PARKINSON_DISEASE

作品数：125被引量：198H指数：7
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相关机构：首都医科大学附属北京天坛医院福建医科大学环境与疾病相关基因教育部重点实验室西安交通大学更多>>
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Protective effect of resveratrol on rat cardiomyocyte H9C2 cells injured by hypoxia/reoxygenation by regulating mitochondrial autophagy via PTEN-induced putative kinase protein 1/Parkinson disease protein 2 signaling pathway被引量：3
《Journal of Traditional Chinese Medicine》2022年第2期176-186,共11页ZHAO Lixia SUN Wei BAI Decheng 
Supported by the Open Fund of Key Laboratory of Dunhuang Medicine,Ministry of Education(DHYX20-09);the Youth Research Foundation of the Gansu University of Chinese Medicine(No.ZQ2017-14)。
OBJECTIVE:To investigate the protective effect of resveratrol on cardiomyocytes after hypoxia/reoxygenation intervention based on PTEN-induced putative kinase protein 1/Parkinson disease protein 2(PINK1/PARKIN)signali...
关键词：RESVERATROL MYOCYTES cardiac hypoxia PTEN phosphohydrolase Parkinson disease associated proteins mitochondrial autophagy 
A small-molecule activator of ULK1 that induces cytoprotective autophagy for Parkinson disease treatment被引量：1
《中国药理学与毒理学杂志》2017年第10期981-981,共1页Lan ZHANG Da-hong YAO Guan WANG 
supported by National Natural Science Foundation of China(81602953);China Postdoctoral Special Science Foundation(2017T100706);China Postdoctoral Science Foundation(2016M590893)
OBJECTIVE To discover a small-molecule activator of ULK1 for Parkinson disease treatment and exploreits potential mechanisms.METHODS Candidate ULK1 activator was found by using structure-based design and high-through ...
关键词：AUTOPHAGY Parkinson disease UNC-51-like kinase 1 ULK1 activator ULK complex 
Loss of microglial autophagy causes Parkinson disease-like symptom in mice
《中国药理学与毒理学杂志》2017年第5期462-462,共1页CHENG Jin-bo LIAO Ya-jin LI Xiao-heng DONG Yuan TANG Bai-sha 袁增强 
Microglia activation induced neuroinflammation closely relates with the development of Parkinson disease. Autophagy regulates many biological processes,but the role in microglial activation and the development of Park...
关键词：MICROGLIA Parkinson disease AUTOPHAGY 
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