supported by the National Natural Science Foundation of China(Nos.31802025,41977340,and 42277260).
Microplastics(MPs)are commonly found with hydrophobic contaminants in the water column and pose a serious threat to aquatic organisms.The effects of polystyrene microplastics of different particle sizes on the accumul...
supported by a grant from NIH to J.L(1 SC3 GM132056);by grants from National Natural Science Foundation of China to CMZ(32130026 and 92254305)
Xenopus has proven to be a remarkably versatile model organism in the realm of biological research for numerous years,owing to its straightforward maintenance in laboratory settings and its abundant provision of ample...
supported by the National Key R&D Program of China,Synthetic Biology Research(2019YFA0904500);Research Grants Council of Hong Kong(14119120,14112618,and CRF C5033-19E to H.Z.);Additional support was provided by the Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics,Chinese University of Hong Kong。
The biological function of the novel zinc-finger SWIM domain-containing protein family(ZSWIM)during embryonic development remains elusive.Here,we conducted a genome-wide analysis to explore the evolutionary processes ...
supported by the Fundamental Research Funds for the Central Universities(No.JUSRP51712B);the Natural Science Foundation of Xuzhou(No.KC19154);the Open Project Program of Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor,Ministry of Education,Guangxi Medical University(No.GKE-KF202006)。
Peptide dual agonists toward both glucagon-like peptide 1 receptor(GLP-1R)and glucagon receptor(GCGR)are emerging as novel therapeutics for the treatment of type 2 diabetes mellitus(T2DM)patients with obesity.Our prev...
This work was supported by the Centre National de la Recherche Scientifique(CNRS)and the Sorbonne University.
Cerberus is a multifunctional antagonist implicated in embryonic patterning through modulation of Nodal,BMP and Wnt signals.Although its function is largely conserved in chordates,certain activities have diverged,even...
supported by grants from the Research Grants Council of Hong Kong CUHK14167017,CUHK24100414 to H.Z.;the Shenzhen Innovation Committee of Science and Technology grants(JCYJ20150331101823691);Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research(2017B030301018)to Y.D
DEAR EDITOR Protein arginine methyltransferases (PRMTs)are involved in many cellular processes via the arginine methylation of histone or non-histone proteins.We examined the expression patterns of prmt4,prmt7,and prm...
supported by the National Natural Science Foundation of China (No. 21377153);the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB14040102)
There is a pressing need for developing in vivo or ex vivo assays to screen the glucocorticoid(GC) signaling disruption of chemicals. Thus, we aimed to establish an ex vivo assay for screening GC signaling disruptio...
To facilitate live imaging of demyelination and remyelination, we have generated a Xenopus laevis transgenic line, MBP-GFP-NTR, allowing conditional ablation of myelinating oligodendrocytes. In this line, the proximal...
The Na+/Ca2+ exchanger plays an important role in regulation of airway smooth muscle contraction by regulating intracellular calcium, and is a potential target for treatment of asthma. To test modulation of exchanger ...
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB14040102);the National Natural Science Foundation of China(No.21377153)
T3-induced Xenopus metamorphosis is an ideal model for detecting thyroid hormone(TH)signaling disruption of chemicals. To optimize the T3-induced Xenopus assay and improve its sensitivity and reproducibility, we int...