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作品数：191被引量：560H指数：12
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Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury被引量：33
《Cell Research》2019年第12期1009-1026,共18页Shuyong Wang Xuan Wang Zuolong Tan Yuxin Su Juan Liu Mingyang Chang Fang Yan Jie Chen Tao Chen Chuanjiang Li Jie Hu Yunfang Wang 
the National Natural Science Foundations of China(No.81730052);the Interdisciplinary Cooperation Project of Beijing Nova Program(Z1811100006218127);the National Major Scientific and Technological Special Project for"Significant New Drugs Development"(2018ZX09711003-001-002);the National Key Research and Development Program of China(No.2016YFC1101305);the Science and Technology Planning Project of Guangdong China(2015A050502023);the Guangdong Province Science and Technology Program(2018KJYZ021);Science and Technology Program of Guangzhou,China(STPG;2016201604030054).
We report the generation of human ESC-derived,expandable hepatic organoids(hEHOs)using our newly established method with wholly defined(serum-free,feeder free)media.The hEHOs stably maintain phenotypic features of bip...
关键词：HEPATIC enable MAINTAIN 
Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis被引量：23
《Cell Research》2019年第7期548-561,共14页Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He 
supported in part by the State Key Program of the National Natural Science Foundation of China(81430014);the National Natural Science Foundation of China(81660103,81771674 and 81860654);111 Project(D17011);the National Institutes of Health(R01DK102912);Guangxi BaGui Scholars,Project of Guangxi Health and Family Planning Commission(S201602);Basic Ability Promotion Project of Guangxi(2017KY0481);Natural Science Foundation of Gyangxi(2015GXNSFFA139004,2016JJB140027);the Project of Traditional Chinese Medicine of Guangxi Health and Family Planning Commission(GZLC16-47);the Project of Guangxi University Collaborative Innovation Center;Guangxi Digestive Disease Clinical Medical Research Center Construction Project(AD17129027).
Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention...
关键词：COMPLEMENT disease AFLD 
CircRNA-derived pseudogenes被引量：21
《Cell Research》2016年第6期747-750,共4页Rui Dong Xiao-Ou Zhang Yang Zhang Xu-Kai Ma Ling-Ling Chen Li Yang 
Acknowledgments We are grateful to Gordon Carmichael for reading the manuscript. Next generation deep sequencing was performed at the CAS-MPG Partner Institute for Computational Biology Omits Core, Shanghai, China. This work is supported by grants 2014CB964800 and 2014CB910600 from the Ministry of Science and Technology of China, and grants 91540115, 91440202 and 31471241 from the National Natural Science Foundation of China.
Circular RNAs （circRNAs） from pre-mRNA back-splicing have been recently re-discovered ge- nome-wide in metazoans by taking advantage of RNA deep-sequencing （RNA-seq） of the non-polyadenylated transcriptomes and sp...
关键词：期刊 编辑工作 规范 写作方法 
hESC-derived pancreatic progenitors
《Cell Research》2013年第5期592-594,共3页Lina Sui Guang-Hui Liu Juan Carlos Izpisua Belmonte 
Successful derivation of pancreatic progenitors from human embryonic stem ceils （hESCs） in vitro and further differentiation towards functional p cells in vivo may create the possibility of using hESC-derived pancre...
关键词：人类胚胎干细胞 祖细胞 胰腺 衍生 细胞分化 细胞来源 替代治疗 P细胞 
A novel class of tRNA-derived small RNAs extremely en- riched in mature mouse sperm被引量：27
《Cell Research》2012年第11期1609-1612,共4页HongyingPeng  JunchaoShi  YingZhang  HeZhang  ShangyingLiao  WeiLi  LiLei  ChunshengHan  LinaNing  YujingCao  QiZhou  QiChen EnkuiDuan 
Dear editor, The discovery of sperm-borne RNAs (mRNAs and small non-coding RNAs) has opened the possibility of additional paternal contributions aside from provid- ing the DNA [1]. It has been reported that the incom...
关键词：小分子RNA 精子成熟 雄性小鼠 TRNA RT-PCR分析 miRNA 富集 衍生 
Deficit of mitochondria-derived ATP during oxidative stress impairs mouse MII oocyte spindles被引量：25
《Cell Research》2006年第10期841-850,共10页Xiao Zhang Xue Qing Wu Shuang Lu Ying Lu Guo Xu Ma 
Although the role of oxidative stress in maternal aging and infertility has been suggested, the underlying mechanisms are not fully understood. The present study is designed to determine the relationship between mitoc...
关键词：spindle oxidative stress mitochondria permeability transition pore ATP 
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