TISSUE-SPECIFIC

作品数：76被引量：238H指数：8
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From metabolic regulation to kidney protection: β-arrestin 2 as a dual-function therapeutic target
《World Journal of Diabetes》2025年第3期273-276,共4页Jian Yang Cheng-Zhi Zhang Jing Zhang 
Supported by National Natural Science Foundation of China,No.82471616,No.82170418,and No.82271618;Natural Science Foundation of Hubei Province,No.2022CFA015;Central Guiding Local Science and Technology Development Project,No.2022BGE237;Key Research and Development Program of Hubei Province,No.2022BCE001,and No.2023BCB139;Hubei Provincial Health Commission Project,No.WJ2023M151。
We are deeply interested in the recent findings onβ-arrestin 2.Liu et al demonstrated thatβ-arrestin 2 knockout provides significant protection in diabetic nephropathy,underscoring its potential as a promising thera...
关键词：Type 2 diabetes Diabetic nephropathy β-arrestin 2 β-arrestin 1 Metabolic regulation Tissue-specific signaling Therapeutic strategies Multi-target therapies 
Epigenetic basis for the establishment of ruminal tissue-specific functions in bovine fetuses and adults
《Journal of Genetics and Genomics》2025年第1期78-92,共15页Jing Wang Wen Yuan Fang Liu Guangbo Liu Xiaoxiong Geng Chen Li Chenchen Zhang Nan Li Xueling Li 
funded by the Science and Technology Major Project of the Inner Mongolia Autonomous Region of China to the State Key Laboratory of Reproductive Regulation(2023KYPT0010 and 2021ZD0048);STI 2030-Major Projects(2023ZD0407504)of China;the development plan for young scientific and technological talents in colleges and universities of Inner Mongolia Autonomous Region of China(NMGIRT2204);the National Natural Science Foundation of China(32160172).
Epigenetic regulation in the rumen,a unique ruminant organ,remains largely unexplored compared with other tissues studied in model species.In this study,we perform an in-depth analysis of the epigenetic and transcript...
关键词：RUMEN EPIGENETICS DNA methylation tsDMRs ENHANCERS 
Whole-genome methylation reveals tissue-specific differences in non-CG methylation in bovine
《Zoological Research》2024年第6期1371-1384,共14页Jing Wang Wen Yuan Fang Liu Guang-Bo Liu Xiao-Xiong Geng Chen Li Chen-Chen Zhang Nan Li Xue-Ling Li 
supported by the STI 2030-Major Projects(2023ZD0407504)of China;Development Plan for Young Scientific and Technological Talents in Colleges and Universities of Inner Mongolia Autonomous Region of China(NMGIRT2204);National Natural Science Foundation of China(32160172);Science and Technology Major Project of the Inner Mongolia Autonomous Region of China to the State Key Laboratory of Reproductive Regulation(2021ZD0048&2023KYPT0010)。
DNA methylation at non-CG dinucleotides(mCH,H=A,C,T)widely occurs and plays an important role in specific cell types,including pluripotent,neural,and germ cells.However,the functions and regulatory mechanisms of mCH,p...
关键词：EPIGENETICS Non-CG Methylation CHDMRs Comparative Genomics Developmental Biology 
Elevated accumulation and distinct migration patterns of neonicotinoids compared to traditional insecticides in South China typical orchard
《Emerging Contaminants》2024年第4期207-217,共11页Shiming Song Xu Li Fenghua Wei Jiye Zhang Henglin Zhang Haibao Huang Yuankai Guo Tao Zhang 
The Natural Science Foundation of China(No.22022612,No.22036004,No.22306209,and No.42307369);Natural Science Foundation of Guangdong Province,China(No.2020A0104006 and No.2021A1515010243);China Postdoctoral Science Foundation(No.2022M723587 and No.2023T160747);Department of Education of Guangdong Province(No.2021KQNCX087)are acknowledged for their partial research support.
The global insecticide market is undergoing significant changes,witnessing a surge in neonicotinoids(NEOs)usage,alongside the persistent application of traditional insecticides,such as organophosphates(OPs),carbamates...
关键词：Residues Neonicotinoid insecticides POMELO Tissue-specific distribution Migration pathway 
Inference and prioritization of tissue-specific regulons in Arabidopsis and Oryza
《aBIOTECH》2024年第3期309-324,共16页Honggang Dai Yaxin Fan Yichao Mei Ling-Ling Chen Junxiang Gao 
supported in part by the National Natural Science Foundation of China(32270712);the Hubei Provincial Natural Science Foundation of China(2019CFA014).
A regulon refers to a group of genes regulated by a transcription factor binding to regulatory motifs to achieve specific biological functions.To infer tissue-specific gene regulons in Arabidopsis,we developed a novel...
关键词：Transcriptional regulation Graph convolutional network TISSUE-SPECIFIC REGULON Transcription factor 
Tissue-specific antiviral immunity
《Cellular & Molecular Immunology》2024年第9期941-942,共2页Stipan Jonjić 
In addition to its critical function of protecting us against pathogens,an essential feature of the immune system is its compartmentalization,which is crucial for maintaining immune homeostasis in different organs and...
关键词：ORGANS HOMEOSTASIS IMMUNITY 
Tissue-specific features of innate lymphoid cells in antiviral defense被引量：2
《Cellular & Molecular Immunology》2024年第9期1036-1050,共15页Sytse J.Piersma 
Innate lymphocytes(ILCs)rapidly respond to and protect against invading pathogens and cancer.ILCs include natural killer(NK)cells,ILC1s,ILC2s,ILC3s,and lymphoid tissue inducer(LTi)cells and include type I,type II,and ...
关键词：NK cell innate lymphoid cell tissue microenvironment virus infection anti-viral immunity 
Pig H3K4me3,H3K27ac,and gene expression profiles reveal reproductive tissue-specific activity of transposable elements被引量：1
《Zoological Research》2024年第1期138-151,共14页Tao Jiang Zhi-Min Zhou Zi-Qi Ling Qing Zhang Zhong-Zi Wu Jia-Wen Yang Si-Yu Yang Bin Yang Lu-Sheng Huang 
supported by the National Natural Science Foundation of China(32160781)。
Regulatory sequences and transposable elements(TEs)account for a large proportion of the genomic sequences of species;however,their roles in gene transcription,especially tissue-specific expression,remain largely unkn...
关键词：Transposable elements PORCINE Histone modification Alternative promoter TE-containing transcript 
Instant trachea reconstruction using 3D-bioprinted C-shape biomimetic trachea based on tissue-specific matrix hydrogels
《Bioactive Materials》2024年第2期52-65,共14页Yuyan Sun Yingying Huo Xinyue Ran Hongying Chen Qingqing Pan Yujie Chen Ying Zhang Wenjie Ren Xiaoyun Wang Guangdong Zhou Yujie Hua 
financially supported by the National Key Research and Development Program of China(2022YFA1207500);Biomaterials and Regenerative Medicine Institute Cooperative Research Project of Shanghai Jiaotong University School of Medicine(2022LHA07);the National Natural Science Foundation of China(82302823,81871502 and 81671837);the Key Research and Development Program of Henan Province(221111310100);Major Science and Technology Projects of Xinxiang City(21ZD006);Shanghai Municipal Science and Technology Major Project(21Y11911700);Science and Technology Innovation Action Plan Venus Project(Sailing Special Project,23YF1421400);the China Postdoctoral Science Foundation(2023M732294);Shanghai Municipal Key Clinical Specialty(shslczdzk06601).
Currently,3D-bioprinting technique has emerged as a promising strategy to offer native-like tracheal substitutes for segmental trachea reconstruction.However,there has been very limited breakthrough in tracheal repair...
关键词：Trachea reconstruction 3D-bioprinting HYDROGELS Biomimetic architecture 
Tissue-specific trace elements concentration and human health risk assessment in three marine fish species from Visakhapatnam to Kakinada coasts
《Radiation Detection Technology and Methods》2023年第4期611-626,共16页A.Jaya Sree A.Srinivasulu Tanushree Panigrahi B.Aruna Jaganmoy Biswas A.D.P.Rao 
Purpose The current study was aimed to evaluate the bioaccumulation of elements(As,Cd,Cu,Fe,Mn,Se and Zn)in the gills,liver and muscle of three distinct marine fish species,namely Nemipterus japonicas,Upeneus vittatus...
关键词：Health risk assessment Marine fish species-Trace elements Tissue specific 
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