STAT

作品数：591被引量：1569H指数：15
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Cisplatin ototoxicity involves cytokines and STAT6 signaling network被引量：3
《Cell Research》2011年第6期944-956,共13页Hyung-Jin Kim Gi-Su Oh Jeong-Han Lee Ah-Ra Lyu Hye-Min Ji Sang-Heon Lee Jeho Song Sung-Joo Park Yong-Ouk You Jeong-Dug Sul Channy Park Sang-Young Chung Sung-Kyun Moon David J Lim Hong-Seob So Raekil Park 
We herein investigated the role of the STAT signaling cascade in the production of pro-inflammatory cytokines and cisplatin ototoxicity. A significant hearing impairment caused by cisplatin injection was observed in B...
关键词：CISPLATIN OTOTOXICITY STAT INFLAMMATION apoptosis 
A switch from hBrm to Brgl at IFNy-activated sequences mediates the activation of human genes被引量：1
《Cell Research》2010年第12期1345-1360,共16页Yi Zhang Mo-bin Cheng Yan-jun Zhang Xin Zhong Hui Dai Li Yan Ning-hua Wu Ye Zhang Yu-fei Shen 
Acknowledgments We thank Drs XY Fu, CM Horvath, AN Imbalzano, HB Zhang, S Cadelwood and K Shuai for kindly providing plasmids, antibodies and chemicals used in this work. We thank Dr Robert A Casero, Jr of the Johns Hopkins University School of Medicine for his critical reading of the manuscript, and Dr Weimin Zhong of the Yale University for his contribution to the work. This work was supported by the National Natural Science Foundation of China （90408007, 30871382 and 30721063）, the National Basic Research Program of China （973 Program） （2005CB522405）, the National Key Scientific Program （2011CB964902） and Special Funds of State Key Laboratories （2060204）.
The SWI/SNF chromatin-remodeling complexes utilize energy from ATP hydrolysis to reposition nucleosomes and regulate the expression of human genes. Here, we studied the roles of human Brahma （hBrm） and Brahma-relate...
关键词：chromatin remodeling hBrm Brg 1 Stat 1 P300 HEAT-SHOCK IFNΓ 
Regulation of cytokine signaling pathways by PIAS proteins被引量：21
《Cell Research》2006年第2期196-202,共7页Ke Shuai 
Cytokines activate multiple signal transduction pathways to regulate gene expression. STATs and NF-kB are two important families of transcription factors activated by cytokines. Abnormal regulation of STAT and NF-kB a...
关键词：cytokine signaling gene regulation PIAS STAT NF-KB 
STAT3 in immune responses and inflammatory bowel diseases被引量：9
《Cell Research》2006年第2期214-219,共6页Xin Yuan Fu 
STAT3 has been known as a mediator for gene expression induced by many important cytokines. Recent studies have suggested that STAT3 has important functions in regulation of both innate and adaptive immunity. Loss of ...
关键词：STAT CYTOKINES innate and adaptive immunity INFLAMMATION Crohn＇s disease AUTOIMMUNITY 
Modulation of the activation of Statl by the interferon-gamma receptor complex
《Cell Research》2006年第1期113-123,共11页Christopher D Krause Wen He Sergei Kotenko Sidney Pestka 
The activation of Statl by the interferon-gamma （IFN-γ） receptor complex is responsible for the transcription of a significant portion of IFN-γ induced genes. Many of these genes are responsible for the induction ...
关键词：INTERFERON-GAMMA Stat 1 interferon-gamma receptor KINETICS electrophoretic mobility shift assay 
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