PROTEIN

作品数：2328被引量：5787H指数：25
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Protein@PP-Zn nanocomplex assembled by coordination of zinc ions used for intracellular protein delivery被引量：2
《Science China Chemistry》2023年第8期2354-2362,共9页Liyun Cui Sainan Liu Fan Wu Hua Chen Yuanfeng Li Linqi Shi Yong Liu Rujiang Ma 
supported by the National Natural Science Foundation of China(51773099,52203184,22275043,51933006)。
In recent years,intracellular delivery of protein drugs has attracted great attention,and polymer-based systems have been extensively exploited to develop efficient and safe carriers.However,efficient intracellular de...
关键词：PROTEIN zinc ions intracellular delivery COORDINATION POLYMER 
Genetically engineered materials:Proteins and beyond被引量：2
《Science China Chemistry》2022年第3期486-496,共11页Jingjing Wei Lianjie Xu Wen-Hao Wu Fei Sun Wen-Bin Zhang 
supported by the National Natural Science Foundation of China(21905001,21925102,21991132,92056118);the National Key R&D Program of China(2020YFA0908100);Beijing Municipal Natural Science Foundation(L182003);Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM-202006);Guangdong Natural Science Foundation(GDST19EG22);the Science,Technology,and Innovation Commission of Shenzhen Municipality(JCYJ20190813094601656);Clinical Medicine Plus X project of Peking University;Fundamental Research Funds for the Central Universities。
Information-rich molecules provide opportunities for evolution.Genetically engineered materials are superior in that their properties are coded within genetic sequences and could be fine-tuned.In this review,we elabor...
关键词：PROTEIN genetic engineering SELF-ASSEMBLY living materials 
Combinatorial synthesis of redox-responsive cationic polypeptoids for intracellular protein delivery application被引量：1
《Science China Chemistry》2020年第11期1619-1625,共7页Zhicheng Le Tong Xiao Zhijia Liu Xingliang Liu Hong Liu Lixin Liu Yongming Chen 
This work was supported by the National Natural Science Foundation of China(51803243,51820105004);the Guangdong Basic and Applied Basic Research Foundation(2020A1515011285);the Guangdong Innovative and Entrepreneurial Research Team Program(2013S086).
Biologics play an essential role in treating various indications from cancers to the metabolic diseases,while the current development of new classes of intracellular-acting protein drugs is still hindered because of h...
关键词：multicomponent reaction cationic polypeptoid redox-responsive intracellular delivery PROTEIN 
Peptide asparaginyl ligases——renegade peptide bond makers被引量：2
《Science China Chemistry》2020年第3期296-307,共12页James P.Tam Ning-Yu Chan Heng Tai Liew Shaun J.Tan Yu Chen 
supported by Academic Research Grant Tier 3(MOE2016-T3-1-003)from the Singapore Ministry of Education.
Making peptide bonds is tightly controlled by genetic code and machinery which includes cofactors,ATP,and RNAs.In this regard,the stand-alone and genetic-code-independent peptide ligases constitute a new family of ren...
关键词：asparaginyl ENDOPEPTIDASE Asn-specific LIGATION bioorthogonal LIGATION butelase CHEMOENZYMATIC LIGATION live-cell LABELING PROTEIN engineering PROTEIN modification site-specific LABELING tandem LIGATION 
Two-dimensional ultraviolet spectroscopy of proteins被引量：1
《Science China Chemistry》2018年第9期1099-1109,共11页Jin Xiao Zhang Edward Sharman Jun Jiang 
supported by the National Natural Science Foundation of China (21703221, 21473166);Hefei Science Center CAS (2016HSC-IU012)
Two-dimensional ultraviolet(2 DUV) spectroscopy is a novel technology for probing molecular structure. We have developed a generalized quantum mechanics/molecular mechanics(QM/MM) approach to simulate the electronic t...
关键词：two-dimensional ultraviolet spectroscopy（2DUV） quantum mechanics/molecular dynamics（QM/MM） PROTEIN molecular structure and dynamics 
Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis被引量：3
《Science China Chemistry》2018年第6期702-707,共6页Chen-Chen Chen Shuai Gao Hua-Song Ai Qian Qu Chang-Lin Tian Yi-Ming Li 
supported by the National Natural Science Foundation of China (21572043, 21473176);the Ministry of Science and Technology (2016YFA0400900, 2015CB910103);the Fundamental Research Funds for the Central Universities (PA2017GDQT0021)
Snake toxin Calciseptine as a natural antagonist of L-type calcium channel has potential drug values, but its structural information remains unknown. Here, we report the total chemical synthesis of Calciseptine by usi...
关键词：protein chemical synthesis calciseptine hydrazide based native chemical ligation racemic protein crystallography 
Recent developments in peptide ligation independent of amino acid side-chain functional group被引量：3
《Science China Chemistry》2018年第1期97-112,共16页Jinhua Yang Junfeng Zhao 
supported by the National Natural Science Foundation of China (21462023), and the Natural Science Foundation of Jiangxi Province (20143ACB20007, 20153BCB23018)
Chemical synthesis of peptides and proteins has evolved into an indispensable tool for chemical biology. Peptide ligation is a straightforward technique for joining two short peptide fragments together via a native pe...
关键词：peptide ligation amide bond formation independent of side-chain functional group amino acid PROTEIN 
Chemical synthesis of histone H2A with methylation at Gln104
《Science China Chemistry》2017年第5期621-627,共7页Qiaoqiao He Jiabin Li Yunkun Qi Zhipeng Wang Yong Huang Lei Liu 
supported by the National Basic Research Program of China(2013CB932800);the National Natural Science Foundation of China(21532004,21225207,81621002)
Histone H2A methylation at Glnl04 （H2AQ104Me） is a new type of histone post-translational modification （PTM） discovered recently. This modification has been found to have significant influence on gene transcriptio...
关键词：protein chemical synthesis glutamine methylation histone H2A thermal stability 
Comparison of reduced point charge models of proteins: Molecular Dynamics simulations of Ubiquitin
《Science China Chemistry》2014年第10期1340-1354,共15页LEHERTE Laurence VERCAUTEREN Daniel P. 
Reduced point charge models of amino acids are used to model Ubiquitin （PDB： 1UBQ）. They are designed （i） from local ex- tremum positions in charge density （CD） distribution functions built from the Poisson equ...
关键词：molecular electrostatic potential electron density smoothing of molecular fields critical points point charge model PROTEIN UBIQUITIN 
On the molecular mechanism of ion specific Hofmeister series被引量：2
《Science China Chemistry》2014年第1期36-47,共12页XIE WenJun LIU ChengWen YANG LiJiang GAO YiQin 
National Fund for Fostering Talents of Basic Sciences(J0630421);the National Natural Science Foundation of China(21125311);the National Basic Research Program of China(2012CB917304)for financial support
Hofmeister series ranks the ability of salt ions in influencing a variety of properties and processes in aqueous solutions.In this review,we reexamine how these ions and some other small molecules affect water structu...
关键词：Hofmeister series salt effects ion cooperativity hydrogen DONOR ACCEPTOR equilibrium surface tension protein dena-turant protein protectant 
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