supported by Suzhou Basic Research Key Project(No.SKY2023009),Suzhou health youth backbone talent“national tutorial system”training project(Qngg2023005);Beijing Xisike Clinical Oncology Research Foundation(Y-tongshu2021/qn-0366).
P90 Ribosomal S6 Kinases(RSKs)constitute a class of Serine/Threonine(Ser/Thr)protein kinases and play a critical role as downstream targets in the Raf/MEK/ERK signaling pathway.Gaining insight into the biological func...
Aim: To observe the rats’ learning and memory acquisition ability disturbance induced by BI-D1870. Methods: Male SD rats were randomly divided into control group, solvent control group and BI-D1870 group. The rats in...
National Natural Science Foundation of China (No.81273546);Shanghai Science and Technology Committee (No. 14DZ2294100).
BRAF and MEK inhibitors have shown remarkable clinical efficacy in BRAF-mutant melanoma;however, most patients develop resistance, which limits the clinical benefit of these agents. In this study, we found that the hu...