supported by a grant from the Ministry of Health (Research for the Strategic Program 2007)
Parkinson's disease has a negative impact on health-related quality of life in Parkinson's disease patients. Depression, cognitive impairment, coping strategies, dyskinesia, gait disorders and complications of dopam...
the grants from Shanghai Educational Committee, No. 03BZ03;Department of Education for Doctor Foundation, No. 20040266014;Shanghai Jiao Tong University Medical School for Doctor Foundation, No. BXJ0304
At present, pathogenesis and mechanism of Parkinson disease (PD) are still unclear. Animal models of PD are essential tools in studies on etiology and therapy and should mimic the chronic pathological process, histo...
the Natural Science Foundation of Jiangsu Department of Education, No. 02KJB310009
BACKGROUND: Substantia nigra is deep in position and limited in range, the glial cell line-derived neurotrophic factor (GDNF) injection directly into substantia nigra has relatively greater damages with higher diff...
OBJECTIVE: To review the recent progresses on the studies of α -synuclein in the pathogenesis of Parkinson disease (PD) and look into the perspective of α -synuclein as a new therapy target. DATA SOURCES: To sea...
BACKGROUND: Parkinson disease (PD) results from the reduce of neurotransmitter dopamine that transmits intracellular information in brain caused by some reasons, then leads to the dynamic disequilibrium with anothe...
BACKGROUND: Literatures have reported that the density changes of dopamine transporter is negatively correlated with the severity degree and grading of disease condition of Parkinson disease (PD). However, the dist...
BACKGROUND: With the development of neuroelectrophysiology, it had been identified that all kinds of evoked potentials might reflect the functional status of corresponding pathway. Evoked potentials recruited in the ...
Foundation for the Returned Overseas Chinese Scholars of Guangxi Zhuang Autonomous Region, No. 0448017
BACKGROUND: Previous researches found that animal models with Parkinson disease (PD) could be established by injecting 6-hydroxydopamine (6-OHDA) into medial forebrain bundle (MFB), substantia nigra compacta (...
Scientific and Technological Project of State Ministry of Education, No. 204055; the Natural Science Foundation of Educational Bureau of Jiangsu Province, No. 02KJB310009
BACKGROUND: Previous researches suggested that expression level of calbindin D28K mRNA decreased in substantia nigra (SN) of model rats with Parkinson disease (PD), and this might be related to the decrease of an...