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  • 期刊=Signal Transduction and Targeted Therapyx
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Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1
《Signal Transduction and Targeted Therapy》2025年第1期240-255,共16页Yanni Lin Ling Li Bin Yuan Fei Luo Xiujuan Zhang Yuanjun Yang Shaliu Luo Jing Lin Tianxing Ye Youzhi Zhang Shan Gao Qinong Ye 
supported by the National Natural Science Foundation of China(81930078 and 82330083 to Q.Y.and 81902838 to L.L.);the National Key Research and Development Program of China(2022YFA1104003 to Q.Y.);Natural Science Foundation of Beijing(7204284 to L.L.);Basic and Clinical Collaborative Research Enhanced Program of Anhui Medical University(2021xkjT025 to B.Y.);the Doctoral Start-up Foundation of Anhui Medical University(0110050201 to B.Y.).
Aerobic glycolysis is a hallmark of cancer and is regulated by growth factors,protein kinases and transcription factors.However,it remains poorly understood how these components interact to regulate aerobic glycolysis...
关键词：metabolism programming SINE 
Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell(cDC1)activation and tumor infiltration
《Signal Transduction and Targeted Therapy》2024年第6期2804-2818,共15页Fenglian He Zhongen Wu Chenglong Liu Yuanyuan Zhu Yan Zhou Enming Tian Rina Rosin-Arbesfeld Dehua Yang Ming-Wei Wang Di Zhu 
the National Natural Science Foundation of China with grants 81872895 and 82073881 awarded to D.Z.,and 81872915,82073904,and 82011530150 to M.-W.W.;the Shanghai Municipal Education Commission under the Shanghai Top-Level University Capacity Building Program(DGF817029-04 to M.-W.W.);the Shanghai Science and Technology Commission with grants 18ZR1403900,20430713600,and 18JC1413800 to D.Z;Innovative Drug and Evaluation Innovation Team for Tumor Immunotherapy of Jinan Science and Technology Bureau(No.2020GXRC041 to D.Z.);funded by the Fudan School of Pharmacy and Minhang Hospital Joint Research Fund(RO-MY201712 to D.Z.);the Fudan-SIMM Joint Research Fund(FU-SIMM20181010 to D.Z.and D.Y.).
Conventional type 1 dendritic cells(cDC1)are the essential antigen-presenting DC subset in antitumor immunity.Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like(BCL9/BCL9L)inhibits tumor growth and boosts immune...
关键词：IMMUNITY TARGETING markedly 
Combating inconsistent evaluation of intra-tumor immune status by a novel transcriptomic signature in hepatocellular carcinoma
《Signal Transduction and Targeted Therapy》2023年第3期895-897,共3页Linmeng Zhang Ning Tang Chen Yang Haigang Geng Hualian Hang Wenxin Qin Cun Wang 
This work was supported by the National Natural Science Foundation of China(81920108025,81874229,82072633,and 82122047);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZLCX20211602);Shanghai Natural Science Foundation(22ZR1480900).
Dear Editor,Harnessing the power of the immune system via immune checkpoint inhibition has revolutionized the treatment paradigm of many malignancies,including hepatocellular carcinoma(HCC).1 Despite encouraging effic...
关键词：HEPATOCELLULAR SIGNATURE inconsistent 
Deconstructing the intra-tumor subclonal heterogeneity of lung synchronous ground-glass nodules using whole-genome sequencing
《Signal Transduction and Targeted Therapy》2022年第6期1888-1890,共3页Yijiu Ren Minfang Song Yunlang She Huikang Xie Hui Zheng Chang Chen Yiwen Zhang 
funded by the projects from the National Natural Science Foundation of China(91959126);Shanghai Hospital Development Center(SHDC12017114);Shanghai Pulmonary Hospital Innovation Team(FKCX1906,FKXY1902,FKLY2007,FK1943);Shanghai Science and Technology Committee(20YF1441100,20XD1403000,18DZ2293400).
Dear Editor,The persistent presence of ground-glass opacity nodules(GGN)on thin-section computed tomography(CT)usually suggests the presence of lung adenocarcinoma,1 which include atypical adenomatous hyperplasia(AAH)...
关键词：LUNG diagnosis glass 
Sox2 induces glioblastoma cell sternness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications被引量：5
《Signal Transduction and Targeted Therapy》2022年第3期790-801,共12页Hernando Lopez-Bertoni Amanda Johnson Yuan Rui Bachchu Lai Sophie Sail Maureen Malloy Jonathan BCoulter Maria Lugo-Fagundo Sweta Shudir Harmon Khela Christopher Caputo Jordan J.Green John Laterra 
DNA methylation is a reversible process catalyzed by the ten-eleven translocation(TET)family of enzymes(TET1,TET2,TET3)that convert 5-methylcytosine(5mC)to 5-hydroxymethylcytosine(5hmC).Altered patterns of 5hmC and 5m...
关键词：TET2 5hmC CONVERT 
XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer被引量：3
《Signal Transduction and Targeted Therapy》2021年第11期3304-3317,共14页Yahui Zhao Weina Zhang Miaomiao Huo Peng Wang Xianghe Liu Yu Wang Yinuo Li Zhixiang Zhou Ningzhi Xu Hongxia Zhu 
This work was supported by the National Natural Science Foundation of China(81772638 and 81903025);CAMS Innovation Fund for Medical Sciences(2016-I2M-1-001).
Macrophages are among the most abundant immune cells in colorectal cancer (CRC). Re-educating tumor-associated macrophages (TAMs) to switch from protumoral to anti-tumoral activity is an attractive treatment strategy ...
关键词：COLORECTAL inhibited thereby 
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