PHOSPHATASE

作品数：260被引量：894H指数：14
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相关机构：中国科学院遗传与发育生物学研究所山东大学湖北中医药大学安徽中医学院第一附属医院更多>>
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WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation被引量：10
《Neuroscience Bulletin》2017年第3期292-298,共7页Dahu Li Lijun Zhang Xin Huang Lili Liu Yunling He Lun Xu Yiyao Zhang Tong Zhao Liying Wu Yongqi Zhao Kuiwu Wu Yan Wu Ming Fan Lingling Zhu 
supported by the National Natural Science Foundation of China(31401000 and 81430044);the Youth Medicine Program of the People’s Liberation Army of China(13QNP148);the National Basic Research Development Program(973 Program)of China(2012CB518200);the Integrated Drug Discovery Technology Platform of National Science and Technology Major Projects for‘‘Major New Drugs Innovation and Development’’,China(2012ZX09J12201-005)
The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unkno...
关键词：Hypobaric hypoxia Inflammation Brain injury WIP1 phosphatase Lipopolysaccharide 
Phosphatase and Tensin Homologue Genetic Polymorphisms and their Interactions with Viral Mutations on the Risk of Hepatocellular Carcinoma被引量：5
《Chinese Medical Journal》2015年第8期1005-1013,共9页Yan Du Yu-Wei Zhang Rui Pu Xue Han Jian-Ping Hu Hong-Wei Zhang Hong-Yang Wang Guang-Wen Cao 
the National Key Basic Research Program (973 Project)，the National Natural Science Foundation of China，the Science and Technology Commission of Shanghai Municipality No.12ZR1453600)
Background： Chronic hepatitis B virus （HBV） infection is the major cause of hepatocellular carcinoma （HCC）. Some HBV mutants and dysregulation of phosphatase and tensin homolog （PTEN） may promote the developmen...
关键词：Hepatitis B Virus Hepatocellular Carcinoma Polymorphism Phosphatase and Tensin Homolog Viral Mt  tation 
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes被引量：2
《Cell Research》2014年第9期1067-1090,共24页Hong-Mei Wang Yun-Fei Xu Shang-Lei Ning Du-Xiao Yang Yi Li Yu-Jie Du Fan Yang Ya Zhang Nan Liang Wei Yao Ling-Li Zhang Li-Chuan Gu Cheng-Jiang Gao Qi Pang Yu-Xin Chen3 Kun-Hong Xiao Rong Ma Xiao Yu Jin-Peng Sun 
Acknowledgments This work was supported by the National Key Basic Research Program of China （2013CB967700 to X Yu; 2012CB910402 to JP Sun）, the National Natural Science Foundation of China （31000362 to X Yu, 31100580 and 31271505 to JP Sun, and 81171062 to Q Pang）, and the Shandong Natural Science Fund for Distinguished Young Scholars （JQ201320 to X Yu）, the Fundamental Research Funds of Shandong University （2014JC029 to X Yu）, the State Key Laboratory of Cell Biology and the Program for Changjiang Scholars and Innovative Research Team in University （IRT 13028）.
The tyrosine phosphorylation barcode encoded in C-terminus of HER2 and its ubiquitination regulate diverse HER2 functions. PTPN18 was reported as a HER2 phosphatase; however, the exact mechanism by which it defines HE...
关键词：PHOSPHATASE receptor UBIQUITINATION HER2 PTPN18 EGFR 
Environmental factors in the development and progression of late-onset Alzheimer's disease被引量：6
《Neuroscience Bulletin》2014年第2期253-270,共18页Moses N. Wainaina Zhichun Chen Chunjiu Zhong 
supported by National Basic Research Development Program(973 Program)of China(2011CBA00400);the National Natural Science Foundation of China(91332201);the Natural Science Foundation of Shanghai Municipality,China(13JC1401500);the Fund for Medical Emerging Cutting-edge Technology of Shanghai Municipality,China(SHDC12012114)
Late-onset Alzheimer＇s disease （LOAD） is an age-related neurodegenerative disorder characterized by gradual loss of synapses and neurons, but its pathogenesis remains to be clarified. Neurons live in an environment...
关键词：Alzheimer＇s disease environmental factors corticotrophin-releasing factor CEREBROVASCULAR metatoxicity GLIA astrocyte microglia AI3 kinase PHOSPHATASE tau HYPERPHOSPHORYLATION epigenetic modificationDNA methylation histone acetylation 
Combined Effects of Cadmium and Butachlor on Microbial Activities and Community DNA in a Paddy Soil被引量：11
《Pedosphere》2009年第5期623-630,共8页WANG Jin-Hua DING Hui LU Yi-Tong SHEN Guo-Qing 
supported by the National Key Basic Research Program of China (No.2004CB418503);the National Natural Science Foundation of China (No.40801203)
Due to frequent soil Cd contamination and wide use of butachlor in China,there is a need to assess their combined toxicity to soil microorganisms.The combined effects of cadmium(Cd,10 mg kg-1 soil) and herbicide butac...
关键词：biomarkers microbial community diversity PHOSPHATASE random amplified polymorphic DNA analysis UREASE 
Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer被引量：8
《World Journal of Gastroenterology》2009年第12期1499-1505,共7页Ni Dai Ai-Ping Lu Cheng-Chao Shou Ji-You Li 
Supported by Grant for Key Technology Research and Development Program 2002BA711A06;National Basic Research Priorities Program 973 Project 1998051203;the Ministry of Science and Technology of China,and grant H020920030390,from the Beijing Science and Technology Commission
AIM： To investigate the prognostic significance of phosphatase regenerating liver 3 （PRL-3） protein expression in gastric cancer.METHODS： PRL-3 expression in paraffin-embedded tumor specimens from 293 patients wit...
关键词：Phosphatase regenerating liver 3 Gastriccancer PROGNOSIS RECURRENCE ANTIBODY 
rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells被引量：1
《Cell Research》2007年第11期919-932,共14页Yiyuan Yuan Xiang Gao Ning Guo Hui Zhang Zhiqin Xie Meilei Jin Baoming Li LeiYu Naihe Jing 
We thank Dr Bin Zhang （University of Michigan, USA） for providing the MCFD2 antibodies. This work was supported in part by the Life Science Special Fund of the Chinese Academy of Sciences for Human Genome Research （KJ95T-06 and KSCX1-Y02 to BML, NHJ and MLJ）, the National Natural Science Foundation of China （30225023 and 30430240 to BML and 90208011, 30300174, 30470856, 30421005 and 30623003 to NHJ）, the National Key Basic Research and Development Program of China （2006CB500807 to BML and 2002CB713802, 2005CB522704 and 2006CB943902 to NHJ）, the National High-Tech Research and Development Program of China （2006AA02ZI99 to BML and 2006AA02Z186 to NHJ）, the Shanghai Key Project of Basic Science Research （04DZ14005 to BML and 04DZ14005, 04DZ05608, 06DJI4001 and 06DZ22032 to NHJ）, the Council of the Shanghai Municipal for Science and Technology （05814578 to NHJ）, and the US National Institutes of Health （DA013471 and DA020555 to LY）.
Sac domain-containing proteins belong to a newly identified family of phosphoinositide phosphatases （the PIPPase family）. Despite well-characterized enzymatic activity, the biological functions of this mammalian Sac...
关键词：PIPPase intracellular membrane trafficking neurite outgrowth 
Utilization of Sparingly Soluble Phosphate by Red Cloverin Association with Glomus mosseae and Bacillus megaterium被引量：19
《Pedosphere》2002年第2期131-138,共8页YAOQING QINGFANGLING 等 
National Key Basic Research Support Foundation(NKBRSF)of China(No. G1999011807) ;the Joint Open Laboratory of Soil and Environment Between the Institute of Soil Science of the Chinese Academy of Sciences and the Hong Kong Baptist University. Presen
A pot experiment was conducted to investigate the mobilization ofsparingly soluble inorganic and organic sources of phosphorus (P) byred clover (Trifolium pratense L.) whose roots were colonized by thearbuscular mycor...
关键词：arbuscular mycorrhiza organicphosphorus PHOSPHATASE hosphate-solubilizing bacteria 
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