PROBENECID

作品数:6被引量:34H指数:4
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相关领域:医药卫生更多>>
相关作者:谢佩蓉陈政良更多>>
相关机构:第三军医大学更多>>
相关期刊:《免疫学杂志》《Journal of Food Science and Engineering》《Acta Pharmacologica Sinica》《American Journal of Analytical Chemistry》更多>>
相关基金:国家自然科学基金北京市自然科学基金更多>>
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TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson’s disease被引量:19
《Acta Pharmacologica Sinica》2019年第12期1503-1512,共10页Qian-hang Shao Ying Chen Fang-fang Li Shuo Wang Xiao-ling Zhang Yu-he Yuan Nai-hong Chen 
the National Natural Science Foundation of China(81573640,81773925);the Beijing Natural Science Foundation(7161011);the Drug Innovation Major Project 2018ZX09711-001-001,2018ZX09711-001-001-003.
Parkinson's disease(PD)is a multifactorial disorder characterized by progressive loss of dopaminergic(DA)neurons in the substantia nigra pars compacta(SNpc)and the presence of Lewy bodies(LBs)consisting of misfolded ...
关键词:Parkinson's disease Toll-like receptor 4 MPTP/probenecid mouse model Α-SYNUCLEIN oxidative stress glial activation NF-κB NEUROINFLAMMATION 
NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP被引量:4
《Acta Pharmacologica Sinica》2019年第8期991-998,共8页Ying Chen Qiu-shuang Zhang Qian-hang Shao Shuo Wang Yu-he Yuan Nai-hong Chen Hong-bo Wang 
supported by the National Natural Science Foundation of China (81573640,81773925,and U1402221);the Beijing Natural Science Foundation (7161011);Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education (P201701)
Olfactory bulb,as one of sensory organs opening to the outside,is susceptible to toxic environment and easy to deteriorate.Recent studies in Parkinson’s disease(PD)patients and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyr...
关键词:Parkinson’s disease olfactory bulb Α-SYNUCLEIN TLR4 NF-κB NLRP3 NEUROINFLAMMATION MPTP PROBENECID 
Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters(OATs)被引量:7
《Acta Pharmaceutica Sinica B》2019年第5期986-996,共11页Xiaokui Huo Qiang Meng Changyuan Wang Yanna Zhu Zhihao Liu Xiaodong Ma Xiaochi Ma Jinyong Peng Huijun Sun Kexin Liu 
supported by a grant from the National Natural Science Foundation of China,China(Nos.81874324,81473280,and U1608283);Dalian Science and technology innovation found,China(No.2018J12SN065)
Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I(DHP-I),was developed. In present stud...
关键词:Imipenem CILASTATIN PROBENECID OATS H OAT1 H OAT3 NEPHROTOXICITY 
Antihyperuricemic Effect of Ethanol Extract of Snake Fruit (Salacca edulis Reinw.) var. Bongkok on Wistar Male Rat
《Journal of Food Science and Engineering》2012年第5期271-276,共6页Leni Herliani Afrianti Priyatno Elin Yulinah Sukandar Slamet Ibrahim I Ketut Adnyana 
The aim of the study was to investigate antihyperuricemic effect of snake fruit (Salacca edulis Reinw.) var. Bongkok Wistar male rates. Antihyperuricemic investigation on Wistar male rats showed that administration ...
关键词:Snake fruit var. Bongkok ethanol extract antihyperuricemic PROBENECID Wistar male rat. 
Determination of 8 Diuretics and Probenecid in Human Urine by Gas Chromatography-Mass Spectrometry: Confirmation Procedure被引量:2
《American Journal of Analytical Chemistry》2012年第4期320-327,共8页Olga Zaporozhets Iuna Tsyrulneva Mykola Ischenko 
A fast and sensitive method for determination of 8 diuretics (acetazolamide, bendroflumethiazide, bumetanide, chlorthalidone, furosemide, hydrochlorothiazide, metolazone, triamterene) and masking agent (probenecid) in...
关键词:DIURETICS URINE Gas CHROMATOGRAPHY Tandem Mass SPECTROMETRY CONFIRMATION 
应用Fura-2/AM和Probenecid测定免疫细胞胞浆游离Ca^(2+)浓度被引量:4
《免疫学杂志》1995年第4期256-258,共3页陈政良 谢佩蓉 
全军"八五"医药卫生科研基金
人B细胞系Raji和MΦ系U937细胞可将负载于胞内的Ca ̄(2+)荧光示踪剂Fura-2外排和房室化,质膜有机阴离子转运系统抑制剂Probenecid能阻断这些过程,而且对细胞Ca ̄(2+)应答无不良影响。提示Ra...
关键词:钙离子 PROBENECID Fura-2示踪法 B淋巴细胞 
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