support from NIH P30 CA023168(Purdue University Center for Cancer Research);the NSERC grant(RGPIN-2021-02728(Jinrong Min)).
Protein arginine methyltransferases(PRMTs)are attractive targets for developing therapeutic agents,but selective PRMT inhibitors targeting the cofactor SAM binding site are limited.Herein,we report the discovery of a ...
This work was supported by the National Natural Science Foundation of China(31730110,31661143031,91940303,and 91753135);the Science and Technology Commission of Shanghai Municipality grant(17JC1404900,18XD1404400,and 20ZR1467300);a Joint Research grant with State Key Laboratory of Microbial Metabolism,School of Life Science and Biotechnology,Shanghai Jiao Tong University(MMLKF16-11).
Thousands of proteins undergo arginine methylation,a widespread post-translational modification catalyzed by several protein arginine methyltransferases(PRMTs).However,global understanding of their biological function...
supported by grants from the Research Grants Council of Hong Kong CUHK14167017,CUHK24100414 to H.Z.;the Shenzhen Innovation Committee of Science and Technology grants(JCYJ20150331101823691);Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research(2017B030301018)to Y.D
DEAR EDITOR Protein arginine methyltransferases (PRMTs)are involved in many cellular processes via the arginine methylation of histone or non-histone proteins.We examined the expression patterns of prmt4,prmt7,and prm...