of this work was to study the role of subthalamo-pallidal synchronisa tion in the pathophysiology of dyskinesias.We recorded local field potentials (L FPs) in a patient with Parkinson’s disease and left surge...
In five patients with medically refractory tardive dystonia, continuous bilateral high- frequency stimulation of the globus pallidus internus was associated with a rapid (within 12 to 72 hours) and substantial (mean 8...
The authors systematically studied the emergence of restless legs syndrome (R LS) after subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson d isease (PD). Postoperatively, 11 of 195 patients with STN ...
The effects of subthalamic nucleus deep brain stimulation were studied in 52 consecutive patients (13 over age 70, 15 under age 60, 24 age 60 to 70). All groups had improvement of motor fluctuations and dyskinesia. Pa...
We provide a detailed case history of the first patient to receive bilateral h ypothalamic stimulation to control severe bilateral chronic intractable cluster headaches initially occurring mostly on the left. These at...