RIBONUCLEOPROTEIN

作品数：18被引量：14H指数：2
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相关领域：生物学医药卫生更多>>
相关机构：山西大学南开大学更多>>
相关期刊：《Journal of Animal Science and Biotechnology》《Science China(Life Sciences)》《World Journal of Gastroenterology》《Journal of Microbiology and Immunology》更多>>
相关基金：国家自然科学基金更多>>
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Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway
《World Journal of Gastrointestinal Oncology》2024年第5期2038-2059,共22页Xiang-Hui Wan Guo-Bing Jin Qun Yang Ji-Long Hu Zhi-Liang Liu Jun Rao Can Wen Peng-Ling Li Xi-Mei Yang Bo Huang Xiao-Zhong Wang 
Supported by the National Natural Science Foundation of China,No.82160405;Jiangxi Provincial Natural Science Foundation,No.20232BAB206131,No.20212ACB206016,and No.20224BAB206114;Jiangxi Provincial Health Commission Project,No.202310887;the Development Fund of Jiangxi Cancer Hospital,No.2021J10.
BACKGROUND Heterogeneous ribonucleoprotein A1(hnRNPA1)has been reported to enhance the Warburg effect and promote colon cancer(CC)cell proliferation,but the role and mechanism of the miR-490-3p/hnRNPA1-b/PKM2 axis in ...
关键词：Heterogeneous ribonucleoprotein A1-b MiR-490-3p Colon cancer Alternative splicing Warburg effect 
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein(RNP)to inhibit herpes simplex virus1 infection in vitro and in vivo
《Acta Pharmaceutica Sinica B》2024年第3期1362-1379,共18页Yuanda Wan Liren Li Ruilin Chen Jiajia Han Qiyun Lei Zhipeng Chen Xiaodong Tang Wenyu Wu Shuwen Liu Xingang Yao 
supported by the Guangdong Basic and Applied Basic Research Foundation(2023A1515030057,Xingang Yao);the National Natural Science Foundation of China(82373873,Xingang Yao)。
Extracellular vesicles(EVs)have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins(RNPs),owing to their ability to minimize off-target effects and immune responses.However,enhancement...
关键词：Extracellular vesicles CRISPR/Cas9 RIBONUCLEOPROTEINS PTGFRN Fc/Spa HSV1 Neuron-targeting Delivery 
Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation被引量：1
《Journal of Animal Science and Biotechnology》2024年第1期456-462,共7页Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-Koo Yi Jae-Jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae Son Soo-Young Yum Won-Wu Lee Goo Jang 
financially supported by the National Research Foundation of Korea(NRF-2021R1A5A1033157 for SRC program:382 Comparative medicine Disease Research Center,NRF-2021R1F1A105195313);the Research Institute of Veterinary Science,the BK21 Four for Future Veterinary Medicine Leading Education and Research Center,and a Seoul National University(SNU)grant(#550e2020005)。
Background Genome editing has been considered as powerful tool in agricultural fields.However,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestat...
关键词：BETA-LACTOGLOBULIN CATTLE CRISPR-Cas9 ELECTROPORATION KNOCKOUT MSTN PRNP 
Deciphering molecular mechanisms of phase separation in RNA biology by single-molecule biophysical technologies
《Acta Biochimica et Biophysica Sinica》2023年第7期1034-1041,共8页Yuchen Li Mengmeng Xu Zhi Qi 
supported by the grants from the National Natural Science Foundation of China(Nos.T2225009 to Z.Q.and 32088101).
Ribonucleic acid(RNA)biology has emerged as one of the most important areas in modern biology and biomedicine.RNA and RNA-binding proteins(RBPs)are involved in forming biomolecular condensates,which are crucial for RN...
关键词：single-molecule biophysical technologies liquid-liquid phase separation(LLPS) ribonucleoprotein(RNP)granule 
A candidate protective factor in amyotrophic lateral sclerosis:heterogenous nuclear ribonucleoprotein G被引量：2
《Neural Regeneration Research》2023年第7期1527-1534,共8页Fang Yang Wen-Zhi Chen Shi-Shi Jiang Xiao-Hua Wang Ren-Shi Xu 
supported by the National Natural Science Foundation of China,Nos.30560042,81160161,81360198,82160255;Education Department of Jiangxi Province,Nos.GJJ13198 and GJJ170021;Jiangxi Provincial Department of Science and Technology,Nos.[2014]-47,20142BBG70062,20171BAB215022,20192BAB205043;Health and Family Planning Commission of Jiangxi Province,No.20181019(all to RSX).
Heterogenous nuclear ribonucleoprotein G is down-regulated in the spinal cord of the Tg(SOD1*G93A)1Gur(TG)amyotrophic lateral sclerosis mouse model.However,most studies have only examined heterogenous nuclear ribonucl...
关键词：amyotrophic lateral sclerosis Bax heterogenous nuclear ribonucleoprotein G heterogenous nuclear ribonucleoprotein G-siRNA neuron death superoxide dismutase 1 TAR DNA binding protein 43 TG(SOD1*G93A)1Gur mice 
Fragile X Messenger Ribonucleoprotein 1(FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice
《Bone Research》2023年第2期384-397,共14页Padmini Deosthale Julián Balanta-Melo Amy Creecy Chongshan Liu Alejandro Marcial Laura Morales Julita Cridlin Sylvia Robertson Chiebuka Okpara David J.Sanchez Mahdi Ayoubi Joaquín N.Lugo Christopher J.Hernandez Joseph M.Wallace Lilian I.Plotkin 
supported by the National Institutes of Health R01-AR053643;Veterans Research Administration Merit Award I01BX00515;a Research Support Funds Grant(RSFG),Indiana University Purdue University Indianapolis-Office of the Vice Chancellor for Research,Indianapolis to LIP.;supported by ASBMR Fund for Research and Education Research and Collaborative Grant Program;supported by the National Institutes of Health R01AG067997 to CJH;supported by the IUPUI Diversity Scholars Research Program(DSRP);Diversity Summer Undergraduate Research Opportunity Program(DS-UROP);Indiana CTSI Student Summer Research Program;IUPUI work study program;supported by the Life Health Science Internship(LHSI)。
Fragile X Messenger Ribonucleoprotein 1(FMR1)gene mutations lead to fragile X syndrome,cognitive disorders,and,in some individuals,scoliosis and craniofacial abnormalities.Four-month-old(mo)male mice with deletion of ...
关键词：female MESSENGER AGILE 
Efficient genome editing in Claviceps purpurea using a CRISPR/Cas9 ribonucleoprotein method被引量：3
《Synthetic and Systems Biotechnology》2022年第2期664-670,共7页Lu Yu Meili Xiao Zhihua Zhu Yinmei Wang Zhihua Zhou Pingping Wang Gen Zou 
This work was financially supported by the National Key Research and Development Program of China(Grant No.2018YFA0900500);the National Natural Science Foundation of China(Nos.31921006,31470201,and,31741003);the Strategic Biological Resources Service Network Plan of the Chinese Academy of Sciences(Grant No.KFJ-BRP-009).
Claviceps purpurea produces many pharmacologically important ergot alkaloids(EAS),which are widely used to treat migraine and hypertension and to aid childbirth.Although an EAS biosynthetic cluster of C.purpurea has b...
关键词：RIBONUCLEOPROTEIN Genome editing Ergot alkaloids Biosynthetic pathway Homologous recombination 
CRISPR ribonucleoprotein-mediated genetic engineering in plants被引量：5
《Plant Communications》2021年第2期38-50,共13页Yingxiao Zhang Brian Iaffaldano Yiping Qi 
supported by the National Science Foundation Plant Genome Research Program(award nos.IOS-1758745 and IOS-2029889);the U.S.Department of Agriculture Biotechnology Risk Assessment Grant Program(award nos.2018-33522-28789 and 2020-33522-32274);the Emergency Citrus Disease Research and Extension Program(award no.2020-70029-33161);a Foundation for Food and Agriculture Research grant(award no.593603)and Syngenta。
CRISPR-derived biotechnologies have revolutionized the genetic engineering field and have been widely applied in basic plant research and crop improvement.Commonly used Agrobacterium-or particle bombardment-mediated t...
关键词：CRISPR RNP genetic engineering genome editing transgene free 
Enhanced Bombyx genome editing via Cas9 ribonucleoprotein injection被引量：1
《Insect Science》2019年第6期1059-1062,共4页Ling Jia San-Yuan Ma Tong Zhang Wei-Qing Xing Yue Liu Yu-Feng Li Xiao-Xu Chen Qing-You Xia 
the National Natural Science Foundation of China(No.31530071);the Chongqing Postdoctoral Science Foundation (No. Xm2016030);Chongqing Research program of basic Research and Frontier Technology(No.cstc2017jcyjAX0349).
Dear Editor, The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) system has become a popular and powerful method for manipulating genomes with considerably little eff...
关键词：Bombyx GENOME RIBONUCLEOPROTEIN INCREASING CONCERNS 
Gene Expression Changes Associated with the Loss of Heterogeneous Nuclear Ribonucleoprotein M Function
《American Journal of Molecular Biology》2017年第2期87-98,共12页Jun-ichi Takino Kentaro Nagamine Mikoto Suzuki Akiko Sakasai-Sakai Masayoshi Takeuchi Takamitsu Hori 
Advanced glycation endproducts (AGEs) are formed by the nonenzymatic reaction of sugars with proteins. Glycation may adversely affect proteins, such as by inducing a loss of function. It has been shown that glyceralde...
关键词：Glycation NONALCOHOLIC STEATOHEPATITIS Heterogeneous NUCLEAR RIBONUCLEOPROTEIN M Biomarkers 
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