PROTEIN

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Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1被引量：1
《Science China(Life Sciences)》2024年第3期475-487,共13页Hao-Xiang Yuan Ya-Ting Chen Yu-Quan Li Yan-Sheng Wang Zhi-Jun Ou Yan Li Jian-Jun Gao Meng-Jie Deng Yuan-Kai Song Li Fu Hong-Bo Ci Feng-Jun Chang Yang Cao Yu-Peng Jian Bi-Ang Kang Zhi-Wei Mo Da-Sheng Ning Yue-Ming Peng Ze-Long Liu Xiao-Jun Liu Ying-Qi Xu Jun Xu Jing-Song Ou 
supported by the National Key Research and Development Program of China(2021YFA0805100);the National Natural Science Foundation of China(81830013,81770241,81970363,82000362,92268202,81170271,81370370,81490531,81670392,81600382);the National Natural Science Foundation of China Distinguished Young Scholar Grant(81325001);“973 Project”from the Ministry of Science and Technology of China(2009CB522104);Guangdong Basic and Applied Basic Research Foundation,China(2019B1515120092);the Science and Technology Planning Project of Guangzhou,China(202103000016);the Changjiang Scholars Program from the Ministry of Education of China;the Sun Yat-sen University Clinical Research 5010 Program;the Program of National Key Clinical Specialties。
Cardiopulmonary bypass has been speculated to elicit systemic inflammation to initiate acute lung injury(ALI), including acute respiratory distress syndrome(ARDS), in patients after cardiac surgery. We previously foun...
关键词：cell-derived extracellular vesicles acute lung injury acute respiratory distress syndrome cardiopulmonary bypass follistatin-like protein 1 
SecReT6 update:a comprehensive resource of bacterial TypeⅥSecretion Systems被引量：3
《Science China(Life Sciences)》2023年第3期626-634,共9页Jianfeng Zhang Jiahao Guan Meng Wang Gang Li Marko Djordjevic Cui Tai Hui Wang Zixin Deng Zhaoyan Chen Hong-Yu Ou 
supported by the Science and Technology Commission of Shanghai Municipality(19430750600,19JC1413000);the National Natural Science Foundation of China(31670074);the Medical Excellence Award Funded by the Creative Research Development Grant from the First Affiliated Hospital of Guangxi Medical University(XK2019025);the Science Fund of the Republic of Serbia(7750294,q-bio BDS)。
TypeⅥSecretion System(T6SS)plays significant roles in microbial activities via injecting effectors into adjacent cells or environments.T6SS increasingly gained attention due to its important influence on pathogenesis...
关键词：TypeⅥSecretion System T6SS-related protein DATABASE prediction Acinetobacter baumannii 
WUSCHEL: the versatile protein in the shoot apical meristem
《Science China(Life Sciences)》2021年第1期177-178,共2页Lin Xu 
supported by grants from the National Natural Science Foundation of China(31630007);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB27030103);the Key Research Program of CAS(QYZDB-SSW-SMC010);National Key Laboratory of Plant Molecular Genetics。
In vascular plants, almost all above-ground organs are derived from the shoot apical meristem (SAM). The developmental role of the SAM has been extensively studied,especially in the model dicot plant Arabidopsis thali...
关键词：VERSATILE ORGANS 
Design and biosynthesis of functional protein nanostructures被引量：5
《Science China(Life Sciences)》2020年第8期1142-1158,共17页Feng Li Dianbing Wang Juan Zhou Dong Men Xian-En Zhang 
supported by the National Natural Science Foundation of China(21890743,31771103,and 91527302);the National Key Research and Development Program of China(2017YFA0205503);the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB29050100);CAS Emergency Project of ASF Research(KJZD-SWL06 and KJZD-SWL07);Youth Innovation Promotion Association of CAS(2014308);Wuhan Huanghe Talents Program of Science and Technology。
Proteins are one of the major classes of biomolecules that execute biological functions for maintenance of life.Various kinds of nanostructures self-assembled from proteins have been created in nature over millions of...
关键词：protein nanostructures protein nanowires S-LAYER protein nanocages self-assembly BIOSYNTHESIS FUNCTIONALIZATION 
Protein trafficking in plant cells:tools and markers被引量：3
《Science China(Life Sciences)》2020年第3期343-363,共21页Dongmei Zhu Mengdi Zhang Caiji Gao Jinbo Shen 
This work was supported by the National Natural Science Foundation of China(31970181);the Zhejiang Provincial Natural Science Foundation of China(R20C020001);the National Key Research and Development Program of China(2018YFD1000604);the Zhejiang Agricultural and Forestry University Starting Funding(2018FR029).
Eukaryotic cells consist of numerous membrane-bound organelles,which compartmentalize cellular materials to fulfil a variety of vital functions.In the post-genomic era,it is widely recognized that identification of th...
关键词：PROTEIN SUBCELLULAR LOCALIZATION ORGANELLE MARKERS ENDOMEMBRANE system 
CLIP: viewing the RNA world from an RNA-protein interactome perspective被引量：2
《Science China(Life Sciences)》2015年第1期75-88,共14页ZHANG Yin XIE ShuJuan XU Hui QU LiangHu 
supported by the National Natural Science Foundation of China(31200593,31230042);the Guangdong Natural Science Foundation (S2011040001760);the Fundamental Research Funds for the Central Universities (13lgpy40);the National Basic Research Program of China (2011CB811300)
The pervasive transcription of the genome creates many types of non-coding RNAs(nc RNAs).However,we know very little regarding the functions and the regulatory mechanisms of these nc RNAs.Exploring the interactions of...
关键词：CLIP CLASH RPBs nc RNAs functional RNomics 
Rapid development of proteomics in China: from the perspective of the Human Liver Proteome Project and technology development被引量：3
《Science China(Life Sciences)》2014年第12期1162-1171,共10页LI Ning XU Zhong Wei ZHAI Lin Hui LI Yan Chang FAN Feng Xu ZHENG Jun Jie XU Ping HE Fu Chu 
funded by the Chinese National Basic Research Program grants(2011CB910600,2013CB911201)to Xu Ping and Li Ning respectively;the grants of National Natural Science Foundation of China(31070673,31170780)to Xu Ping
Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than oth...
关键词：PROTEOMICS LC-MS/MS HLPP protein-protein interaction protein posttranslational modification BIOINFORMATICS 
Statistical analyses of protein folding rates from the view of quantum transition被引量：1
《Science China(Life Sciences)》2014年第12期1197-1212,共16页LV Jun LUO Liao Fu 
supported by the Distinguished Scientist Award of Inner Mongolia Autonomous Region(2008)
Understanding protein folding rate is the primary key to unlock the fundamental physics underlying protein structure and its folding mechanism.Especially,the temperature dependence of the folding rate remains unsolved...
关键词：quantum folding protein folding rate temperature dependence number of torsion mode folding free energy 
A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5被引量：2
《Science China(Life Sciences)》2013年第12期1124-1133,共10页WU LianQiu ZHANG XueMei CHE YanChun ZHANG Ying TANG SongQing LIAO Yun NA RuiXiong XIONG XiangLin LIU LongDing LI QiHan 
supported by the National Basic Research Program of China(2012CB518901);the National Natural Science Foundation of China(31100127)
Studies of herpes simplex virus type 1 （HSV-1） infection have shown that many known and unknown cellular molecules in- volved in viral proliferation are up-regulated following HSV-1 infection. In this study, using t...
关键词：herpes simplex virus type 1 （HSV-1） HSV-1 infection response repressive protein （HIRPP） ATF5 transcriptional regulation 
pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells被引量：27
《Science China(Life Sciences)》2013年第5期460-466,共7页ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing 
supported by the National Natural Science Foundation of China(30970165,81102230);Team Project for the Technology Innovation of Higher Education of Hunan Province,China,2010
Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy. Pathogenesis of infection has been mostly attributed to excessive cytok...
关键词：Chlamydia trachomatis pORF5 plasmid protein mitogen-activated protein kinase proinflammatory cytokines TLR2 
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