OLIGONUCLEOTIDES

作品数：75被引量：205H指数：6
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Metal-Triggered DNA Folding by Different Mechanisms
《Chinese Journal of Chemical Physics》2015年第5期-,共9页Wei Deng Bin Zheng Wei Ding Hong Zhu Hao-jun Liang 
the National Natural Science Foundation of China，the National Basic Research Program of China，the Foundation for Scholar of Hefei Normal University，the Foundations of Educational Committee of Anhui Province
关键词：Metal-mediated base pairs Hg2+ and Ag+ T-C-rich oligonucleotides Folding mechanisms T-Ag-C base pair 
Supramolecular self-assembly for delivery of oligonucleotides and its phototriggered unpacking in living cells
《Journal of Chinese Pharmaceutical Sciences》2014年第7期454-462,共9页王鹏 纪玉卓 王志轩 汤新景 
National Natural Science Foundation of China(Grant No.21372018);the National Basic Research Program of China(973 Program,Grant No.2013CB933800);Program for New Century Excellent Talents in University(Grant No.NCET-10-0203);the State Key Laboratory of Pharmaceutical Biotechnology(Grant No.KF-GN-201305)
Two photolabile amphiphilic supramolecules were designed and synthesized with mono-dendrite and tri-dendrite, which can reversibly self-assemble to spheroid and wedge-shaped nanoparticles. With multiple branches of te...
关键词：Photo-activation SUPRAMOLECULE SELF-ASSEMBLY Oligonucleotide delivery Nucleic acid unpacking 
Synthesis,physicochemical and biological properties of oligonucleotides incorporated with amino-isonucleosides
《中国科学：化学》2012年第2期213-214,共2页WANG Fang CHEN Yue HUANG Ye JIN Hong-Wei ZHANG Liang-Ren YANG Zhen-Jun ZHANG Li-He 
Antisense oligonucleotides(ASONs) and siRNAs have been applied extensively for the regulation of cellular and viral gene expression,and RNAi is currently one of the most promising new approaches for anti-tumor and ant...
关键词：反义寡核苷酸 异核苷 氨基酸 生物学特性 注册 合成 SIRNAS 抗病毒治疗 
Synthesis,physicochemical and biological properties of oligonucleotides incorporated with amino-isonucleosides被引量：3
《Science China Chemistry》2012年第1期70-79,共10页WANG Fang CHEN Yue HUANG Ye JIN Hong-Wei ZHANG Liang-Ren YANG Zhen-Jun ZHANG Li-He 
supported by the National Natural Science Foundation of China(20932001);the Ministry of Science and Technology of China (2006AA02Z144,2009ZX09503)
Antisense oligonucleotides(ASONs) and siRNAs have been applied extensively for the regulation of cellular and viral gene expression,and RNAi is currently one of the most promising new approaches for anti-tumor and ant...
关键词：amino-isonucleoside antisense oligonucleotide SIRNA 
Label-free detection of hybridization of oligonucleotides by oblique-incidence reflectivity difference method被引量：8
《Science China(Physics,Mechanics & Astronomy)》2010年第8期1434-1437,共4页YUAN Kun WANG Xu LU Heng WEN Juan LU HuiBin ZHOU YueLiang JIN Kui-Juan YANG GuoZhen LI Wei RUAN KangCheng 
supported by the National Basic Research Program of China (Grant No. 2007CB935700)
The microarrays of 20-base oligonucleotide with different concentrations are detected before and after hybridization by the oblique-incidence reflectivity difference (OI-RD) method. The experimental results prove that...
关键词：oblique-incidence reflectivity difference microarray detection label-free detection oligonucleotides microarray 
Fluorescence quenching of TMR by guanosine in oligonucleotides被引量：1
《Science China Chemistry》2009年第10期1653-1659,共7页QU Peng CHEN XuDong ZHOU XiaoXue LI Xun ZHAO XinSheng 
Supported by the National Natural Science Foundation of China (Grant Nos. 20673002, 20733001);the 973 Project (2006CB910304)
Nucleotide-specific fluorescence quenching in fluorescently labeled DNA has many applications in biotechnology. We have studied the inter-and intra-molecular quenching of tetramethylrhodamine (TMR) by nucleotides to b...
关键词：TMR GUANOSINE FLUORESCENCE OLIGONUCLEOTIDES G-quenching PET FCS 
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