Polycomb group genes play crucial roles in the maintenance of the transcriptionally silenced state of genes for proper cell differentiation in animals and plants. While components of the polycomb repressive complex2 ...
Gonad development requires a coordinated soma-germline interaction that ensures renewal and differentiation of germline and somatic stem cells to ultimately produce mature gametes. The Drosophila tumour suppressor gen...
Transforming growth factor (TGF)-βs and their family members, including bone morphogenetic proteins (BMPs), Nodal and activins, have been implicated in the development and maintenance of various organs, in which ...
Only a small number of cells in adult tissues (the stem cells) possess the ability to self-renew at every cell division, while producing differentiating daughter cells to maintain tissue homeostasis for an organism...
supported by grants from the Major State Basic Research Development Program of China(No.001CB5099);the National High Technology Research and Development Program of China(No.2001AA216121);National Natural Science Foundation of China(No.30040003);Projects of Shanghai Science&Technology Development Foundation(No.99DJ14002,00DJ14033,01DJ14003);the Chinese Academy of Sciences(No.KSCX-2-3-08);Shanghai Municipal Education Commission and by Shanghai Second Medical University
To solve the problem of immune incompatibility, nuclear transplantation has been envisaged as a means to produce cells or tissues for human autologous transplantation. Here we have derived embryonic stem cells by the ...