ZOL

作品数：213被引量：253H指数：7
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相关作者：赵自仙王海微杨普俞艳黄海丰更多>>
相关机构：中国科学院中南大学云南农业大学昆明医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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Biphenyl-dihydrothiazole-cyclized peptide libraries for peptide ligand and drug discovery
《Science China Chemistry》2025年第4期1434-1444,共11页Junjie Liu Xiangnan Sun Jie Zhuang Ziyan Liu Chaoying Xu Dalei Wu Chuanliu Wu 
the financial support from the National Natural Science Foundation of China(22174119 and 21974115);the Fundamental Research Funds for the Central Universities(20720210001 and 20720220005);the Program for Changjiang Scholars and Innovative Research Team in University(IRT_17R66);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(21521004)to C.Wu;the University Innovation Group Program of Jinan(202228080);the Shandong Provincial Natural Science Foundation(ZR2021JQ30);the Taishan Scholar Program of Shandong Province(tsqn201909004)to D.Wu.
Utilizing diverse organic crosslinkers for cyclization has proven to be an effective approach to creating peptide libraries;enabling the rapid discovery of functional peptides.Existing crosslinkers usually provide a t...
关键词：PEPTIDE phage display protein interaction cyclic peptide fluorescence 
Enantioselective and divergent construction of chiral amino alcohols and oxazolidin-2-ones via Ir-f-phamidol-catalyzed dynamic kinetic asymmetric hydrogenation
《Chinese Chemical Letters》2025年第3期294-298,共5页Ruixue Liu Xiaobing Ding Qiwei Lang Gen-Qiang Chen Xumu Zhang 
the National Key R&D Program of China(No.2021YFA1500201);Shenzhen Science and Technology Innovation Committee(No.KQTD20150717103157174);Stable Support Plan Program of Shenzhen Natural Science Fund(No.20200925161222002);Key-Area Research and Development Program of Guangdong Province(No.2020B010188001);Innovative Team of Universities in Guangdong Province(No.2020KCXTD016);National Natural Science Foundation of China(No.21991113);the National Natural Science Foundation of China(Nos.21901107 and 22171129);the Guangdong Basic and Applied Basic Research Foundation(2022B1515020055);Shenzhen Science and Technology Innovation Committee(No.JCYJ20210324104202007)for financial support。
The dynamic kinetic resolution(DKR)process remains a highly efficacious approach for constructing chiral amino alcohols via the catalytic asymmetric hydrogenation ofα-amino ketones.We report herein a highly efficient...
关键词：Asymmetric hydrogenation α-Amino ketone f-Phamidol Iridium-catalysed Divergent synthesis 
Zoledronate-loaded aluminum salt nanovaccines amplify cellular immune response by enhancing cross-presentation
《Nano Research》2025年第1期559-571,共13页Chunting He Penghui He Xue Tang Shuting Bai Ming Qin Yunting Zhang Zhaofei Guo Guangsheng Du Xun Sun 
supported by the National Natural Science Foundation of China(Nos.82320108020 and 81925036);the National Key Research and Development Program of China(No.2023YFC2307700);111 project(No.B18035);the Fundamental Research Funds for the Central Universities。
Being a Th2 stimulator,classic aluminum salt-based adjuvants only stimulate weak cellular immune responses that are required for vaccination against intracellular viruses or cancerous cells.As a thirdgeneration bispho...
关键词：zoledronate(ZOL) mevalonate pathway antigen cross-presentation cellular immune responses 
^(125)I标记单抗用于MDA-MB-231荷瘤鼠中PD-L1表达的SPECT显像研究
《同位素》2024年第6期568-574,共7页何淑华 汪洋 郑小北 刘玉侠 贾丽娜 张岚 
为监测肿瘤中程序性死亡蛋白配体(PD-L1)的表达水平,本研究采用Iodogen法构建了靶向PD-L1的^(125)I-Atezolizumab。考察反应时间对标记率的影响,评价其在PBS和胎牛血清中的稳定性。研究^(125)I-Atezolizumab在大鼠体内的药时曲线,乳腺癌...
关键词：程序性死亡蛋白配体1(PD-L1) ^(125)I标记 ^(125)I-Atezolizumab SPECT/CT 
High-performance imidazole-containing polymers for applications in high temperature polymer electrolyte membrane fuel cells被引量：1
《Journal of Energy Chemistry》2024年第11期512-523,共12页Tong Mu Lele Wang Qian Wang Yang Wu Patric Jannasch Jingshuai Yang 
Natural Science Foundation of China (51603031);Liaoning Provincial Natural Science Foundation of China (2020-MS-087);China Scholarship Council(202306080157)。
This work focuses on the development of high temperature polymer electrolyte membranes(HT-PEMs)as key materials for HT-PEM fuel cells(HT-PEMFCs).Recognizing the challenges associated with the phosphoric acid(PA) doped...
关键词：High temperature polymer electrolyte membrane Imidazole-containing polymer Chemical stability Fuel cell 
Multicomponent remote C(sp^(2))–H bond addition by Ru catalysis:An efficient access to the alkylarylation of 2H-imidazoles
《Chinese Chemical Letters》2024年第10期257-261,共5页Yi Luo Lin Dong 
financial support from 111 Project B18035;“the Fundamental Research Funds for the Central Universities”。
Sequential C–H bond addition with two different coupling partners is a powerful method for the rapid and modular construction of complex molecules based on simple starting materials.Herein,an efficient ruthenium-cata...
关键词：Remote C-H functionalization Multi-component reaction Ruthenium catalysis 2H-Imidazoles 
Targeting nanoplatform synergistic glutathione depletion-enhanced chemodynamic,microwave dynamic,and selective-microwave thermal to treat lung cancer bone metastasis
《Bioactive Materials》2024年第9期544-561,共18页Man Shu Jingguang Wang Ziyang Xu Teliang Lu Yue He Renshan Li Guoqing Zhong Yunbo Yan Yu Zhang Xiao Chu Jin Ke 
support from National Natural Science Foundation of China(U21A2084);National Key Research and Development Program of China(2021YFC2400704).
Once bone metastasis occurs in lung cancer,the efficiency of treatment can be greatly reduced.Current mainstream treatments are focused on inhibiting cancer cell growth and preventing bone destruction.Microwave ablati...
关键词：MgFe_(2)O_(4)@ZOL nanoparticles TARGETING Chemodynamic therapy Microwave dynamic therapy Microwave thermal therapy 
MEOX2 promotes glioma growth and temozolomide chemoresistance被引量：1
《Journal of Pharmaceutical Analysis》2024年第9期1387-1389,共3页Tengfei Li Kaijun Sun Wanchun Yang Meiling Zhang Wentao Feng Siliang Chen Mingrong Zuo Qiuyun Yuan Yanhui Liu Mina Chen 
supported by the grants from the Science and Technology Project,Technology Innovation Research and Development Project of Chengdu,China(Grant No.:2022-YF05-01456-SN);Post-Doctor Research Project,West China Hospital,Sichuan University,China(Grant No.:2021HXBH010);the Natural Science Foundation of Sichuan Province of China(Grant No.:2022NSFSC1428).
Glioblastoma(GBM)is a primary and fatal subtype of adult brain tumors.Despite standard treatments,including surgical resection and temozolomide(TMZ)chemotherapy,overall survival is only 16 months[1].Profound genomic h...
关键词：CHEMOTHERAPY resistance GLIOMA 
Mechanistic insights and improvement on the synthesis of oxazine N-Fused imidazole-2-thiones:roles of additives and solvent
《分子科学学报》2024年第3期256-266,共11页MOHAMED Hend YUAN Haiyan ZHANG Jingping 
Financial support by the National Natural Science Foundation of China(21873018,21573036,and 21603028);the Fundamental Research Funds for the Central Universities(2412019FZ010);the open project of the Jilin Province Key Laboratory of Organic Functional Molecular Design and Synthesis(130028655)are greatly acknowledged
Density functional theory(DFT)calculations are employed to disclose the detailed reaction mechanism of the synthesis of 3-phenyl-2,5-dihydro-lH-benzo[d]imidazo[5,1-b][1,3]oxazine-l-thione under unassisted,water-assist...
关键词：density functional theory reaction mechanism additives and solvent multicomponent reaction 
Imidazole-Linked Fully Conjugated Covalent Organic Framework for High-Performance Sodium-Ion Battery
《CCS Chemistry》2024年第5期1255-1263,共9页Lu Liu Yu Gong Yifan Tong Hao Tian Xubo Wang Yiming Hu Shaofeng Huang Weiwei Huang Sandeep Sharma Jingnan Cui Yinghua Jin Weitao Gong Wei Zhang 
the Natural Science Foundation of Liaoning province(grant no.2019-MS-046);W.Zhang thanks the University of Colorado Boulder for financial support of this work;W.Huang acknowledges the support from the National Natural Science Foundation of China(grant no.21875206);The authors acknowledge the assistance of the Dalian University of Technology Instrumental Analysis Center.
Covalent organic frameworks(COFs)have garnered increasing attention as promising electrode materials for sodium-ion batteries(SIBs)due to their ordered backbones,uniform pore sizes,and high surface areas.However,they ...
关键词：pyrenoimidazole fully conjugated backbones covalent organic framework electrode material sodium-ion battery 
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