This work was partially supported by National Natural Science Foundation of China 81874325(Zhi-ping Li),81872915(Ming-Wei Wang),82073904(Ming-Wei Wang),81973373(De-hua Yang),82121005(De-hua Yang)and 21704064(Qing-tong Zhou);The Science and Technology Commission of Shanghai Municipality 18DZ1910604(Zhi-ping Li),19XD1400900(Zhi-ping Li)and 19DZ1910604(Zhi-ping Li);National Science and Technology Major Project of China-Key New Drug Creation and Manufacturing Program 2018ZX09735-001(Ming-Wei Wang),2018ZX09711002-002-005(De-hua Yang)and 2018ZX09711002-002-011(Qing Liu);the National Key Basic Research Program of China 2018YFA0507000 (Ming-Wei Wang).
Inflammatory bowel disease(IBD)is a global health burden whose existing treatment is largely dependent on anti-inflammatory agents.Despite showing some therapeutic actions,their clinical efficacy and adverse events ar...
supported by the Ministry of Science and Technology of China(2022ZD0205203)。
Connectome-scale structural mapping is fundamental for understanding the underlying mechanisms of brain cognition and brain disease pathogenesis.By combining rapidly developing three-dimensional(3D)imaging techniques ...
supported by the National Basic Research Program of China(973 Project;2015CB755602);the National Natural Science Foundation of China(61721092,61890953,31871088,and 81871082);Key-Area Research and Development Program of Guangdong Province(2019B030335001);CAMS Innovation Fund for Medical Sciences(2019-I2M-5-014);the Director Fund of Wuhan National Laboratory for Optoelectronics。
To decipher the organizational logic of complex brain circuits,it is important to chart long-distance pathways while preserving micron-level accuracy of local network.However,mapping the neuronal projections with indi...
supported by the National Key Research and Development Program of China(2017YFA0503700);the Chinese Academy of Sciences Key Research Program of Frontier Sciences(QYZDY-SSW-SMC003);a Strategic Priority Research Program of CAS(XDB17000000);a National Basic Research Program of China(2015CB150100);the National Natural Science Foundation of China(31622007,31670237,32070267);the Youth Innovation Promotion Association of CAS(2020081);Taishan Scholars Project,Jinan Science and Technology Project(2020GXRC058);the Natural Science Foundation of Shandong Province China(ZR2019ZD48).
Photosystem I(PSI)is one of the two photosystems in photosynthesis,and performs a series of electron transfer reactions leading to the reduction of ferredoxin.In higher plants,PSI is surrounded by four light-harvestin...
The study was supported by the Beijing Advanced Innovation Center for Genomics at Peking University;We sincerely thank Fei Wang and Xuefang Zhang from the National Center for Protein Sciences Beijing(Peking University)for assisting with the FACS analysis;Part of the bioinformatic analyses were run on the Computing Platform of the Center for Life Science;The study was supported by the Beijing Municipal Science and Technology Commission(Z181100001318001);the National Natural Science Foundation of China(31625018,31890781,81521002 and 81730038);the National Basic Research Program of China(2018YFA0107601,2018YFC1004000 and 2017YFA0102702).
Proper development of fetal germ cells(FGCs)is vital for the precise transmission of genetic and epigenetic information through generations.The transcriptional landscapes of human FGC development have been revealed;ho...
supported by the National Natural Science Foundation of China (81427801, 81827901);National Basic Research Program of China (2015CB352003);Science Fund for Creative Research Groups (61721092);Fundamental Research Funds for the Central Universities (2018KFYXKJC039);Director Fund of WNLO。
Resolution is undoubtedly the most important parameter in optical microscopy by providing an estimation on the maximum resolving power of a certain optical microscope. For centuries, the resolution of an optical micro...
This work was supported by grants to Songmin Ying from the Ministry of Science and Technology of China(2016YFA0100301);the National Natural Science Foundation of China(81870007,81920108001);the Zhejiang Provincial Natural Science Foundation(LD19H160001);the Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents(2016-63).
Common fragile sites(CFSs)are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes.They are hotspots for chromosome rearrangements and structural variations,which have been extensively implic...
Project supported by the National Natural Science Foundation of China(Grant Nos.11534008,11605126,and 11804271);the Fund from the Ministry of Science and Technology of China(Grant No.2016YFA0301404);the Natural Science Basic Research Plan in Shaanxi Province,China(Grant No.2017JQ1025);the Doctoral Fund of the Ministry of Education of China(Grant Nos.2016M592772 and 2018M631137);the Fundamental Research Funds for the Central Universities
In ghost imaging, an illumination light is split into test and reference beams which pass through two different optical systems respectively and an image is constructed with the second-order correlation between the tw...
financial support from China National Natural Science Foundation(61575031);National Key Basic Research and Development Program of China(Program 973)(2013CBA01700);Fundamental Research Funds for the Central Universities(106112016CDJXZ238826,106112016CDJZR125503);National Key Research and Development Program of China(2016YFED0125200,2016YFC0101100);financial support from the National Research Foundation,Prime Minister’s Office,Singapore under its Competitive Research Program(CRP award NRF-CRP15-2015-03).
The resolution of conventional optical elements and systems has long been perceived to satisfy the classic Rayleigh criterion.Paramount efforts have been made to develop different types of superresolution techniques t...
supported by the National Basic Research Program of China(Grant No.2015CB352002);the National Natural Science Foundation of China(Grant No.31770924,61827825,31600692,31470056);the Science Fund for Creative Research Group of China(Grant No.61721092);the Director Fund of the Wuhan National Laboratory for Optoelectronics.
Numerous commercial organic fluorophores with excellent optical properties are precluded from live-cell superresolution imaging due to poor cell permeability.Here,we develop a simple but effective strategy that render...