supported by the Notional Natural Science Foundation of China,Nos.81770918 (to ZLC),31871383 (to TL);the Natural Science Foundation of Zhejiang Province,No.LY16H120006 (to ZLC);the Departmental Funds from Wenzhou Medical University,No.89214018 (to ZLC)。
Slit-Robo GTPase-activating protein 2(SRGAP2) plays important roles in axon guidance, neuronal migration, synapse formation, and nerve regeneration. However, the role of SRGAP2 in neuroretinal degenerative disease rem...
supported by the Ministry of Higher Education,Government of Malaysia,No.FRGS/2/2014/SG03/UITM/02/2 UiTM IRMI file No.600-RMI/FRGS 5/3(111/2014),toⅡ;Yayasan Penyelidikan Otak,Minda dan Neurosains Malaysia(YPOMNM),No.YPOMNM/2019-04(2)UiTM IRMI No.100-IRMI/PRI 16/6/2(010/2019),to MAML。
Amyloid-beta(Aβ)-related alterations,similar to those found in the brains of patients with Alzheimer's disease,have been observed in the retina of patients with glaucoma.Decreased levels of brain-derived neurotrophic...
supported by National Natural Science Foundation of China(31600839 to BP);Guangdong Innovative and Entrepreneurial Research Team Program(2013S046 to BP);Shenzhen Peacock Plan(to BP)
Microglial cells(or microglia)are the mononuclear phagocytes residing in the central nervous system(CNS).In homeostasis,they showed ramified morphology with relative small cell bodies and long processes(Figure 1A...
Grant from the"Fondazione Giuseppe Levi–Accademia Nazionale dei Lincei"for the research project entitled:"Produzione extramitocondriale di ATP in mielina:localizzazione dei complessi della catena respiratoria e possible ruolo nella degenerazione assonale in Sclerosi Multipla",No.Borsa"Giuseppe Levi"_2013;the‘‘Compagnia di San Paolo’’-Neuroscience Program,for the research project entitled:‘‘Energetic metabolism in myelinated axon:a new trophic role of myelin sheath’’,No.2008.1142
More than any other organs,brain energy demand is entirely dependent on glucose catabolism through the oxidative phosphorylation(OXPHOS).Glucose is the major cerebral energy substrate in the nervous system(NS).Ket...
supported by Spanish Ministry of Economy and Competitiveness:SAF-2012-38328;ISCIII-FEDER"Una manera de hacer Europa"PI13/01266,PI13/00643,RETICS:RD12/0034/0014
Retinal ganglion cells(RGCs)are located in the innermost layer of the retina and are the only retinal output neurons,conveying light information to the main retinorecipient target regions of the brain responsible fo...