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Acellular scaffold‑based approach for in situ genetic engineering of host T‑cells in solid tumor immunotherapy: 《Military Medical Research》2025年第1期16-35,共20页Hiren Y.Dandia Mamatha M.Pillai Deepak Sharma Meghna Suvarna Neha Dalal Ayush Madhok Arvind Ingle Shubhada V.Chiplunkar Sanjeev Galande Prakriti Tayalia; Department of Biotechnology(DBT,Govt of India)(BT/PR31315/MED/32/667/2019);DBT along with Wadhwani Research Center for Bioengineering,IIT Bombay(BT/INF/22/SP23026/2017);Department of Biotechnology(DBT,Govt of India)(BT/INF/22/SP17358/2016).; Background:Targeted T-cell therapy has emerged as a promising strategy for the treatment of hematological malignancies.However,its application to solid tumors presents significant challenges due to the limited accessi...; 关键词：Polyethylene glycol diacrylate POLY-L-LYSINE LENTIVIRUSES T-cell therapy B16F10-OVA melanoma

In vivo fluorescence flow cytometry reveals that the nanoparticle tumor vaccine OVA@HA-PEI effectively clears circulating tumor cells: 《Journal of Innovative Optical Health Sciences》2024年第6期107-123,共17页Wei Jin Yuting Fu Sisi Ge Han Sun Kai Pang Xunbin Wei; supported by the National Key Research and Development Program of China,Grant Number:2021YFF0502900,2019YFC1604604;National Natural Science Foundation of China,Grant Number:62075013,62027824.; Tumor vaccine therapy offers significant advantages over conventional treatments,including reduced toxic side effects.However,it currently functions primarily as an adjuvant treatment modality in clinical oncology due...; 关键词：Tumor vaccines circulating tumor cells in vivo fluorescence flow cytometry.

Untargeted serum metabonomic reveals alleviated ovalbumin-induced asthma by Baijin Pingchuan(白金平喘)through primary bile acid biosynthesis: 《Journal of Traditional Chinese Medicine》2024年第6期1187-1193,共7页DING Lizhong ZHANG Qiang SUN Yingying KONG Yibu SONG Yongfu WANG Yongji; Science and Technology Development Plan Project of Jilin Provincial:Research on the Development of Baijin Pingchuan Granules as an In-hospital Preparation for the Treatment of Pediatric Asthma (Heat-type Asthma)(No. 20200404043YY);Traditional Chinese Medicine Science and Technology Project of Jilin Provincial:Exploring the Mechanism of Baijin Pingchuan Granules in Alleviating Airway Inflammation in Asthma based on the “Three-Stage Differentiation and Treatment” Theory of National Medical Masters (2020090)。; OBJECTIVE: To investigate the effect of baijinpingchuan(白金平喘, BJPC) on the asthma rat model and identify differential metabolites and disturbed metabolic pathways. METHODS: The rats were categorized into six group...; 关键词：ASTHMA OVALBUMIN untargeted serum metabonomic Baijin Pingchuan

太子参多糖对OVA免疫小鼠肠道免疫应答能力的影响: 《福建农林大学学报（自然科学版）》2024年第6期772-778,共7页赵佳梅杜蓥蓥曾丽曾靖棋周梦圆陈颖清秦凤远李健潘慧青马玉芳; 福建省重大专题项目(2021NZ02908);福建省科技厅区域发展项目(2022N3017)。; 【目的】研究太子参多糖(PHPS)对卵清白蛋白(OVA)免疫小鼠肠道免疫应答的影响,为了解PHPS能否增强小鼠机体的免疫应答能力提供依据。【方法】将72只健康清洁级(SPF)雌性ICR小鼠随机分成空白对照组(CK组)、OVA免疫对照组(OVA组)、铝佐剂...; 关键词：太子参多糖卵清白蛋白肠道免疫应答小鼠

不同砧穗组合苹果果实成熟期香气物质分析: 《中国南方果树》2024年第5期178-187,共10页贾永华马军李晓龙许泽华李百云; 国家苹果产业技术体系(CARS-27)资助。; 为了探究新疆野苹果+M26+礼泉短富、新疆野苹果+M26+岩富10、新疆野苹果+M26+玉华早富、八棱海棠+SH1+长富2号、八棱海棠+长富2号、八棱海棠+礼泉短富等6个宁夏主栽砧穗组合苹果果实风味品质差异,在银川市西夏区芦花乡试验基地8年生树...; 关键词：苹果砧穗组合挥发性化合物 OVA PCA OPLS-DA

Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice: 《Food Science and Human Wellness》2024年第4期2346-2352,共7页Jialu Shi Yan Xu Cheng Liu Shizhi Wang Jin Wang Vijaya Raghavan; the financial supporting by the National Key Research and Development Program of China(2022YFF1102400);National Natural Science Foundation of China(32102093);the Natural Science Foundation of Jiangsu Province(BK20210226)。; Food allergy is a significant public health concern globally.Certain probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and patients.However,the effects of Bi...; 关键词：Food allergy Bifidobacterium lactis Probio-M8 T cell immune response Gut microbiota

基于酵母β-葡聚糖载体的口服OVA疫苗(WGP-OVA疫苗)诱导体液免疫及抗原特异性T细胞免疫反应: 《中国免疫学杂志》2024年第8期1579-1583,1589,共6页白煜戚春建夏蕾何树燕何流漾; 国家自然科学基金(32270954);常州市科技计划项目(CJ20220082);江阴市卫健委面上项目(S202101)。; 目的:探讨口服WGP-OVA疫苗对C57BL/6小鼠体液免疫及抗原特异性T细胞免疫的诱导作用。方法:分别连续给予C57BL/6小鼠口服PBS、WGP及WGP-OVA 17 d后,使用LEGENDplexTM多因子流式检测试剂盒检测给药后小鼠血清中IgG1、IgG2a、IgG3及IgM的含...; 关键词：全β-葡聚糖颗粒鸡卵清蛋白口服疫苗免疫球蛋白抗原特异性T细胞

首列氢能源智能城际动车组问世: 《山东交通科技》2024年第4期22-22,共1页; 氢能源,作为21世纪最具潜力的清洁能源之一,正逐渐成为推动绿色交通发展的重要力量。2024年9月24日,我国在氢能轨道交通技术领域取得了重大突破,由中车青岛四方股份公司自主研制的首列氢能源智能城际动车组CINOVA H2在柏林国际轨道交通...; 关键词：氢燃料电池氢能源电化学反应轨道交通技术绿色交通清洁能源自主研制 OVA

Oral administration of Bacillus coagulans TQ-35 alleviates allergic responses in OVA-sensitive BALB/c mice: 《Food Science and Human Wellness》2024年第3期1246-1257,共12页Yifan Wang Shanjun Chen Chong Wang Yi Zhang Hongliang Zeng Linglin Fu Yanbo Wang; financially supported by the National Key R&D Program of China (2019YFC1605003);the Zhejiang Provincial Natural Science Foundation of China (LGN21C200013)。; Bacillus coagulans has been extensively studied so far,but there has been a lack of research on its usage in allergy.In this study,we designed to assess the effect of different concentrations of B.coagulans on food al...; 关键词：Bacillus coagulans TQ-35 Food allergy Ovalbumin(OVA) Gut microbiota

自组装纳米颗粒肿瘤疫苗OVA257-264-mi3的构建及其保护效果评价: 《陆军军医大学学报》2024年第12期1361-1368,共8页陈源高晨李宇航崔致远程新张怡于博顾江杨宪; 国家重点研发计划(2021YFC2301405)。; 目的构建SpyCatcher-mi3纳米颗粒疫苗递送载体,评价其在增强卵清蛋白CD8+T细胞表位肽OVA 257-264免疫原性和在小鼠荷瘤模型中免疫保护效果。方法SpyCatcher-mi3蛋白由大肠杆菌表达,依次经亲和层析、阴离子交换层析纯化得到;合成OVA 257-...; 关键词：SpyCatcher-mi3 OVA 257-264 纳米颗粒疫苗保护效果评价

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