OLIGONUCLEOTIDES

作品数：75被引量：205H指数：6
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Synthesis,physicochemical and biological properties of oligonucleotides incorporated with amino-isonucleosides被引量：3
《Science China Chemistry》2012年第1期70-79,共10页WANG Fang CHEN Yue HUANG Ye JIN Hong-Wei ZHANG Liang-Ren YANG Zhen-Jun ZHANG Li-He 
supported by the National Natural Science Foundation of China(20932001);the Ministry of Science and Technology of China (2006AA02Z144,2009ZX09503)
Antisense oligonucleotides(ASONs) and siRNAs have been applied extensively for the regulation of cellular and viral gene expression,and RNAi is currently one of the most promising new approaches for anti-tumor and ant...
关键词：amino-isonucleoside antisense oligonucleotide SIRNA 
A new quantitative structure-retention relationship model for predicting chromatographic retention time of oligonucleotides被引量：2
《Science China Chemistry》2011年第7期1064-1071,共8页ZHAO Wei LIANG GuiZhao CHEN YuZhen YANG Li 
supported by the National Natural Science Foundation of China (10901169);National 111 Programme of Introducing Talents of Discipline to Universities (0507111106);Innovation Ability Training Foundation of Chongqing University (CDCX008);Innovative Group Program for Graduates of Chongqing University,Science;Innovation Fund (200711C1A0010260)
An integrated approach is proposed to predict the chromatographic retention time of oligonucleotides based on quantitative structure-retention relationships （QSRR） models. First, the primary base sequences of oligon...
关键词：OLIGONUCLEOTIDE quantitative structure-retention relationship scores of generalized base properties auto cross covariance genetic algorithm support vector machine 
Interaction of bis-aryl functionalized molecules with nucleosides and nucleic acids被引量：1
《Science China Chemistry》2010年第1期103-112,共10页HUANG Yu1,LIU JunLiang1,ZHANG Ji1,LIU Qiang1,HOU JiTing1,ZHANG Yu1,ZHANG DaWei2,LU QiaoSen1,CHEN ShanYong1,LIN HongHui2 & YU XiaoQi1 1 Key Laboratory of Green Chemistry and Technology,Ministry of Education College of Chemistry,Sichuan University,Chengdu 610064,China 2 Key Laboratory of Bio-resources and Eco-environment,Ministry of Education College of Life Sciences,Sichuan University,Chengdu 610064,China. 
supported by the National Natural Science Foundation of China (Grant Nos.20725206 and 20732004);Specialized Research Fund for the Doctoral Program of Higher Education;Scientific Fund of Sichuan Province for Outstanding Young Scientists
A series of novel molecules with a cyclen(1,4,7,10-tetraazacyclododecane) moiety appended on and bearing different aromatic fragments in the structures were synthesized and characterized.The binding activities of thes...
关键词：stacking and HYDROPHOBIC interactions DNA binding AROMATIC compounds NUCLEOSIDES OLIGONUCLEOTIDES 
Fluorescence quenching of TMR by guanosine in oligonucleotides被引量：1
《Science China Chemistry》2009年第10期1653-1659,共7页QU Peng CHEN XuDong ZHOU XiaoXue LI Xun ZHAO XinSheng 
Supported by the National Natural Science Foundation of China (Grant Nos. 20673002, 20733001);the 973 Project (2006CB910304)
Nucleotide-specific fluorescence quenching in fluorescently labeled DNA has many applications in biotechnology. We have studied the inter-and intra-molecular quenching of tetramethylrhodamine (TMR) by nucleotides to b...
关键词：TMR GUANOSINE FLUORESCENCE OLIGONUCLEOTIDES G-quenching PET FCS 
Computational analysis of triplex formation of oligonucleotides:protonated and 5-methylated py-pu-py motif被引量：2
《Science China Chemistry》1997年第2期113-121,共9页白春礼 王琛 汪新文 
Work supported by the Chinese Academy of Sciences
A triple helix composed of three dodecanucleotides,5'-d(TC)6,5-(AG)6 and 3'-d(TC)6 with each containing a methylcytosme or a protonated-cylosine,was examined in terms of various interactions Computational malvsis of t...
关键词：TRIPLEX DNA computational analysis stability SCREENING effect 
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