DISRUPTION

作品数：301被引量：649H指数：12
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相关领域：医药卫生更多>>
相关作者：谢勇陈样新王景峰陈菲卞欢更多>>
相关机构：中山大学孙逸仙纪念医院苏州大学江苏省农业科学院西安理工大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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Spinal cord injury–associated disruption of the autonomic immune control:Does biological sex matter?
《Neural Regeneration Research》2026年第1期298-299,共2页Sara Rito-Fernandes António J.Salgado Nuno A.Silva Susana Monteiro 
funded by the Santa Casa Neuroscience Awards—Prize Melo e Castro for Spinal Cord Injury Research(MC-18-2021)(to AJS and NAS);by the Wings for Life Spinal Cord Research Foundation(WFL-PT-14/23)(to NAS);funded by national funds through the Foundation for Science and Technology(FCT)—projects UIDB/50026/2020,UIDP/50026/2020,and EXPL/MED-PAT/0931/2021-http://doi.org/10.54499/EXPL/MED PAT/0931/2021;supported by the Norte Portugal Regional Operational Programme(NORTE 2020)under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund(ERDF)(to SM);the support given by the Portuguese Foundation of Science and Technology to SM(CEECIND/01902/2017-Doi:10.54499/CEECIND/01902/2017/CP1458/CT0024),and NAS(CEECIND/04794/2007)。
The impact of spinal cord injury(SCI)on the immune system is increasingly recognized in a field traditionally focused on motor impairments.SCI can seriously affect the immune system by progressively disrupting the reg...
关键词：MORTALITY SPINAL 
Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology
《Neural Regeneration Research》2025年第9期2589-2590,共2页Mikio Shimizu Tatsusada Okuno 
supported in port by the JSPS KAKENHI(grant number 22K07539 to MS);funded by Mitsubishi Tanabe Pharma Corporation。
Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal cord.Patients with ALS develop skeletal muscle we...
关键词：PARALYSIS SCLEROSIS 
Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke被引量：1
《Neural Regeneration Research》2025年第7期1944-1956,共13页Julia Castillo-González Elena González-Rey 
supported by the grants from the Spanish Ministry of Economy and Competitiveness(SAF2017-85602-R);the Spanish Ministry of Science and Innovation(PID2020-119638RB-I00 to EGR);FPU-program(FPU17/02616 to JCG)。
The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral circulation.It tightly modulates the ion transport and nutrient influx,while restricting...
关键词：blood–brain barrier disruption drug delivery ischemic stroke NEUROINFLAMMATION tight-junctions 
PathActMarker:an R package for inferring pathway activity of complex diseases
《Frontiers of Computer Science》2025年第3期123-124,共2页Xingyi LI Jun HAO Zhelin ZHAO Junming LI Xingyu LIAO Min LI Xuequn SHANG 
supported in part by the National Natural Science Foundation of China(Grant No.62202383);Guangdong Basic and Applied Basic Research Foundation(No.2024A1515012602);the National Key Research and Development Program of China(No.2022YFD1801200).
1 Introduction The process of complex diseases is closely linked to the disruption of key biological pathways,it is crucial to identify the dysfunctional pathways and quantify the degree of dysregulation at the indivi...
关键词：pathway activity DYSREGULATION complex diseases biological pathways disruption key biological pathwaysit identify dysfunctional pathways 
Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion
《Genes & Diseases》2025年第3期180-193,共14页Shengnan Hu Xueying Tang Fangrui Zhu Chen Liang Sa Wang Hongjie Wang Peifeng Li Yuzhen Li 
supported by grants from the National Natural Science Foundation of China(No.81970246,81470437).
Mitochondria serve as the energy provider and enable life activities,and they are the only organelles containing extra-chromosomal DNA.Each mitochondrion contains multiple copies of its genome,which is usually referre...
关键词：CARDIOMYOCYTE ISCHEMIA/REPERFUSION mtDNA Package Repair REPLICATION TRANSCRIPTION 
Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology
《Neural Regeneration Research》2025年第5期1407-1408,共2页Daniel Adam Felix Langerscheidt Hans Zempel 
TAU is a neuronal microtubule-associated protein preferentially located in axons.In a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosph...
关键词：ALZHEIMER TAU diseases 
Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly
《Neural Regeneration Research》2025年第5期1409-1410,共2页Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela 
Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic plasticity.AD has progressively been recognized as syna ptopathy and ...
关键词：ALZHEIMER PATHOLOGY 
Numerical study of runaway current impact on sawtooth oscillations in tokamaks
《Plasma Science and Technology》2025年第3期10-21,共12页Ruirui MA Chen ZHAO Yao ZHOU Chang LIU 
supported in part by the National Key R&D Program of China (No.2022YFE03040002);the Natural Science Foundation of Sichuan (No.2022NSFSC1814);National Natural Science Foundation of China (Nos.12305246,12175053 and 12261131622);the Italian Ministry of Foreign Affairs (No.CN23GR02);the Fundamental Research Funds for the Central Universities;supported by US Department of Energy (No.DE-AC0209CH11466)。
This study investigates the influence of runaway current in runaway plasmas on the dynamics of sawtooth oscillations and resultant loss of runaway electrons(RE)using the 3D magnetohydrodynamic(MHD)code M3D-C^(1)(Jardi...
关键词：DISRUPTION runaway current sawtooth oscillations RE loss 
Closed Reduction and Minimally Invasive Fixation for the Treatment of Bilateral Displaced Posterior Pelvic Ring Disruption
《Current Medical Science》2025年第1期137-145,共9页Zhen Wang Zhe Xu Peng-hui Xiang Mei-qi Gu Rui Zhang Hua Chen Li He Cheng-la Yi 
supported by the National Key Research and Development Program of China(2022YFC2504303);Innovation Foundation of National Clinical Research Center for Orthopaedics,Sports Medicine&Rehabilitation(2021-NCRC-CXJJ-ZH-24);Medical Innovation and Transformation Incubation Project of Tongji Hospital(2022ZHFY10).
Objective Close reduction and internal fixation have gained popularity for the treatment of pelvic fractures.However,the closed reduction of bilateral displaced posterior pelvic ring disruption is a great challenge ev...
关键词：Pelvic fractures Unlocking closed reduction technique Minimally invasive internal fixation 
The Value of Buyer Financing under Stochastic Component Cost in Supply Chains with Disruption Risk
《Journal of Systems Science and Systems Engineering》2025年第1期102-128,共27页Wei Cheng Jianbin Li Qihuang Mei Ziyi Wang 
supported in part by National Key R&D Program of China(2023YFB3308300,2023YFB3308301);the National Natural Science Foundation of China(72071085);Huazhong University of Science and Technology Double First-Class Funds for Humanities and Social Sciences(Digital Intelligence Decision Optimization Innovation Team,2021WKFZZX008);Ministry of Education Humanities and Social Science Research Youth Fund Project(24YJC630157);Hubei Provincial Social Science Fund Key Project and Provincial New Think Tank 2024 Project(HBSKJJ20241172);Huazhong University of Science and Technology Independent Innovation Research Fund(2023WKYXQN043).
This study delves into the dynamics of a supply chain scenario wherein a capital-abundant retailer extends buyer financing to a capital-constrained supplier. The supplier procures components from the spot market and s...
关键词：Buyer financing bank financing geometric Brownian motion DISRUPTION 
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