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Toward understanding the role of genomic repeat elements in neurodegenerative diseases: 《Neural Regeneration Research》2025年第3期646-659,共14页Zhengyu An Aidi Jiang Jingqi Chen; supported by the National Natural Science Foundation of China, No.61932008;Natural Science Foundation of Shanghai, No.21ZR1403200 (both to JC)。; Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage se...; 关键词：Alzheimer's disease ATAXIA deep learning long-read sequencing NEURODEGENERATION neurodegenerative diseases Parkinson's disease repeat element structural variant

Factors Influencing the Choice of Mode of Delivery in Women with Repeat Pregnancies after Cesarean Delivery: 《Open Journal of Obstetrics and Gynecology》2025年第2期213-223,共11页Wenli Chen; The increasing rate of cesarean delivery has become a widespread concern worldwide, nearly half of which is due to previous cesarean deliveries, and elective repeat cesarean delivery (ERCD), which is the main option f...; 关键词：Trial of Labor after Cesarean Section Elective Repeat Cesarean Delivery Influence Factor

GGN repeat length of the androgen receptor gene is associated with antral follicle count in Chinese women undergoing controlled ovarian stimulation: 《南方医科大学学报》2025年第2期213-222,共10页LIU Xinyan FAN Qi DENG Mingfen XU Yan GUO Jing CAO Ping ZHOU Canquan XU Yanwen; 国家自然科学基金(82001551)。; Objective To evaluate the association of GGN repeat polymorphism of androgen receptor(AR)with ovarian reserve and ovarian response in controlled ovarian stimulation(COS).Methods This genetic association study was cond...; 关键词：androgen receptor GGN polymorphism ovarian reserve ovarian stimulation

Computational optimization of a pan-coronavirus fusion inhibitory peptide targeting spike's heptapeptide repeat region: 《Biosafety and Health》2025年第1期44-58,共15页Peixiang Gao Shuo Liu Xiaojing Chi Xinhui Zhang Xiuying Liu Xuehua Yang Huarui Duan Jingya Zhou Weijin Huang Wei Yanag; supported by the National Natural Science Foundation of China(U22A20553 and 82241064);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-038, 2022-I2M-1-021).; In the past two decades,highly pathogenic coronaviruses(CoVs),such as severe acute respiratory syndrome coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and severe acute respiratory syndrom...; 关键词：Coronaviruses(CoVs) Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Fusion inhibitors Computational design

Delivery Modes and Their Effects on Mothers and Neonates in Cases of Repeat Pregnancy with Uterine Scars: 《Journal of Clinical and Nursing Research》2025年第1期27-31,共5页Hongyu Wang Tiantian Chen; Objective:To investigate the delivery modes of women with repeat pregnancies involving uterine scars and their effects on both mothers and neonates.Methods:A study was conducted on 100 patients treated at Shenzhen Mat...; 关键词：Uterine scars Repeat pregnancy Delivery mode Cesarean section Vaginal delivery

Is 26S proteasome non-ATPase regulatory subunit 6 a potential molecular target for intrahepatic cholangiocarcinoma?: 《World Journal of Hepatology》2024年第11期1219-1224,共6页Yong-Zhi Zhuang Li-Quan Tong Xue-Ying Sun; Supported by The National Key Research and Development Program of China,No.2017YFC1308602;The Research Funds by the Fifth Affiliated Hospital of Harbin Medical University,No.2022-002 and No.2023-001.; In this editorial we comment on the article by Tang et al published in the recent issue of World Journal of Hepatology.Drug therapy of intrahepatic cholangiocarcinoma(iCCA)poses an enormous challenge since only a smal...; 关键词：CHOLANGIOCARCINOMA 26S proteasome non-ATPase regulatory subunit 6 Molecular targeted therapies Proteasome inhibitors Clustered regularly interspaced short palindromic repeat

Overexpression of proteasome 26S subunit non-ATPase 6 protein and its clinicopathological significance in intrahepatic cholangiocarcinoma被引量：1: 《World Journal of Hepatology》2024年第11期1282-1289,共8页Zhong-Qing Tang Yu-Lu Tang Kai Qin Qi Li Gang Chen Yu-Bin Huang Jian-Jun Li; BACKGROUND Currently,intrahepatic cholangiocarcinoma(ICC)poses a continuing,significant health challenge,but the relationship has yet to be established between ICC and the proteasome 26S subunit non-ATPase 6(PSMD6).AI...; 关键词：Intrahepatic cholangiocarcinoma Proteasome 26S subunit non-ATPase 6 Immunohistochemistry Clustered regularly interspaced short palindromic repeat knockout screening Clinicopathological characteristics

Social and Behavioural Determinants for Occurrence of Repeat Pregnancy among Adolescents in Suna East-Migori County, Kenya: 《Open Journal of Nursing》2024年第10期530-547,共18页Samuel Oyugi John Arudo Milicent Ambetsa; Introduction: A repeat pregnancy at adolescent age often comes with much stress and complications. It feeds into a cycle of psychological trauma and socio-economic deprivation that compromises the life of the young mo...; 关键词：ADOLESCENT PREGNANCY Fertility CONTRACEPTION Gender-Based-Violence

Centromere Landscapes Resolved from Hundreds of Human Genomes: 《Genomics, Proteomics & Bioinformatics》2024年第5期61-71,共11页Shenghan Gao Yimeng Zhang Stephen J. Bush Bo Wang Xiaofei Yang Kai Ye; supported by the National Key R&D Program of China(Grant No.2022YFC3400300);the National Natural Science Foundation of China(Grant Nos.32125009,32400520,32422019,62172325,32070663,32200510);the Natural Science Foundation of Shaanxi Province(Grant No.2024JC-JCQN-28);the Fundamental Research Funds for the Central Universities(Grant No.xzy012024088);China.; High-fidelity(HiFi)sequencing has facilitated the assembly and analysis of the most repetitive region of the genome,the centromere.Nevertheless,our current understanding of human centromeres is based on a relatively s...; 关键词：Centromere sequence Genome evolution High-fidelity sequencing technology Higher order repeat annotation Human population

Decoding the genetic landscape of autism:A comprehensive review: 《World Journal of Clinical Pediatrics》2024年第3期98-136,共39页Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Eman A Bediwy Reem Elbeltagi; BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental condition characterized by heterogeneous symptoms and genetic underpinnings.Recent advancements in genetic and epigenetic research have provided ...; 关键词：Autism spectrum disorder GENETICS EPIGENETICS Clustered Regularly Interspaced Short Palindromic Repeats-Cas9 Gene-environment interactions Personalized medicine

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