SEQUENCING

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Spatially resolved transcriptomics:advances and applications被引量：1
《Blood Science》2023年第1期1-14,共14页Honglin Duan Tao Cheng Hui Cheng 
the Ministry of Science and Technology of China(2021YFA1100900 and 2020YFE0203000);the National Natural Science Foundation of China(81730006,81922002,81861148029,and 81870086);CAMS Innovation Fund for Medical Sciences(2021-I2M-1-040 and 2021-I2M-1-019);Haihe Laboratory of Cell Ecosystem Innovation Fund(HH22KYZX0016);Distinguished Young Scholars of Tianjin(19JCJQJC63400).
Spatial transcriptomics,which is capable of both measuring all gene activity in a tissue sample and mapping where this activity occurs,is vastly improving our understanding of biological processes and disease.The fiel...
关键词：In situ hybridization In situ sequencing Spatially resolved multi-omics Spatially resolved transcriptomics 
Accurate quantification of 3'-terminal 2'-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR被引量：2
《Frontiers of Medicine》2022年第2期240-250,共11页Yan Kong Huanhuan Hu Yangyang Shan Zhen Zhou Ke Zen Yulu Sun Rong Yang Zheng Fu Xi Chen 
This work was supported by the Fundamental Research Funds for the Central Universities(No.020814380146);National Basic Research Program of China(973 Program)(No.2014CB542300);National Natural Science Foundation of China(Nos.32022015,32001077,31871295,21877060,81250044,81602697,and 81772727);Research Unit of Extracellular Non-Coding RNA,Chinese Academy of Medical Sciences(No.2021RU015).
The continuing discoveries of novel classes of RNA modifications in various organisms have raised the need for improving sensitive,convenient,and reliable methods for quantifying RNA modifications.In particular,a subs...
关键词：small RNAs 2'-0-methylation SEQUENCING RT-QPCR 
Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China被引量：10
《Journal of Genetics and Genomics》2022年第1期13-19,共7页Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li 
partially supported by grants from the Ministry of Science and Technology of China(2016YFC1000306);the Beijing Municipal Science and Technology Commission Foundation(Z181100001918003);the Beijing Municipal Commission of Health and Family Planning Foundation(2018-21141,2020-4-1144);Beihang University&Capital Medical University Advanced Innovation Center for Big Data-Based Precision Medicine Plan(BHME-201905)。
Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 46...
关键词：Newborn screening Next-generation sequencing Targeted sequencing Monogenic disorders Clinical practice 
The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks被引量：3
《Zoological Research》2021年第6期834-844,共11页Min-Sheng Peng Jian-Bo Li Zheng-Fei Cai Hang Liu Xiaolu Tang Ruochen Ying Jia-Nan Zhang Jia-Jun Tao Ting-Ting Yin Tao Zhang Jing-Yang Hu Ru-Nian Wu Zhong-Yin Zhou Zhi-Gang Zhang Li Yu Yong-Gang Yao Zheng-Li Shi Xue-Mei Lu Jian Lu Ya-Ping Zhang 
This work was supported by the National Key Research and Development Projects of the Ministry of Science and Technology of China,National Key Research and Development Program of China(2021YFC0863300);Ministry of Agriculture of China(2016ZX08009003-006);Key Program of Chinese Academy of Sciences(KJZD-SW-L11);Animal Branch of the Germplasm Bank of Wild Species,Chinese Academy of Sciences(the Large Research Infrastructure Funding)。
Understanding the zoonotic origin and evolution history of SARS-CoV-2 will provide critical insights for alerting and preventing future outbreaks.A significant gap remains for the possible role of pangolins as a reser...
关键词：SARS-CoV-2 PANGOLIN Recombination DIVERSITY SEQUENCING MTDNA 
Establishment of transposase-assisted low-input m^(6)A sequencing technique被引量：2
《Journal of Genetics and Genomics》2021年第11期1036-1039,共4页Tao Chen Yan Li Dong-Zhao Ma Zhang Zhang Jian-Fei Xi Guan-Zheng Luo 
the Ministry of Science and Technology of China(National Science and Technology Major Project,2019YFA0802203,2018YFA0109100);National Natural Science Foundation of China(31922015,31870808,91753129);Natural Science Foundation of Guangdong Province(2018B030306044,2019A1515110099);China Postdoctoral Science Foundation(2020M672949 and 2019M653164).
RNA modification has been recognized as a pivotal regulator that affects gene expression in a post-transcriptional manner.To date,more than 150 distinct types of RNA modification have been identi-fied,among which N6-m...
关键词：acute SUPPRESSOR 
Mapping the epigenetic modifications of DNA and RNA被引量：26
《Protein & Cell》2020年第11期792-808,共17页Lin-Yong Zhao Jinghui Song Yibin Liu Chun-Xiao Song Chengqi Yi 
This work was supported by the National Natural Science Foundation of China(Grant No.31861143026 to C.Y.);the Ministry of Science and Technology of China(Grant Nos.2019YFA0110902 and 2019YFA08002501 to C.Y.);the Ludwig Institute for Cancer Research(C-X.S.),Cancer Research UK(C63763/A26394 and C63763/A27122 to C-X.S.)NIHR Oxford Biomedical Research Centre(to C-X.S.)and Emerson Collective(to C-X.S.).L-Y.Z.is supported by China Scholarship Council.The views expressed are those of the authors and not necessarily those of the NHS,the NIHR or the Department of Health.We apologize for not being able to cite all the publications related to this topic due to space constraints of the journal.
Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,respectively.The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edge...
关键词：DNA modification DNA methylation RNA modification epitranscriptomics EPIGENETICS long read sequencing 
DNA storage:research landscape and future prospects被引量：22
《National Science Review》2020年第6期1092-1107,共16页Yiming Dong Fajia Sun Zhi Ping Qi Ouyang Long Qian 
This work was supported by the National Natural Science Foundation of China(11434001 and 11774011 to Q.O.,31901063 to Q.L.);the Ministry of Science and Technology of China(2012AA02A702 to Q.O.),the Guangdong Provincial Academician Workstation of BGI SyntheticGenomics(2017B090904014).
The global demand for data storage is currently outpacing the world’s storage capabilities.DNA,the carrier of natural genetic information,offers a stable,resource-and energy-efficient and sustainable data storage sol...
关键词：DNA storage INFORMATION COMPILATION SEQUENCING 
Identification of microRNA-like RNAs in Ophiocordyceps sinensis被引量：6
《Science China(Life Sciences)》2019年第3期349-356,共8页Wen Zhang Xiaona Li Lina Ma Uzair Urrehman Xilinqiqige Bao Yujing Zhang Chen-Yu Zhang Dongxia Hou Zhen Zhou 
supported by the National Basic Research Program of China (2014CB542300);the National Natural Science Foundation of China (81602697);the Natural Science Foundation of Jiangsu Province (BE2016737); the Fundamental Research Funds for the Central Universities (020814380070)
Ophiocordyceps sinensis is well known as a traditional Chinese medicine and has widely been used for over 2,000 years to stimulate immune system, decrease blood pressure and to inhibit tumor growth. While miRNAs are i...
关键词：Ophiocordyceps SINENSIS O.sinensis miRNA milRNA HIGH-THROUGHPUT SEQUENCING 
A targeted sequencing approach to find novel pathogenic genes associated with sporadic aortic dissection被引量：5
《Science China(Life Sciences)》2018年第12期1545-1553,共9页Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang 
supported by National Natural Science Foundation of China (81700413);National Key Basic Research Program of China (2012CB518004, 2012CB517801)
Aortic dissection(AD) is a heterogeneous genetic disease of the aorta with high mortality and poor prognosis. However, only few genetic causes of AD have been explored till date. After conducting a broad literature re...
关键词：AORTIC DISSECTION next-generation SEQUENCING genetic diagnosis 
Genetic Analysis of the PKHD1 Gene with Long-rang PCR Sequencing
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2016年第5期758-766,共9页童永清 刘蓓 付朝泓 郑红云 顾剑 刘航 罗洪波 李艳 
supported by grants from the Hubei Provincial Natural Science Foundation of China(No.2010CDB-06903);National Key Basic Research Program of China(“973”Program,No.2012CB526706);the National Natural Science Foundation of China(Nos.81000771 and 81271694)
PKHD1 gene mutations are found responsible for autosomal recessive polycystic kidney disease（ARPKD）. However, it is inconvenient to detect the mutations by common polymerase chain reaction（PCR） because the open re...
关键词：sequencing Sequencing recessive screening detecting conclusion applicable mutation genomic digestion 
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