supported by grants from the National Natural Science Foundation of China (31630079,31672531,31572526,and 31802164);the National Key R&D Program of China (2016YFD0500206,2015BAD11B02);the Strategic Priority Research Program of Chinese Academy of Sciences (XDB29010000);the National Science and Technology Major Project (2018ZX10101004);the Emergency Technology Research Issue on Prevention and Control for Human Infection with A (H7N9) Avian Influenza Virus (10600100000015001206);Wenjun Liu is the principal investigator of the Innovative Research Group of National Natural Science Foundation of China (Grant No.81621091)
Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin–proteasome-mediated deg...