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Mitochondria-derived vesicles:New players in the game of neurodegeneration
《Neural Regeneration Research》2026年第2期679-680,共2页Laura Palumbo Domenico Nuzzo Antonella Girgenti Pasquale Picone 
supported by project Emerging Infectious Diseases One Health Basic and Translational Research Actions addressing Unmet Needs on Emerging Infectious Diseases,INF-ACT,Spoke 1 and Spoke 5,Project number PE00000007,CUP B53C20040570005(to PP and DN).
Introduction:One of the main events that regulate a cell’s well-being is cell-to-cell communication.This intercellular mechanism of information transfer is often mediated by vesicular trafficking.Mitochondrial-derive...
关键词：extracellular vesicles cell cell communication vesicular traffickingmitochondrial derived NEURODEGENERATION mitochondria derived vesicles vesicular trafficking extracellular vesicle ev first 
tRNA-derived small RNAs in digestive tract diseases:Progress and perspectives
《Genes & Diseases》2025年第3期253-264,共12页Mingrui Liu Xiaojun Zhuang Haiqing Zhang Weidong Ji Gang Yuan 
supported by the National Natural Science Foundation of China(No.82073047,82272995);Guangdong Provincial Basic and Applied Basic Research Foundation Natural Science Foundation(China)(No.2022A1515010954).
tRNA-derived small RNAs (tsRNAs) are non-coding small RNAs that are producedthrough the precise cleavage of tRNA molecules under specific conditions. tsRNA has multiplefunctions, including inhibiting translation, acti...
关键词：BIOGENESIS Biological function Digestive tract diseases Mechanism tRNA-derived small RNAs(tsRNAs) 
A New Cybersecurity Approach Enhanced by xAI-Derived Rules to Improve Network Intrusion Detection and SIEM
《Computers, Materials & Continua》2025年第5期1607-1621,共15页Federica Uccello Marek Pawlicki Salvatore D'Antonio RafałKozik MichałChoras 
funded under the Horizon Europe AI4CYBER Project;which has received funding from the European Union’s Horizon Europe Research and Innovation Programme under grant agreement No.101070450.
The growing sophistication of cyberthreats,among others the Distributed Denial of Service attacks,has exposed limitations in traditional rule-based Security Information and Event Management systems.While machine learn...
关键词：CYBERSECURITY explainable artificial intelligence intrusion detection system rule-based SIEM distributed denial of service 
Fibrous scaffolds loaded with BMSC-derived apoptotic vesicles promote wound healing by inducing macrophage polarization
《Genes & Diseases》2025年第2期398-413,共16页Xudong Su Jianye Yang Zhenghao Xu Li Wei Shuhao Yang Feilong Li Min Sun Yingkun Hu Wenge He Chen Zhao Li Chen Yonghua Yuan Leilei Qin Ning Hu 
supported by the National Natural Science Foundation of China (No.82072443,82372425);the Chongqing Outstanding Project of Overseas Chinese Entrepreneurship and Innovation Support Program (China) (No.CX2022032);the Articular Cartilage Tissue Engineering and Regenerative Medicine Team,Chongqing Medical University (No.W0080);the General Project of Natural Science Foundation of Chongqing,China (No.CSTB2023NSCQMSX0166);the"Tomorrow Cup"Teacher-Student Cocreation Teaching and Research Innovation Project of International Medical College of Chongqing Medical University (No.KY20220204);the Chengdu Medical Research Project (Sichuan,China) (No.2023191);the China Postdoctoral Science Foundation (No.2022M710557);the Natural Science Foundation of Chongqing,China (No.CSTB2023NSCQBHx0011);the Young Excellent Science and Technology Talent Project of the First Affiliated Hospital of Chongqing Medical University (No.ZYRC2022-05).
Macrophages play a key role in wound healing.Dysfunction of their MO polarization to M2 leads to disorders of the wound immune microenvironment and chronic inflammation,which affects wound healing.Regulating the polar...
关键词：Apoptotic body Extracellular vesicles Macrophage polarization Mesenchymal stem cells miR-21a-5p POLYCAPROLACTONE Wound healing 
MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model
《World Journal of Stem Cells》2025年第3期81-101,共21页Jing-Jun Jin Rong-Hua Liu Jin-Yan Chen Kun Wang Jun-Yong Han Dao-Shun Nie Yu-Qing Gong Bin Lin Guo-Xing Weng 
Supported by the Nonprofit Research Institutes Foundation of Fujian Province,China,No.2021R1012005 and No.2021R1012003.
BACKGROUND Heart disease remains a leading cause of mortality worldwide,with existing treatments often failing to effectively restore damaged myocardium.Humaninduced pluripotent stem cells(hiPSCs)and their derivatives...
关键词：Human-induced pluripotent stem cells Human-induced pluripotent stem cell-derived cardiomyocytes Myocardial infarction EXOSOMES MicroRNA 21-5p Apoptosis 
Efficacy of disitamab vedotin-containing therapy in metastatic colorectal cancer: A case report
《World Journal of Clinical Oncology》2025年第3期116-122,共7页Hu-Cheng Yan Yan Liu You Feng Jun-Ming Li Lei-Ming Sheng Xin Chen Yu-Ping Xie Na Li 
BACKGROUND Colorectal cancer(CRC)is a leading cause of cancer-related mortality worldwide.In cases of metastatic CRC(mCRC)that are resistant to conventional chemo-therapy-based treatments,the efficacy of available the...
关键词：Disitamab vedotin Human epidermal growth factor receptor 2 Overex-pression Metastatic colorectal cancer EFFICACY Case report 
hUCMSC-derived extracellular vesicles relieve cisplatin-induced granulosa cell apoptosis in mice by transferring antiapoptotic miRNAs
《Journal of Biomedical Research》2025年第1期36-49,共14页Wenjing Tang Haiyan Yan Xiaojun Chen Yanan Pu Xin Qi Liyang Dong Chuan Su 
Financial support for the current study was provided by the grant from"Blue Engineering"Excellent Young Teacher Foundation in Colleges and Universities of Jiangsu Province(Grant No.KY101R202207 to Xiaojun Chen)。
Premature ovarian insufficiency(POI)caused by chemotherapy is a common complication in female cancer survivors of childbearing age.Traditional methods,including mesenchymal stem cell(MSC)transplant and hormone replace...
关键词：CHEMOTHERAPY fertility preservation extracellular vesicles granulosa cell apoptosis microRNAs 
Deep phenotyping of testosterone-prompted fibrosis in arrhythmogenic right ventricular cardiomyopathy using iPSC-derived engineered cardiac spheroids
《Bio-Design and Manufacturing》2025年第1期20-35,I0002-I0012,共27页Hongyi Cheng Xinrui Wang Sichong Qian Yike Zhang Jincheng Jiao Bingyu Zheng Yue Zhu Hua Xu Jia Song Feng Zhang Xiaohong Jiang Chang Cui Minglong Chen 
supported by the National Natural Science Foundation of China(Nos.82370322 to CC,82200352 to FZ,82300352 to YZ,22275034 to HX,and 82070343 to MLC);the Natural Science Foundation of Jiangsu Province of China(Nos.BK20220710 to FZ and BK20230733 to YZ);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.JX13414086 to HYC).
Arrhythmogenic right ventricular cardiomyopathy(ARVC)is a progressive disease characterized by adipose and fibrous replacement of the myocardium.While elevated testosterone levels have been implicated in the pathologi...
关键词：Arrhythmogenic right ventricular cardiomyopathy(ARVC) Gender difference Cardiac spheroids Testoste-rone FIBROSIS 
Melanoma-derived extracellular vesicles transfer proangiogenic factors
《Oncology Research》2025年第2期245-262,共18页MAGDALENA WILCZAK MAGDALENA SURMAN MAŁGORZATA PRZYBYŁO 
supported by grants from the Jagiellonian University,Poland(N18/DBS/000007);the Polish National Science Centre(2018/31/N/NZ4/03787).
Angiogenesis,the expansion of pre-existing vascular networks,is crucial for normal organ growth and tissue repair,but is also involved in various pathologies,including inflammation,ischemia,diabetes,and cancer.In soli...
关键词：Angiogenesis EXOSOMES Extracellular Vesicles(EVs) MELANOMA MICROVESICLES 
Human iPSC-derived mesenchymal stem cells relieve high blood pressure in spontaneously hypertensive rats via splenic nerve activated choline acetyltransferase-positive cells
《Science China(Life Sciences)》2025年第2期502-514,共13页Zhen Zhang Weijun Huang Xiaoran Zhang Zhecun Wang Manting Xie Bingbing Xie Yiling Wang Xiaoyong Chen Andy Peng Xiang Qiuling Xiang 
supported by the National Natural Science Foundation of China(82272164,82470367);the Natural Science Foundation of Guangdong Province(2019A1515010066,2021A1515011648,2024A1515013135);the Guangzhou Science,Technology and Innovation Commission(202002020004)。
Despite substantial advancements in modern medicine,the management of hypertension remains a major challenge.Stem cell-based therapies have recently demonstrated remarkable efficacy in treating cardiovascular diseases...
关键词：hiPSC-MSCs hypertension splenic nerve ChAT+cells 
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