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Genome-wide DNA methylation landscape of four Chinese populations and epigenetic variation linked to Tibetan high-altitude adaptation
《Science China(Life Sciences)》2023年第10期2354-2369,共16页Zeshan Lin Yan Lu Guoliang Yu Huajing Teng Bao Wang Yajun Yang Qinglan Li Zhongsheng Sun Shuhua Xu Wen Wang Peng Tian 
the National Key Research and Development Program of China(2016YFC0900402);the Basic Science Center Program(32288101);the National Natural Science Foundation of China(32030020 and 31961130380);the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)。
DNA methylation(DNAm)is one of the major epigenetic mechanisms in humans and is important in diverse cellular processes.The variation of DNAm in the human population is related to both genetic and environmental factor...
关键词：DNA methylation double-strand bisulfite sequencing Chinese ethnic groups Tibetan high-altitude adaptation 
Shortening the sgRNA-DNA interface enables SpCas9 and eSpCas9(1.1)to nick the target DNA strand被引量：4
《Science China(Life Sciences)》2020年第11期1619-1630,共12页Rong Fan Zhuangzhuang Chai Sinian Xing Kunling Chen Fengti Qiu Tuanyao Chai Jin-Long Qiu Zhengbin Zhang Huawei Zhang Caixia Gao 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(Precision Seed Design and Breeding,XDA24020102);the National Transgenic Science and Technology Program(2018ZX0801002B);the National Natural Science Foundation of China(31788103 and 31971370);the Chinese Academy of Sciences(QYZDY-SSW-SMC030);the National Key R&D Program of China(2018YFA0900600,2016YFD0100102-11,and 2016YFD0100605)。
The length of the sgRNA-DNA complementary sequence is a key factor influencing the cleavage activity of Streptococcus pyogenes Cas9(SpCas9)and its variants.The detailed mechanism remains unknown.Here,based on in vitro...
关键词：SpCas9 eSpCas9(1.1) truncated spacer DSB nickase co-editing 
New cytosine base editor for plant genome editing被引量：2
《Science China(Life Sciences)》2018年第12期1602-1603,共2页Zhenxiang Li Xiangyu Xiong Jian-Feng Li 
A large number of beneficial agronomic traits in crops are associated with single nucleotide polymorphisms(SNPs)or point mutations(Jiao et al.,2010;Li et al.,2017;Ma et al.,2015).In the past,site-specific point mutati...
关键词：NEW CYTOSINE DNA double-strand 
Transcriptome analysis reveals long noncoding RNAs involved in fiber development in cotton (Gossypium arboreum)被引量：11
《Science China(Life Sciences)》2016年第2期164-171,共8页Changsong Zou Qiaolian Wang Cairui Lu Wencui Yang Youping Zhang Hailiang Cheng Xiaoxu Feng Mtawa Andrew Prosper Guoli Song 
the National Natural Science Foundation of China (31301369, 31271768, 31401425)
Long noncoding RNAs （lncRNAs） play important roles in various biological regulatory processes in yeast, mammals, and plants. However, no systematic identification of lncRNAs has been reported in Gossypium arboreum. ...
关键词：long noncoding RNAs strand specific RNA sequencing fiber TRANSCRIPTOME expression 
Role of ubiquitination in meiotic recombination repair被引量：4
《Science China(Life Sciences)》2010年第4期447-454,共8页CUI Li & LI Wei State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 
supported by grants to LI Wei from the Knowledge Innovation Program (Grant No. KSCX2-YW-N-071);the One Hundred Talents Program of Chinese Acad-emy of Sciences and the National Natural Science Foundation of China (Grant No. 30970603)
Programmed and unprogrammed double-strand breaks (DSBs) often arise from such physiological requirements as meiotic recombination, and exogenous insults, such as ionizing radiation (IR). Due to deleterious impacts on ...
关键词：UBIQUITIN MEIOSIS HOMOLOGOUS recombination DNA double-strand BREAKS 
Partial strands synthesizing leads to inevitable aborting and complicated products in consecutive polymerase chain reactions (PCRs)被引量：2
《Science China(Life Sciences)》2007年第4期548-556,共9页LUO Rui1,2 & ZHANG DaMing 1 State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049, China 
Supported by the National Natural Science Foundation of China (Grant No. 30430030)
Various abnormal phenomena have been observed during PCR so far. The present study performed a series of consecutive PCRs (including many rounds of re-amplification continuously) and found that the abortion of re-ampl...
关键词：consecutive PCR abnormal complicated product PARTIAL STRAND synthesis DISTURBING effect PCR-mediated recombination long distance PCR 
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