This work was supported by the Outstanding Youth Innova-tion Team of University in Shandong Province(2019KJC019);the Key Research and Development(Public Welfare)Project of Shandong Province(2019GSF107023);the National Natural Science Foundation of China(21775090,41807484,41977345,42077363);the Natural Science Foundation of Shandong Provinee of China(ZR2018MB028).
As a key epigenetic modification,5-formylcytosine(5fC)controls many important cell functions,such as gene expression and cell differentiation.However,5fC exists in mammalian tissues and cells with low content,and its ...