SUNITINIB

作品数：67被引量：190H指数：7
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相关机构：江苏省人民医院北京大学复旦大学附属肿瘤医院华中科技大学更多>>
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Circular RNA circAGAP1 promotes sunitinib sensitivity in renal cell carcinoma via sponging multiple PDGFR-targeted miRNAs
《Oncology Research》2025年第2期407-420,共14页QI LV GANGMIN WANG YI HONG TIANYI ZHU SHUANG QIN SAIFEI SUN YUTING WANG YAOHUA LIU QING ZHANG CHUNHUI MA PEIJUN WANG 
supported by Shanghai Natural Science Foundation(Grant Number 22ZR1456600);Science and Technology Innovation Action Plan in Shanghai on Experimental Animal Research(Grant Number 22140903600);Clinical Research and Cultivation Project of Tongji Hospital in Shanghai(Grant Number ITJ(QN)2201);the National Natural Science Foundation of China(Nos.82227807,81830059)。
Background:Sunitinib resistance is a major challenge in advanced renal cell carcinoma(RCC).Clinically,elucidating the underlying mechanisms and developing practical countermeasures for sunitinib resistance in RCC is d...
关键词：Renal cell carcinoma Sunitinib resistance Circular RNA circAGAP1 MiR-149-5p MiR-455-5p MiR-15a-5p 
Mechanisms of tyrosine kinase inhibitor resistance in renal cell carcinoma被引量：3
《Cancer Drug Resistance》2023年第4期858-873,共16页Patrick L.Sweeney Yash Suri Arnab Basu Vadim S.Koshkin Arpita Desai 
Renal cell carcinoma(RCC),the most prevalent type of kidney cancer,is a significant cause of cancer morbidity and mortality worldwide.Antiangiogenic tyrosine kinase inhibitors(TKls),in combination with immune checkpoi...
关键词：Antiangiogenic tyrosine kinase inhibitors renal cell carcinoma acquired resistance SUNITINIB tumor microenvironment immune checkpoint inhibitors 
Sunitinib-induced hyperammonemic encephalopathy in metastatic gastrointestinal stromal tumors:A case report
《World Journal of Clinical Cases》2023年第31期7629-7634,共6页Takaoki Hayakawa Shinsuke Funakoshi Yasuo Hamamoto Kenro Hirata Takanori Kanai 
BACKGROUND Sunitinib,a multi-targeted tyrosine kinase inhibitor(TKI),has been approved for the salvage treatment of gastrointestinal stromal tumors(GIST).Hyperammonemic encephalopathy is a rare but severe complication...
关键词：Tyrosine protein kinase inhibitors Sunitinib malate Hyperammonemic encephalopathy Gastrointestinal stromal tumors Case report 
A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance
《Journal of Pharmaceutical Analysis》2023年第5期514-522,共9页Ying-Qi Song Guo-Dong Li Dou Niu Feng Chen Shaozhen Jing Vincent Kam Wai Wong Wanhe Wang Chung-Hang Leung 
supported by the Science and Technology Development Fund(Grant Nos.:0007/2020/A1 and 0020/2022/A1);the State Key Laboratory of Quality Research in Chinese Medicine,University of Macao(Grant No.:SKL-QRCM(UM)-2020-2022);the University of Macao(Grant Nos.:MYRG2019-00002-ICMS and MYRG2020-00017-ICMS);2022 Internal Research Grant of SKLQRCM(University of Macao)(Grant No.:QRCM-IRG2022-011);the National Natural Science Foundation of China(Grant No.:22101230);the Natural Science Basic Research Program of Shaanxi(Grant No.:2021JQ-089);the Natural Science Foundation of Chongqing,China(Grant No.:cstc2021jcyj-msxmX0659).
Temozolomide(TMZ)is an anticancer agent used to treat glioblastoma,typically following radiation therapy and/or surgical resection.However,despite its effectiveness,at least 50%of patients do not respond to TMZ,which ...
关键词：Drug screening Alkyladenine DNA glycosylase N3-methyladenine GLIOBLASTOMA TEMOZOLOMIDE SUNITINIB 
ICG and Sunitinib-loaded NH_(2)-MOFs for Folate-mediated Hepatocellular Carcinoma Dual-modal Therapy被引量：1
《Chemical Research in Chinese Universities》2021年第4期967-974,共8页ZHANG Zhoujing LIU Chuang Ozioma AKAKURU XU Wenjing WU Aiguo ZHANG Yewei 
This work was supported by the Ningbo Natural Science Foundation,China(No.202003N4253);the Southeast University-China Pharmaceutical University Cooperative Research Project,China(No.2242019K3DZ06).
This research investigated a novel folic acid(FA)-modified zirconium core metal-organic framework(MOF)Uio-66 as a nanocarrier to deliver indocyanine green(ICG)and Sunitinib to cancer cells for combination therapy.Plat...
关键词：Metal organic framework Uio-66 Indocyanine green SUNITINIB Hepatocellular carcinoma 
胃肠道间质瘤Sunitinib耐药细胞株的建立及其生物学特性的研究被引量：3
《中国医师进修杂志》2020年第12期1057-1059,共3页王翠华 于学涛 姚新明 
上海市普陀区卫生系统自主创新科研资助项目(ptkwwS201719)。
目的:构建胃肠道间质瘤耐药细胞模型GIST882-Rs。方法:通过间歇浓度梯度倍增法针对胃肠道间质瘤细胞株GIST882进行体外诱导,使其对Sunitinib靶向药物耐药,研究构建耐药细胞模型GIST882-Rs。使用显微镜对细胞形态进行观察,通过流式细胞...
关键词：胃肠道间质瘤 细胞株 SUNITINIB 耐药 
Dopamine increases the anti-cancer efficacy of sunitinib in the treatment of pancreatic cancer被引量：1
《Journal of Chinese Pharmaceutical Sciences》2020年第10期689-700,共12页Junsheng Xue Siyuan Wang Fangran Hao Xiuyun Tian Hong Su Liang Yang Qiming An Chunyi Hao Tianyan Zhou 
National Natural Science Foundation of China(Grant No.81473277);Innovation Team of Ministry of Education(Grant No.BMU2017TD003)。
Sunitinib(SUN)is a multi-targeted receptor tyrosine kinase inhibitor(TKI)that may lead to drug resistance and metastasis because of increased cancer stem-like cells(CSCs)due to the induction of hypoxia.Our group has p...
关键词：SUNITINIB DOPAMINE Cancer stem-like cell Combination therapy Pancreatic cancer 
PK/PD modeling based on NO-ET homeostasis for improving management of sunitinib-induced hypertension in rats被引量：2
《Acta Pharmacologica Sinica》2020年第5期719-728,共10页Hao-chen Liu Xiao-ting Zhou Yun-si Zheng Hua He Xiao-quan Liu 
the National Natural Science Foundation of China(no.81773806 and no.81503145);“Double First-Class”University Project(no.CPU2018GY19);the Fundamental Research Funds for the Central Universities(no.2632018ZD10).
Sunitinib is an oral small molecule multitargeted tyrosine kinase inhibitor,which is currently used to treat severe cancers.Clinical research has shown that patients treated with sunitinib develop hypertension.As soon...
关键词：SUNITINIB HYPERTENSION blood pressurefluctuation PK/PD modeling simulation macitentan 
Berberine enhances the activity of Sunitinib by targeting telomere G-quadruplex被引量：2
《Journal of Chinese Pharmaceutical Sciences》2019年第5期289-297,共9页Haitao Hou Zibing Song Jieqin Ding Dengguo Wei Sheng Hu Qianqian Zhai Xiali Yue 
Huazhong Agricultural University Scientific&Technological Self-innovation Foundation(Grant No.2015RC013);The Fundamental Research Funds for the Central Universities(Grant No.2662017PY113,2662015PY208,2662015BQ048);National Natural Science Foundation of China(Grant No.21502060,21708011);Open fund of The State Key Laboratory of Bio-organic and Natural Products Chemistry,CAS(Grant No.SKLBNPC16343);Open fund of Beijing National Laboratory For Molecular Sciences
G-quadruplexes are stable secondary structures formed with guanine rich sequences,which are widely distributed in genome.Chemical compounds stabilizing G-quadruplexes exhibited inhibition on tumor cells.However,the fe...
关键词：Telomere G-quadruplex SUNITINIB BERBERINE Synergistic effects 
Comparison of efficacy and safety among axitinib,sunitinib,and sorafenib as neoadjuvant therapy for renal cell carcinoma:a retrospective study被引量：4
《Cancer Communications》2019年第1期510-513,共4页Wen Cai Biao Cai Juan Zhou Yonghui Chen Jin Zhang Yiran Huang Wei Xue Jiwei Huang 
This study was supported by the research project of Shanghai Science and Technology Commission(18ZR1423200);the Incubating Program for Clinical Research and Innovation of Renji Hospital(PYXJS16-008);the Shen Kang 3-year action plan program(16CR3062B)
Dear editor,Renal cancer accounts for approximately 2%of all can-cer deaths worldwide,and renal cell carcinoma(RCC)is the predominant subtype[1].Radiotherapy and chemo-therapy have been found to have limited roles in ...
关键词：RENAL THERAPY treatment 
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