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Fibrous scaffolds loaded with BMSC-derived apoptotic vesicles promote wound healing by inducing macrophage polarization
《Genes & Diseases》2025年第2期398-413,共16页Xudong Su Jianye Yang Zhenghao Xu Li Wei Shuhao Yang Feilong Li Min Sun Yingkun Hu Wenge He Chen Zhao Li Chen Yonghua Yuan Leilei Qin Ning Hu 
supported by the National Natural Science Foundation of China (No.82072443,82372425);the Chongqing Outstanding Project of Overseas Chinese Entrepreneurship and Innovation Support Program (China) (No.CX2022032);the Articular Cartilage Tissue Engineering and Regenerative Medicine Team,Chongqing Medical University (No.W0080);the General Project of Natural Science Foundation of Chongqing,China (No.CSTB2023NSCQMSX0166);the"Tomorrow Cup"Teacher-Student Cocreation Teaching and Research Innovation Project of International Medical College of Chongqing Medical University (No.KY20220204);the Chengdu Medical Research Project (Sichuan,China) (No.2023191);the China Postdoctoral Science Foundation (No.2022M710557);the Natural Science Foundation of Chongqing,China (No.CSTB2023NSCQBHx0011);the Young Excellent Science and Technology Talent Project of the First Affiliated Hospital of Chongqing Medical University (No.ZYRC2022-05).
Macrophages play a key role in wound healing.Dysfunction of their MO polarization to M2 leads to disorders of the wound immune microenvironment and chronic inflammation,which affects wound healing.Regulating the polar...
关键词：Apoptotic body Extracellular vesicles Macrophage polarization Mesenchymal stem cells miR-21a-5p POLYCAPROLACTONE Wound healing 
MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model
《World Journal of Stem Cells》2025年第3期81-101,共21页Jing-Jun Jin Rong-Hua Liu Jin-Yan Chen Kun Wang Jun-Yong Han Dao-Shun Nie Yu-Qing Gong Bin Lin Guo-Xing Weng 
Supported by the Nonprofit Research Institutes Foundation of Fujian Province,China,No.2021R1012005 and No.2021R1012003.
BACKGROUND Heart disease remains a leading cause of mortality worldwide,with existing treatments often failing to effectively restore damaged myocardium.Humaninduced pluripotent stem cells(hiPSCs)and their derivatives...
关键词：Human-induced pluripotent stem cells Human-induced pluripotent stem cell-derived cardiomyocytes Myocardial infarction EXOSOMES MicroRNA 21-5p Apoptosis 
Efficacy of disitamab vedotin-containing therapy in metastatic colorectal cancer: A case report
《World Journal of Clinical Oncology》2025年第3期116-122,共7页Hu-Cheng Yan Yan Liu You Feng Jun-Ming Li Lei-Ming Sheng Xin Chen Yu-Ping Xie Na Li 
BACKGROUND Colorectal cancer(CRC)is a leading cause of cancer-related mortality worldwide.In cases of metastatic CRC(mCRC)that are resistant to conventional chemo-therapy-based treatments,the efficacy of available the...
关键词：Disitamab vedotin Human epidermal growth factor receptor 2 Overex-pression Metastatic colorectal cancer EFFICACY Case report 
hUCMSC-derived extracellular vesicles relieve cisplatin-induced granulosa cell apoptosis in mice by transferring antiapoptotic miRNAs
《Journal of Biomedical Research》2025年第1期36-49,共14页Wenjing Tang Haiyan Yan Xiaojun Chen Yanan Pu Xin Qi Liyang Dong Chuan Su 
Financial support for the current study was provided by the grant from"Blue Engineering"Excellent Young Teacher Foundation in Colleges and Universities of Jiangsu Province(Grant No.KY101R202207 to Xiaojun Chen)。
Premature ovarian insufficiency(POI)caused by chemotherapy is a common complication in female cancer survivors of childbearing age.Traditional methods,including mesenchymal stem cell(MSC)transplant and hormone replace...
关键词：CHEMOTHERAPY fertility preservation extracellular vesicles granulosa cell apoptosis microRNAs 
Deep phenotyping of testosterone-prompted fibrosis in arrhythmogenic right ventricular cardiomyopathy using iPSC-derived engineered cardiac spheroids
《Bio-Design and Manufacturing》2025年第1期20-35,I0002-I0012,共27页Hongyi Cheng Xinrui Wang Sichong Qian Yike Zhang Jincheng Jiao Bingyu Zheng Yue Zhu Hua Xu Jia Song Feng Zhang Xiaohong Jiang Chang Cui Minglong Chen 
supported by the National Natural Science Foundation of China(Nos.82370322 to CC,82200352 to FZ,82300352 to YZ,22275034 to HX,and 82070343 to MLC);the Natural Science Foundation of Jiangsu Province of China(Nos.BK20220710 to FZ and BK20230733 to YZ);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.JX13414086 to HYC).
Arrhythmogenic right ventricular cardiomyopathy(ARVC)is a progressive disease characterized by adipose and fibrous replacement of the myocardium.While elevated testosterone levels have been implicated in the pathologi...
关键词：Arrhythmogenic right ventricular cardiomyopathy(ARVC) Gender difference Cardiac spheroids Testoste-rone FIBROSIS 
Human iPSC-derived mesenchymal stem cells relieve high blood pressure in spontaneously hypertensive rats via splenic nerve activated choline acetyltransferase-positive cells
《Science China(Life Sciences)》2025年第2期502-514,共13页Zhen Zhang Weijun Huang Xiaoran Zhang Zhecun Wang Manting Xie Bingbing Xie Yiling Wang Xiaoyong Chen Andy Peng Xiang Qiuling Xiang 
supported by the National Natural Science Foundation of China(82272164,82470367);the Natural Science Foundation of Guangdong Province(2019A1515010066,2021A1515011648,2024A1515013135);the Guangzhou Science,Technology and Innovation Commission(202002020004)。
Despite substantial advancements in modern medicine,the management of hypertension remains a major challenge.Stem cell-based therapies have recently demonstrated remarkable efficacy in treating cardiovascular diseases...
关键词：hiPSC-MSCs hypertension splenic nerve ChAT+cells 
Corrigendum to“Wharton’s jelly MSC-derived extracellular vehicles-loaded hyaluronic acid-alginate adhesives for treatment of osteoarthritis”[journalofmaterialsscience&technology,volume142,10 April 2023,Pages 240-252]
《Journal of Materials Science & Technology》2024年第35期267-268,共2页Yanhong Zhao Xige Zhao Hainan Xu Yi Xing Tengling Wu Xun Sun Mingjie Kuang Xinlong Ma Wenguang Liu Qiang Yang 
The authors regret that during the assembly of Fig.7,they inadvertently pasted the wrong tibial plateau of“12 w hWJMSC-sEVs”group.The correct Fig.7 should be as below。
关键词：Cor loaded journal 
TDERS,an exosome RNA-derived signature predicts prognosis and immunotherapeutic response in clear cell renal cell cancer:a multicohort study
《Journal of the National Cancer Center》2024年第4期382-394,共13页Aimin Jiang Ying Liu Ziwei He Wenqiang Liu Qiwei Yang Yu Fang Baohua Zhu Xiaofeng Wu Huamao Ye Bicheng Ye Shunxiang Gao Le Qu Wenhao Xu Peng Luo Linhui Wang 
funded by grants from the National Natural Science Foundation of China(grant numbers:82002664,81872074,81772740,82173345 and 82373154);the Hanghai Jiading District Health Commission Scientific Research Project Youth Fund(grant num-ber:2020-QN-02);the Meng Chao Talent Training Plan-Youth Re-search Talent Training Program of Eastern Hepatobiliary Surgery Hos-pital and the Foundation for Distinguished Youths of Jiangsu Province(grant number:BK20200006).
Background:Tumor-derived exosomes are involved in tumor progression and immune invasion and might func-tion as promising noninvasive approaches for clinical management.However,there are few reports on exosom-based mar...
关键词：Renal cell carcinoma EXOSOME Non-invasive biopsy Immunotherapy response Multiomics PLOD2 
From follicle to blastocyst:microRNA-34c from follicular flui-derived extracellular vesicles modulates blastocyst quality
《Journal of Animal Science and Biotechnology》2024年第6期2276-2292,共17页Camilla Benedetti Krishna Chaitanya Pavani Yannick Gansemans Nima Azari‑Dolatabad Osvaldo Bogado Pascottini Luc Peelman Rani Six Yuan Fan Xuefeng Guan Koen Deserranno Andrea Fernandez‑Montoro Joachim Hamacher Filip Van Nieuwerburgh Trudee Fair An Hendrix Katrien Smits Ann Van Soom 
supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 860960;by Bijzonder Onderzoeksfonds GOA(Geconcerteerde onderzoeksacties)2018000504(GOA030-18 BOF);supported by the Research Foundation Flanders(FWO)(grant numbers:1228821N and 12A2H24N)。
Background Within the follicular fluid,extracellular vesicles(EVs)guide oocyte growth through their cargo microRNAs(miRNAs).Here,we inv estigated the role of EVs and their cargo miRNAs by linking the miRNAs found in E...
关键词：Developmental competence Extracellular vesicles MATURATION MicroRNA miR-34c OOCYTE 
A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes
《International Journal of Oral Science》2024年第4期782-796,共15页Lingxiao Wang Haoqing Yang Chen Zhang Yue Zhang Yilin He Yang Liu Pan Ma Jun Li Zhipeng Fan 
supported by the National Key Research and Development Program(2022YFA1104401);CAMS Innovation Fund for Medical Sciences(2019-I2M-5-031 to Z.P.F.);grants from Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(No.CXTD202204 to Z.P.F.);the National Natural Science Foundation of China(No.82401155 to L.X.W.);R&D Program of Beijing Municipal Education Commission(KM202410025007);Training Fund for Open Projects at Clinical Institutes and Departments of Capital Medical University(CCMU2024ZKYXZ002);the Young Scientist Program of Beijing Stomatological Hospital,Capital Medical University,No.YSP202208。
Blood glucose fluctuation leads to poor bone defect repair in patients with type 2 diabetes(T2DM).Strategies to safely and efficiently improve the bone regeneration disorder caused by blood glucose fluctuation are sti...
关键词：Blood FUNCTION promoted 
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