supported by grants from the State Key Development Programs of China(No.2018YFA0800300 to S-MZ);the National Natural Science Foundation of China(No.31821002,31930062 to S-MZ,81872373 to JY);the Shanghai Science and Technology Development Foundation(No.20ZR1404500 to YL);the Science and Technology Research Program of Shanghai(No.19DZ2282100 to HL).
Long noncoding RNAs(lncRNAs)are known to be involved in transcriptional regulation and their deregulation is associated with the development of human diseases such as cancer.1,2 LncRNA can directly bind to purine-rich...
R-loops are RNA-DNA-hybrid-containing nucleic acids with important cellular roles.Deregulation of R-loop dynamics can lead to DNA damage and genome instability1,which has been linked to the action of endonucleases suc...
supported by the National Natural Science Foundation of China(Grant No.11564015);the Foundation of Educational Committee of Jiangxi Province,China(Grant No.GJJ211112);the Fund for Distinguished Young Scholars of Jiangxi Science&Technology Normal University(Grant No.2015QN-BJRC002)。
A-form DNA is one of the biologically active double helical structure.The study of A-DNA structure has an extensive application for developing the field of DNA packaging in biotechnology.In aqueous solution,the A-DNA ...
National Natural Science Foundation of China,Grant/Award Numbers:81802277,81872378,81802907;China Postdoctoral Science Foundation,Grant/Award Number:2018M642198;Project of Jiangsu Provincial Medical Talent,Grant/Award Number:ZDRCA2016033。
Background:Emerging evidence suggests that long noncoding RNAs(lncRNAs)play crucial roles in various cancers.In the present study,we aim to investigate the function and molecular mechanism of an up-regulated and survi...
the National Science Foundation,Chemical Measurement&Imaging Program,grant number CHE CMI 1608287.We thank A.J.Lushnikov for helping with AFM imaging.
Hybrid nucleic acid nanostructures partition architectural and functional roles between ribonucleic acid(RNA)joints and deoxyribonucleic acid(DNA)connectors.Nanoshapes self-assemble from nucleic acid modules through s...
To break through the size limitation in DNA structure assembly and to achieve the construction of DNA structures with submicrometre and micrometre scale,Fan and Yan et al.proposed a versatile DNA structure assembly st...