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作品数：191被引量：560H指数：12
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Human iPSC-derived mesenchymal stem cells relieve high blood pressure in spontaneously hypertensive rats via splenic nerve activated choline acetyltransferase-positive cells
《Science China(Life Sciences)》2025年第2期502-514,共13页Zhen Zhang Weijun Huang Xiaoran Zhang Zhecun Wang Manting Xie Bingbing Xie Yiling Wang Xiaoyong Chen Andy Peng Xiang Qiuling Xiang 
supported by the National Natural Science Foundation of China(82272164,82470367);the Natural Science Foundation of Guangdong Province(2019A1515010066,2021A1515011648,2024A1515013135);the Guangzhou Science,Technology and Innovation Commission(202002020004)。
Despite substantial advancements in modern medicine,the management of hypertension remains a major challenge.Stem cell-based therapies have recently demonstrated remarkable efficacy in treating cardiovascular diseases...
关键词：hiPSC-MSCs hypertension splenic nerve ChAT+cells 
Turning point of organoid transplantation:first-in-human trial of iPSC-derived retinal organoid grafting in patients with retinitis pigmentosa
《Science China(Life Sciences)》2024年第5期1082-1084,共3页Chang-Jun Zhang Zi-Bing Jin 
partly supported by the National Science Fund for Distinguished Young Scholars(82125007)。
The discovery of induced pluripotent stem cells(iPSCs)has revolutionized the field of disease research,providing a promising platform for studying various conditions.Over the last decade,significant progress has been ...
关键词：conditions PATIENTS RETINITIS 
A 5′tRNA-Ala-derived small RNA regulates anti-fungal defense in plants被引量：4
《Science China(Life Sciences)》2022年第1期1-15,共15页Hanqing Gu Bi Lian Yuxiang Yuan Ci Kong Yan Li Chang Liu Yijun Qi 
supported by the National Natural Science Foundation of China(31801074,31788103)。
Apart from their primordial role in protein synthesis,t RNAs can be cleaved to produce t RNA-derived small RNAs(ts RNAs).The biological functions of ts RNAs in plants remain largely unknown.In this study,we developed ...
关键词：tRNA-derived small RNAs small RNA sequencing RNase T2 CYP71A13 disease resistance 
Extensive profiling of the expressions of tRNAs and tRNA-derived fragments(tRFs)reveals the complexities of tRNA and tRF populations in plants被引量：7
《Science China(Life Sciences)》2021年第4期495-511,共17页Xuan Ma Chunyan Liu Xiaocong Kong Jing Liu Siju Zhang Shanshan Liang Weijiang Luan Xiaofeng Cao 
supported by the National Natural Science Foundation of China(31871321,31788103,31770874);Tianjin Natural Science Foundation of China(16JCZDJC33400);Tianjin Rice Industrial Technology System of China(ITTRRS2018006)。
Evidence is emerging that t RNA-derived fragments(t RFs)are regulatory molecules.Studies of t RFs in plants have been based on conventional small RNA sequencing,and focused on profiling of t RF-5 and t RF-3 species.A ...
关键词：TRNA tRFs tRNA halves tiny tRFs tRNA-seq 
Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response被引量：3
《Science China(Life Sciences)》2014年第2期162-170,共9页HUANG Ke LIU PengFei LI Xiang CHEN ShuBin WANG LiHui QIN Li SU ZhengHui HUANG WenHao LIU JuLi JIA Bei LIU Jie CAI JingLei PEI DuanQing PAN GuangJin 
supported by the National Basic Research Program of China,Ministry of Science and Technology(2011CB965204,2012CB966802);the National Natural Science Foundation of China(31000402);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01020401,XDA-01020202);the Ministry of Science and Technology International Technology Cooperation Program(2012DFH30050);the National Science&Technology Major Special Project on Major New Drug Innovation(2011ZX09102-010-01);the Development and Technology Innovation for Equipment Functional Development Project of Chinese Academy of Sciences(yg2011082,yg2011083)
The breakthrough development of induced pluripotent stem cells(iPSCs)raises the prospect of patient-specific treatment for many diseases through the replacement of affected cells.However,whether iPSC-derived functiona...
关键词：induced pluripotent stem cells IMMUNOGENICITY iPSC-derived neural progenitor cells 
Construction of tissue-engineered cartilage using human placenta-derived stem cells被引量：4
《Science China(Life Sciences)》2010年第2期207-214,共8页LIU DaShun1,2,HUI HuangFu3,CHAI XiangBin3,WANG BinQuan3 & QIU JianHua1 1 Department of ENT,Xijing Hospital,the Foruth Military Medical University of PLA,Xi’an 710032,China 2 Department of ENT,264 Hospital of PLA,Taiyuan 030001,China 3 Department of ENT,the First Hospital of Shanxi Medical University,Taiyuan 030001,China 
Human placenta-derived stem cells (hPDSCs) were isolated by trypsinization and further induced into cartilage cells in vitro.The engineered cartilage was constructed by combining hPDSCs with collagen sponge and the ca...
关键词：human placenta-derived stem cells COLLAGEN SPONGE CARTILAGE tissue engineering 
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