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作品数：203被引量：279H指数：8
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相关机构：爱尔眼科医院北京航空航天大学上海交通大学福建省农业科学院更多>>
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Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation被引量：20
《Cell Research》2017年第6期784-800,共17页Lian, Qiaoshi Xu, Jun Yan, Shanshan Huang, Min Ding, Honghua Sun, Xiaoyu Bi, Aiwei Ding, Jian Sun, Bing Geng, Meiyu 
Chemotherapies are known often to induce severe gastrointestinal tract toxicity but the underlying mechanism re- mains unclear. This study considers the widely applied cytotoxic agent irinotecan （CPT-11） as a repres...
关键词：DSDNA AIM2 EXOSOME INFLAMMASOME CHEMOTHERAPY intestinal toxicity 
Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres被引量：6
《Cell Research》2013年第5期705-719,共15页Peili Gu Wei Deng Ming Lei Sandy Chang 
Human single-strand （ss） DNA binding proteins 1 and 2 （hSSB1 and 2） are components of the hSSB1/2-INTS3- C9orf80 heterotrimeric protein complex shown to participate in DNA damage response and maintenance of genome...
关键词：TELOMERE DNA damage and repair cancer APOPTOSIS 
Human Stnl protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in被引量：4
《Cell Research》2012年第12期1681-1695,共15页Chenhui Huang Xueyu Dai Weihang Chai 
Telomere maintenance is critical for genome stability. The newly-identified Ctcl/Stnl/Tenl complex is important for telomere maintenance, though its precise role is unclear. We report here that depletion of hStnl indu...
关键词：Stnl telomere replication G-overhang polct 
A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand被引量：7
《Cell Research》2010年第4期408-420,共13页Dan Li Yang Dong Yu Jiang Huifeng Jiang Jing Cai Wen Wang 
Recent transcription profiling studies have revealed an unexpectedly large proportion of antisense transcripts in eukaryotic genomes. These antisense genes seem to regulate gene expression by interacting with sense ge...
关键词：de novo sense-antisense interaction mating pathway Saccharomyces cerevisiae 
Does ‘Immortal DNA strand＇ exist in ‘immortal＇ stem cells？
《Cell Research》2007年第10期834-835,共2页Linheng Li 
Stem cells function to generate differentiated cells, and, at the same time, are maintained as ‘immortal＇ cells through self-renewal. Accumulated evidence indicates that adult stem cells may be the most common precu...
关键词：干细胞 DNA 成熟细胞 细胞突变 
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