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PROTEIN: 作品数：2328被引量：5787H指数：25; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：邢苗李根喜刘晓灵梁毅杨芃原更多>>; 相关机构：中国科学院北京大学第二军医大学复旦大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

Killing pluripotent stem cells by BET protein inhibition: 《Science Bulletin》2018年第8期459-461,共3页Shufeng Ma Ying Lin Zhili Rong; the support from the Department of Science and Technology of Guangdong Province(2014B020212018);the Natural Science Foundation of Guangdong(2017A030310331);the Guangzhou Science Technology and Innovation Commission(201508020120); Human pluripotent stem cells(h PSCs),including embryonic stem cells(ESCs)and induced pluripotent stem cells(i PSCs),are capable of unlimited self-renewal and able to differentiate into all cell types in human body[1],...; 关键词：干细胞蛋白质 MIRNA 风险源房间衍生物专业版小分子

Microfluidic generation of egg-derived protein microcarriers for 3D cell culture and drug delivery被引量：11: 《Science Bulletin》2017年第18期1283-1290,共8页Yuxiao Liu Qian Huang Jie Wang Fanfan Fu Jianan Ren Yuanjin Zhao; supported by the National Natural Science Foundation of China (21473029, 51522302);the NSAF Foundation of China (U1530260);the Natural Science Foundation of Jiangsu Province (BK20140028);the Program for New Century Excellent Talents in University;the Scientific Research Foundation of Southeast University; Microcarriers have a demonstrated value for biomedical applications,in particular for drug delivery and three-dimensional cell culture.Attempts to develop this technique tend to focus on the fabrication of functional ...; 关键词：Microfluidics Microcarriers Drug delivery Cell culture Egg white

Protein corona in vivo: dynamic complement proteins-mediated opsonization and immune modulation被引量：5: 《Science Bulletin》2017年第14期976-977,共2页Rong Cai Chunying Chen; supported by the National Basic Research Program of China(2016YFA0201600);the Chinese Academy of Sciences Key Research Program for Frontier Sciences(QYZDJ-SSSLH022),the Chinese Academy of Sciences Interdisciplinary Innovation Team;the National Science Fund for Distinguished Young Scholars(11425520); It has been well-established that blood biomolecules deposit on the surface of nanoparticles forming a protein rich layer,known as‘‘protein corona',which directly interacts with and is recognized by cells.These inte...; 关键词：蛋白质免疫调节调理作用介导补体啤酒体内纳米颗粒

Magnetogenetics: remote non-invasive magnetic activation of neuronal activity with a magnetoreceptor被引量：22: 《Science Bulletin》2015年第24期2107-2119,共13页Xiaoyang Long Jing Ye Di Zhao Sheng-Jia Zhang; supported by Tsinghua-Peking Center for Life Sciences;IDG/Mc Govern Foundation;the National Natural Science Foundation of China; Current neuromodulation techniques such as optogenetics and deep-brain stimulation are transforming basic and translational neuroscience. These two neuro- modulation approaches are, however, invasive since surgical im...; 关键词：Magnetogenetics - Optogenetics Iron-sulfur cluster assembly protein Magnetoreceptor Non-invasive and remote activation Neuronalactivity and circuit

Efficient and reproducible folding simulations of the Trp-cage protein with multiscale molecular dynamics被引量：1: 《Chinese Science Bulletin》2008年第11期1699-1707,共9页XIA XueFeng ZHANG Song HUANG Bo ZHOU Yun SUN ZhiRong; National High Technology Research and Development Program of China (Grant No. 2006AA020403);the National Basic Research Program of China (Grant No. 2003CB715900);National Natural Science Foundation of China (Grant No. 30770498); Folding simulations are often time-consuming or highly sensitive to the initial conformation of the si-mulation even for mini protein like the Trp-cage. Here, we present a multiscale molecular dynamics method which ap...; 关键词：蛋白质分子动力学分子结构结构模拟

Localization of NOS-like protein in guard cells of Vicia faba L.and its possible function被引量：5: 《Chinese Science Bulletin》2007年第1期84-90,共7页LIU Xin WANG YouQun JIA WenSuo LOU ChengHou ZHANG ShuQiu; Supported by the National Natural Science Foundation of China (Grant No. 30370141); Using the immuno-fluorescence and immuno-gold electron microscope technology, localization of ni- tric oxide synthase (NOS)-like proteins was determined in guard cells of Vicia faba L. NOS is mainly localized in nucle...; 关键词：免疫细胞氧化一氮连位化合物生物化学

RadA:A protein involved in DNA damage repair processes of Deinococcus radiodurans R1被引量：3: 《Chinese Science Bulletin》2006年第24期2993-2999,共7页ZHOU Qing ZHANG Xinjue XU Hong XU Bujin HUA Yuejin; Acknowledgements The authors would like to thank Prof. Fu Junjie （Radiation Center of Zhejiang University） for his help in irradiation treatment. This work was supported by the National Basic Research Program of China （Grant No. 2004CB19604）, a grant for Distinguished Young Scientist of China （Grant No. 30425038） and the National Natural Science Foundation of China （Grant No. 30330020）.; RadA is highly conserved in bacteria and belongs to the RecA/RadA/Rad51 protein su-perfamily found in bacteria,archaea and eukarya. In Archaea,it plays a critical role in homologous re-combination process due to its R...; 关键词：DNA损伤修复 RadA蛋白细菌同源重组

PAS domain of the deduced Org35 protein mediates the interaction with NifA被引量：1: 《Chinese Science Bulletin》2006年第9期1141-1144,共4页TU Ran CUI Yanhua CHEN Sanfeng LI Jilun; This work was supported by the National Natural Science Foundation of China （Grant No. 30470028）.; NifA in Azospirillum brasilense plays a key role in regulating the synthesis of nitrogenase in response to ammonia and oxygen available. Recently, our laboratory has identified four clones, whose gene prodcuts interac...; 关键词：NIFA 固氮螺菌属酵母激酶 PAS

Origin and evolution of new exons in the rodent zinc fingerprotein 39 gene被引量：3: 《Chinese Science Bulletin》2005年第11期1126-1130,共5页PENG Lixin ZHENG Hongkun LI Xin YANG Shuang CHEN Hong WANG Wen; the program of the CAS-Max Planck Junior Scientist Group,the keyproject of the CAs(Grant No.KSCx2-SW-121); the National Natural Science Foundation of China(Grant Nos.30325016&30430400).; The origin of new structures and functions is an important process in evolution. In the past decades, we have obtained some preliminary knowledge of the origin and evo- lution of new genes. However, as the basic unit ...; 关键词：核苷酸序列啮齿动物动物起源动物进化蛋白质因子

Oligomerization study of NHR3 and NHR4 domains from ETO protein involved in t(8;21)-associated acute myeloid leukemia被引量：1: 《Chinese Science Bulletin》2005年第9期875-879,共5页WUDonghui YANGHaitao XUEXiaoyu LIANGWenxue MIAOXiaoyu CHENSaijuan PANGHai; This work was supported by the National Natural Science Foundation of China(Grant No.30370300).; Little had been known about ETO protein until t(8;21) was found in 12%―15% of acute myeloid leukemia which resulted in AML1-ETO fusion protein. ETO protein has four conserved nervy homology regions termed NHR1― 4. A...; 关键词：白血病 NHR3 NHR4 发病机理治疗方法蛋白质

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