PARKINSON_DISEASE

作品数：125被引量：198H指数：7
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相关机构：首都医科大学附属北京天坛医院福建医科大学环境与疾病相关基因教育部重点实验室西安交通大学更多>>
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Current Nondopaminergic Therapeutic Options for Motor Symptoms of Parkinson＇s Disease被引量：4
《Chinese Medical Journal》2017年第15期1856-1866,共11页Juan-Juan Du Sheng-Di Chen 
This work was supported by grants from the National Natural Science Foundation of China （No. 81371407 and No. 81430022）.
Objective：The aim of this study was to summarize recent studies on nondopaminergic options for the treatment of motor symptoms in Parkinson＇s disease （PD）.Data Sources：Papers in English published in PubMed,Cochra...
关键词：DYSKINESIAS Motor Fluctuations Nondopaminergic Options Parkinson Disease 
Long-term Levodopa Treatment Accelerates the Circadian Rhythm Dysfunction in a 6-hydroxydopamine Rat Model of Parkinson＇s Disease被引量：3
《Chinese Medical Journal》2017年第9期1085-1092,共8页Si-Yue Li Ya-Li Wang Wen-Wen Liu Dong-Jun Lyu Fen Wang Cheng-Jie Mao Ya-Ping Yang U-Fang Hu Chun-Feng Liu 
This work was supported by grants from the National Natural Science Foundation of China （No. 91649114）,Jiangsu Provincial Special Program of Medical Science （No. BL2014042）, the Plans for Graduate Research and Innovation in Colleges and Universities of Jiangsu Province （No. KYZZ15_0334）, and Suzhou Clinical Research Center of Neurological Disease （No. Szzx201503）. This was also partly supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions and Jiangsu Provincial Medical Key Discipline Project.
Background： Parkinson＇s disease （PD） patients with long-term levodopa （L-DOPA） treatment are suffering from severe circadian dysfunction. However, it is hard to distinguish that the circadian disturbance in pati...
关键词：Circadian Rhythm LEVODOPA Oxidopamine Parkinson Disease 
Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells被引量：3
《Acta Pharmacologica Sinica》2015年第11期1300-1307,共8页Xiao-ou HOU Jian-min SI Hai-gang REN Dong CHEN Hong-feng WANG Zheng YING Qing-song HU Feng GAO Guang-hui WANG 
Aim： Parkin has been shown to exert protective effects against 6-hydroxydopamine （6-OHDA）-induced neurotoxicity in different models of Parkinson disease. In the present study we investigated the molecular mechanism...
关键词：Parkinson disease PARKIN P62 ERK1/2 6-OHDA PC12 cells 
Long-term Efficacy of Subthalamic Nucleus Deep Brain Stimulation in Parkinson＇s Disease： A 5-year Follow-up Study in China被引量：13
《Chinese Medical Journal》2015年第18期2433-2438,共6页Lu-Lu Jiang Jin-Long Liu Xiao-Li Fu Wen-Biao Xian Jing Gu Yan-Mei Liu Jing Ye Jie Chen Hao Qian Shao-Hua Xu Zhong Pei Ling Chen 
Background： Subthalarnic nucleus deep brain stimulation （STN DBS） is effective against advanced Parkinson＇s disease （PD）, allowing dramatic improvement of Parkinsonism, in addition to a significant reduction in ...
关键词：Deep Brain Stimulation Follow-Up Studies Parkinson Disease Subthalamic Nucleus Treatment Outcome 
Apathy in Parkinson disease
《Frontiers in Biology》2014年第4期324-331,共8页Marina NODEL Nikolay YAKHNO Anastasia MEDVEDEVA Michail KULIKOV 
Apathy is one of the least investigated symptom of Parkinson disease （PD）. In the article there are data of frequency, diagnostic features, pathophysiology and treatment of apathy in PD. The aim of the investigation...
关键词：Parkinson disease neuropsychiatric symptoms APATHY HETEROGENEITY 
Lack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson＇s disease in the northern Han Chinese population被引量：2
《Chinese Medical Journal》2012年第4期588-592,共5页Zhu Lan-hui Luo Xiao-guang Zhou Yi-shu Li Feng-rui Yang Yi-chun Ren Yan Pang Hao 
This work was supported by a grant from the National Natural Science Foundation of China （No.30771833）.
Background Parkinson＇s disease （PD） is an autosomally inherited neurodegenerative disease in elderly people.The etiology of PD has long been thought to be associated with both genetic and environmental factors.To e...
关键词：Parkinson disease PARK9 PARK15 BST1 genetic association studies 
Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo被引量：6
《Acta Pharmacologica Sinica》2010年第8期900-906,共7页Zhen-tao ZHANG Xue-bing CAO Nian XlONG Hong-cai WANG Jin-sha HUANG Sheng-gang SUN Tao WANG 
Acknowledgements This work was supported by grants from National Natural Science Foundation of China （No 30570627 and No 30870866）.
Aim： To investigate the neuroprotective effects of morin on 1-methyt-4-phenylpyridinium ion （MPP＋）-induced apoptosis in neuronal dif- ferentiated PC12 cells as well as in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyri...
关键词：MORIN apoptosis PC12 cells MPTP Parkinson disease DOPAMINE 
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