云南高校图书馆联盟文献共享服务平台- ROX

ROX: 作品数：279被引量：609H指数：11; 导出分析报告; 相关领域：理学医药卫生更多>>; 相关作者：李波潘崚张学军董作仁牛志云更多>>; 相关机构：中国科学院北京大学沈阳化工大学南京师范大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金国家高技术研究发展计划更多>>

Effect of cholesterol metabolism on hepatolithiasis: 《World Journal of Gastroenterology》2025年第1期157-162,共6页Lin Zheng Zi-Yu Ye Jun-Ji Ma; Supported by Hebei Natural Science Foundation,No.H2022206539;Hebei Provincial Government Funded Clinical Talents Training Project,No.ZF2023143.; Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after surgery.Cholesterol metabolism seems to play an impo...; 关键词：HEPATOLITHIASIS Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

Facile fabrication of NiCo-hydroxysulfide nanosheets array for electrocatalytic urea oxidation: 《Science China(Technological Sciences)》2025年第1期218-228,共11页Jing ZOU Chang LIU Kun XIANG Qiong LI Shihao DAI Jizhou JIANG; supported by the National Natural Science Foundation of China(Grant No.62004143);the Key R&D Program of Hubei Province(Grant No.2022BAA084);the Natural Science Foundation of Hubei Province(Grant No.2021CFB133);the National Key R&D Program of China(Grant No.2022YFC3902703);the Innovation Project of Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education(Grant Nos.LCX2021003,LCX202304);the Scientific Research Foundation of Wuhan Institute of Technology(Grant No.K202253);the Open Research Fund of Key Laboratory of Material Chemistry for Energy Conversion and Storage(HUST),Ministry of Education(Grant No.2021JYBKF05);the 14th Graduate Education Innovation Fund of Wuhan Institute of Technology(Grant Nos.CX2022462,CX2023141)。; Urea oxidation reaction(UOR)instead of anodic oxygen evolution reaction(OER)is considered an effective way to reduce energy consumption in electrocatalytic water splitting for hydrogen production.Nevertheless,the slow...; 关键词：urea oxidation reaction NiCo-hydroxysulfide electrocatalyst hydrogen

Synchronized lineage tracing of cell membranes and nuclei by dual recombinases and dual fluorescent: 《Journal of Genetics and Genomics》2024年第12期1474-1484,共11页Xueying Yang Shun He Xufeng Li Zhihou Guo Haichang Wang Zhuonan Zhang Xin Song Ke Jia Lingjuan He Bin Zhou; supported by the National Key Research&Development Program of China(2021YFA0805100,2023YFA1800700,2019YFA0110403,2019YFA0802000);the National Science Foundation of China(82088101,32370885,92368103,32370897);the Westlake Education Foundation,and the Benyuan Charity Fund,Research Funds of Hangzhou Institute for Advanced Study(2022ZZ01015 and B04006C01600515)。; Genetic lineage tracing has been widely employed to investigate cell lineages and fate.However,conventional reporting systems often label the entire cytoplasm,making it challenging to discern cell boundaries.Additiona...; 关键词：Lineage tracing Dual recombinases system CRE-LOXP Dre-rox Cell membrane and nucleus labeling ProTracer system

2-hydroxy-3-methyl anthraquinone promotes apoptosis and inhibits invasion of human hepatocellular carcinoma cells by targeting nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin-1/cellular tumor antigen p53 signaling pathway: 《Journal of Traditional Chinese Medicine》2024年第6期1104-1110,共7页WU Shuang LI Qiao ZHU Xieying ZHANG Taoyuan; Natural Science Basic Research Plan in Shannxi Province of China,the Intervention and Mechanism of Developmentalendotheliallocus-1 Regulating Macrophage Efferocytosis on Airway Inflammation in Chronic Obstructive Pulmonary Disease (No. 2020JQ-543);the Function and Mechanism of New Tumor Suppressor TSC22D2 in Cancer Glycometabolism (No. 2020JQ-927);Fundamental Research Funds for The Central University:the Role of TSC22D2-centered Protein Interaction Map in Cancer Glycometabolism and Cell Growth (No. xzy012019129)。; OBJECTIVE: To investigate the anti-liver cancer effect of 2-hydroxy-3-methyl anthraquinone(HMA) and the specific mechanism based on nicotinamide adenine dinucleotidedependent protein deacetylase sirtuin-1(SIRT1)/cellu...; 关键词：2-hydroxy-3-methylanthraquinone carcinoma hepatocellular apoptosis INVASION sirtuin 1 genes p53

Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia: 《Food Science and Human Wellness》2024年第6期3083-3094,共12页Guillermo Santos-Sánchez Ana IsabelÁlvarez-López Eduardo Ponce-España Patricia Judith Lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro; funded by Consejería de Salud, Junta de Andalucía (PC-0111-2016-0111);PEMP-0085-2020 (cofinanciado con fondos FEDER, convocatoria Resolución de 7 de julio de 2021 de la Secretaría General de Investigación, Desarrollo e Innovación en Salud, que convoca subvenciones para financiar la investigación, el desarrollo y la innovación en Biomedicina y Ciencias de la Salud en Andalucía, para 2021);the Programa PAIDI from the Junta de Andalucía (CTS160);supported by a FPU grant from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/02339);supported by the VI Program of Inner Initiative for Research and Transfer of the University of Seville (VIPPIT2020-II.4);by a postdoctoral fellowship from the Andalusian Government Ministry of Economy, Knowledge, Business, and University (DOC_00587/2020);funded by Andalusian Government Ministry of Health (PI-0136-2019);supported by the VI Program of Inner Initiative for Research and Transfer of University of Seville; Cardiovascular diseases(CVDs)are the leading global cause of mortality and disease burden.Statins are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent CVDs.The biochemical mechanism o...; 关键词：Functional foods Cholesterol Cardiovascular diseases STATINS 3-Hydroxy-3-methylglutaryl-coenzyme A

遗传谱系示踪技术与组织再生研究: 《中国细胞生物学学报》2024年第11期1869-1880,共12页何顺何灵娟; 国家自然科学基金(批准号:323B2028、32370885、92368103)资助的课题。; 遗传谱系示踪技术已经成为揭示细胞起源和细胞命运决定的重要工具。近年来,该领域取得了较大的进展,研究者们已经成功构建并优化了一系列新型遗传谱系示踪技术,例如双同源重组酶介导的遗传谱系示踪技术。这些新兴技术为深入研究组织再...; 关键词：遗传谱系示踪 Dre-rox CRE-LOXP 组织再生肝脏再生

Discovery of an enantiopure N-[2-hydroxy-3-phenyl piperazine propyl]-aromatic carboxamide derivative as highly selectiveα_(1D/1A)-adrenoceptor antagonist and homology modelling: 《Chinese Chemical Letters》2024年第11期435-441,共7页Junjun Huang Ran Chen Yajian Huang Hang Zhang Anran Zheng Qing Xiao Dan Wu Ruxia Duan Zhi Zhou Fei He Wei Yi; supported by Natural Science Foundation of Guangdong Province(Nos.2021A1515010101,2021A1515011372,2023A1515011895);National Natural Science Foundation of China(Nos.21807017,82273759,32371529);Guangzhou Medical University Scientific Research Capacity Improvement Project(No.02-410-2405104)。; α_(1)-Adrenergic receptor(AR)blockers can be effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms(BPH/LUTS),their usage is limited by cardiovascular-related side effects that are c...; 关键词：Benign prostatic hyperplasia α_(1)-AR antagonist Phenylpiperazine Homology modelling Subtype selectivity

ROX-HR指数联合血浆BNP水平对脓毒症休克液体复苏效果的预测价值: 《转化医学杂志》2024年第5期705-709,共5页吴飞时素琴王玉荣; 扬州市-扬州大学市校合作共建创新平台,扬州市大数据分析与知识服务重点实验室开发课题(YBK202208)。; 目的探讨呼吸频率–氧合–心率(ROX-HR)指数联合血浆脑钠肽(BNP)水平对脓毒症休克液体复苏效果的预测价值。方法选取2023年1月至2024年1月扬州大学附属医院院收治的135例脓毒症休克患者作为研究对象,所有患者均接受液体复苏治疗,治疗前...; 关键词：脓毒症休克液体复苏呼吸频率–氧合–心率脑钠肽

Regulatory Mechanism of Xiaozheng Tongluo Method on Hepatic Lipid Metabolism in ApoE^(-/-) Mice:Insights from the Sterol Regulatory Element-binding Protein-2/3-hydroxy-3-methylglutaryl Coenzyme A Reductase/Low-density Lipoprotein Receptor Signaling Pathwa: 《World Journal of Traditional Chinese Medicine》2024年第3期363-369,共7页Xin Zhang Jian-Li Ge Kun Su Jian-Ming He Min-Mei Zhang Jing Zhang Yun-Long Ma Yun-Chao Sun Xin-Qiang Chu; supported by the Science and Technology Support Program Project of the Hebei Provincial Department of Science and Technology (No. 19277753D);the Scientific Research Project of the Hebei Administration of TCM (No. 2019004, No. 2019066); Objective: The objective of the study was to explore the regulatory mechanism of the Xiaozheng Tongluo method on lipid metabolism in liver tissue based on the sterol regulatory element-binding protein-2/(SREBP2)/3-hyd...; 关键词：ApoE^(‑/‑)mice lipid metabolism liver sterol regulatory element‑binding protein‑2/3‑hydroxy‑3‑methylglutaryl coenzyme a reductase/low‑density lipoprotein receptor signaling pathway Xiaozheng Tongluo method

Assessment of the piroxicam-incited model of synchronized colitis in T-cell receptor alpha chain-deficient mice: 《Animal Models and Experimental Medicine》2024年第4期533-543,共11页Maximo E.Lange Danisa M.Bescucci Valerie F.Boras Tony Montina G.Douglas Inglis; Alberta Innovates,Grant/Award Number:CD-60;Canadian Glycomics Network,Grant/Award Number:CD-50;Agriculture and Agri-Food Canada,Grant/Award Number:2991。; Background:A multitude of mouse models are utilized to emulate and study intestinal inflammation.T-cell receptor alpha chain(TCRα)-deficient mice are used as a model of spontaneous colitis that has similarities with ...; 关键词：COLON DEXAMETHASONE HISTOLOGY induction inflammation KNOCKOUT

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