N-TERMINAL

作品数：118被引量：321H指数：9
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Threshold-Effect Associations of Serum 25- hydroxyvitamin D on Bone Turnover Markers and GC rs2282679 Variants in Chinese Women of Childbearing Age
《Biomedical and Environmental Sciences》2025年第4期433-446,共14页Xiaoyun Shan Yuting Li Xiayu Zhao Yichun Hu Siran Li Huidi Zhang Yang Cao Rui Wang Lichen Yang 
Objective This study aimed to investigate possible serum 25-hydroxyvitamin D[25(OH)D]cutoffs for the associations between 25(OH)D and Bone turnover markers(BTMs),and how GC gene variation influences such cutoffs in Ch...
关键词：25-hydroxyvitamin D OSTEOCALCIN Procollagen type 1 N-terminal propeptide β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide Gene polymorphism 
GSDMD protects intestinal epithelial cells against bacterial infections through its N-terminal activity affecting intestinal immune homeostasis被引量：1
《Journal of Biomedical Research》2024年第6期585-596,共12页Honghui Li Jie Pu Dongxue Yang Lu Liu Yingchao Hu Shuo Yang Bingwei Wang 
supported by the National Key Research and Development Program of China(Grant No.2022YFA1303900 to S.Y.);the National Natural Science Foundation of China(Grant Nos.32270921 and 82070567 to S.Y.and 82204354 to Y.H.);the Open Project of the State Key Laboratory of Reproductive Medicine of Nanjing Medical University(Grant No.SKLRM-2021B3 to S.Y.);the Talent Cultivation Project of"Organized Scientific Research"of Nanjing Medical University(Grant No.NJMURC20220014 to S.Y.);the Natural Science Foundation of Jiangsu Province(Grant No.BK20221352 to B.W.);the Jiangsu Provincial Outstanding Postdoctoral Program(Grant No.2022ZB419 to Y.H.);the Postdoctoral Research Funding Project of Gusu School(Grant No.GSBSHKY202104 to Y.H.);the China Postdoctoral Science Foundation(Grant No.2023T160329 to Y.H.).
The intestinal mucosal barrier serves as a vital guardian of the gut health,maintaining a delicate equilibrium between gut microbiota and host immune homeostasis.Gasdermin D(GSDMD),a key executioner of pyroptosis down...
关键词：GSDMD PYROPTOSIS Citrobacter rodentium infection intestinal mucosal barrier 
Identification of a novel germline APC N-terminal pathogenic variant associated with attenuated familial adenomatous polyposis
《Genes & Diseases》2024年第6期12-15,共4页Giovanna Forte Valentina Grossi Filomena Cariola Antonia Lucia Buonadonna Paola Sanese Katia De Marco Candida Fasano Martina Lepore Signorile Vittoria Disciglio Cristiano Simone 
Adenomatouspolyposis coli(APC)is akey tumor suppressor gene playing a central role in the Wnt signaling pathway throughβ-catenin down-regulation.1 APC germline pathogenic variants are associated with familial adenoma...
关键词：POLYPOSIS adenomatous FAMILIAL 
The impact of N-terminal modification of PAA with different chain lengths on the structure,thermal stability and pH sensitivity of succinylated collagen
《Collagen and Leather》2024年第2期93-103,共11页Juntao Zhang Yang Liu Haofei Xu Peishan Sui Tianyi Liu Mingming Zheng Evgeny AShirshin Benmei Wei Chengzhi Xu Haibo Wang 
supported by the National Natural Science Foundation of China(Nos.22378320,22178277,21706201);Knowledge Innovation Program of Wuhan-Basi Research,China(No.2023020201010148);Appli cation Foundation Frontier Project of Wuhan Science and Technology Bureau,China(No.2019020701011478).
The limitations of native collagen,such as thermal stability and solubility in physiological environments,can be improved by applying bioconjugation and synthetic chemistry techniques.However,the exquisite control of ...
关键词：Succinylated collagen-PAA bioconjugate Polymer chain length Thermal stability 
Prognostic value of N-terminal pro B-type natriuretic peptide and troponin Ⅰ in children with dengue shock syndrome
《Asian Pacific Journal of Tropical Medicine》2024年第4期166-172,共7页Truyen Phuoc Le Phung Nguyen The Nguyen 
Objective:To investigate the contribution of N-terminal pro B-type natriuretic peptide(NT-pro BNP)and troponin Ⅰ to mortality in children with dengue shock syndrome.Methods:A longitudinal study was conducted on child...
关键词：Dengue shock syndrome Cardiac enzyme NT-pro BNP TroponinⅠ 
N-terminal truncated phospholipase A1 accessory protein PlaS from Serratia marcescens alleviates inhibitory on host cell growth and enhances PlaA1 enzymatic activity
《Bioresources and Bioprocessing》2024年第1期823-834,共12页Mengkai Hu Jun Liu Yufei Gan Hao Zhu Rumeng Han Kun Liu Yan Liu Ming Zhao Xiangfei Li Zhenglian Xue 
financially supported by National Natural Science Foundations of China(No.31471615);Scientific Research Start-up Fund for Introduced Talents of Anhui Polytechnic University(2022YOO068);Natural Science Research Project of Colleges and Universities in Anhui Province(Grant 2022AH050971).
Phospholipase A1(PLA1)is a kind of specific phospholipid hydrolase widely used in food,medical,textile.However,limitations in its expression and enzymatic activity have prompted the investigation of the phospholipase-...
关键词：Phospholipase A1 PLAS N-terminal truncation Protein-protein interaction Enzymatic activity 
Crude enzyme immobilization‑based cell‑free system for efficient N‑acetylneuraminic acid biosynthesis aided by N‑terminal coding sequence screening
《Systems Microbiology and Biomanufacturing》2023年第3期479-488,共10页Peng Wen Xueqin Lv Long Liu Jianghua Li Guocheng Du Yanfeng Liu 
the National Key Research and Development Program of China(2020YFA0908300);National Science Fund for Excellent Young Scholars(32222069);National Natural Science Foundation of China(32172349);Natural Science Foundation of Jiangsu Province(BK20200085);Key Research and Development Program of Jiangsu Province(BE2019628).
N-acetylneuraminic acid(NeuAc)is an important nutrient that plays a key role in brain development in infants NeuAc is mainly produced by extraction from natural resources such as edible birds’s nests,crucian eggs,cav...
关键词：N-acetylneuraminic acid IMMOBILIZATION Cell-free system N-terminal coding sequences 
Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway被引量：3
《World Journal of Gastroenterology》2023年第22期3422-3439,共18页Jun-Hua Fan Na Luo Geng-Feng Liu Xiao-Fang Xu Shi-Quan Li Xiao-Ping Lv 
a Grant-in-Aid for Scientific Research from National Natural Science Foundation of China,No. 81860120 and 81860104;Guangxi Natural Science Foundation,No. 2017GXNSFBA198134, 2017GXNSFAA198299 and 2015GXNSFCA139024
BACKGROUND Hepatic fibrosis is a common pathological process of chronic liver diseases with various causes,which can progress to cirrhosis.AIM To evaluate the effect and mechanism of action annexin(Anx)A1 in liver fib...
关键词：Annexin A1 Active N-terminal peptide of annexin A1 MACROPHAGE Hepatic stellate cell WNT/Β-CATENIN Liver fibro 
Translation rate underpins specific targeting of N-terminal transmembrane proteins to mitochondria
《Journal of Integrative Plant Biology》2023年第6期1505-1520,共16页Junho Lee Byeongho Moon Dong Wook Lee Inhwan Hwang 
supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.2022R1A2C1091844)。
Protein biogenesis is a complex process,and complexity is greatly increased in eukaryotic cells through specific targeting of proteins to different organelles.To direct targeting,organellar proteins carry an organelle...
关键词：arginine-rich region ER targeting mitochondria targeting organelle targeting TMD translational slowdown transmembrane domain 
Supramolecular approaches for insulin stabilization without prolonged duration of action
《Acta Pharmaceutica Sinica B》2023年第5期2281-2290,共10页Rolande Meudom Yanxian Zhang Michael A.VandenBerg Lei Zou Yi Wolf Zhang Matthew J.Webber Danny Hung-Chieh Chou 
NIDDK(DK120430,DK121336,USA)to Danny Hung-Chieh Chou;JDRF(5-CDA-2020-947-A-N,USA)to Matthew J.Webber。
Aggregation represents a significant challenge for the long-term formulation stability of insulin therapeutics.The supramolecular PEGylation of insulin with conjugates of cucurbit[7]uril and polyethylene glycol(CB[7]-...
关键词：Diabetes mellitus Insulin aggregation Supramolecular PEGylation Selective N-Terminal modification N-terminal acid-modified insulin Subcutaneous depot HYPOGLYCEMIA Subcutaneous administration 
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