Natural Science Foundation of Jiangsu Province-funded Project:Regulation of Intestinal Epithelial Tight Junction Proteins Through the p38 Mitogen-activated Protein Kinase-Myosin Light Chain kinase Signaling Pathway in Ulcerative Colitis Treatment by Modified Pulsatilla Decoction(No.BK20201179);Jiangsu Health Commission-funded Project:Study on the Prevention of Postoperative Recurrence in Patients with Colorectal Adenoma and High Triglyceride based on the Theory of“Treating the Disease Before It Gets Worse”by Modified Jisheng Wumei Pill(BJ23039);Suzhou Health Commission-funded Project:Study on the Technical Application of Xu Jingfan's“Eliminating Stasis and Protecting Membrane”Method to Regulate Recombinant NLR Family,Pyrin Domain Containing Protein 3 to Repair Esophageal Mucosa in Reflux Esophagitis treatment(SS202080),Suzhou Health Commission-funded Project:(SKY2022015),and Suzhou Health Commission-funded Project:Clinical Diagnostic and Therapeutic Techniques for Reflux Esophagitis Treatment with Graded Step-down Therapy by Combining Traditional Chinese and Western medicine(LCZX201817)。
OBJECTIVE:To investigate the mechanism of the protective effect of modified Pulsatilla decoction(加味白头翁汤,MPD)on the mechanical barrier of the ulcerative colitis(UC)intestinal epithelium in vitro and in vivo.METHO...