financially supported by National Natural Science Foundation of China(Nos.32471396,82230071,82172098);Integrated Project of Major Research Plan of National Natural Science Foundation of China(No.92249303);Shanghai Committee of Science and Technology(No.23141900600,Laboratory Animal Research Project);Shanghai Clinical Research Plan(No.SHDC2023CRT01);Shanghai Municipal Demonstration Project for Innovative Medical Device Applications(No.23SHS05700);Young Elite Scientist Sponsorship Program by China Association for Science and Technology(No.YESS20230049).
The skeletal system,composed of bones,muscles,joints,ligaments,and tendons,serves as the foundation for maintaining human posture,mobility,and overall biomechanical functionality.However,with ageing,chronic overuse,an...
Little is known about the relationship between bone and brain;however,accumulated clinical and experimental evidence suggests that there is crosstalk and a bilateral dependence between the two organs.1 A recent review...
This work was supported in part by National Key R&D Program of China,No.2020YFA0112900(to RX);National Natural Science Foundation of China,Nos.81972034,92068104(to RX),82002262(to NL);Natural Science Foundation of Fujian Province,No.2022J06003(to RX).
Tissue-resident stem cells are a group of stem cells distinguished by their capacity for self-renewal and multilineage differentiation capability with tissue specificity.Among these tissue-resident stem cells,skeletal...
This work was supported in part by the Fulbright-Nehru Postdoctoral Research Fellowship,United States-India Educational Foundation,the Biosystem and Biomaterials Division,National Institute of Standards and Technology,Department of Commerce,and the Shobhit Institute of Engineering and Technology,Meerut,India(to DA),and by the Division of Intramural Research,National Institute of Dental and Craniofacial Research,a part of the Intramural Research Program,the National Institute of Health,Department of Health and Human Services(1ZIA DE000380 to PGR).
Based on studies over the last several decades,the self-renewing skeletal lineages derived from bone marrow stroma could be an ideal source for skeletal tissue engineering.However,the markers for osteogenic precursors...
I wish to thank the Nuffield Department of Clinical Laboratory Sciences,Radcliffe Department of Medicine,University of Oxford,Oxford,UK,and the Faculty of Health and Medical Sciences,University of Adelaide,and South Australian Health and Medical Research Institute,Adelaide,Australia,for their support.
Haematopoietic microenvironmental niches have been described as the‘gatekeepers’for the blood and immune systems.These niches change during ontogeny,with the bone marrow becoming the predominant site of haematopoies...