In a recent Nature paper,Mensah et al.demonstrate that a significant subset of frameshift mutations in C-terminal intrinsically disordered regions(IDRs)can alter phase separation propensities,cause protein mislocaliza...
Tumor-induced aberrant myelopoiesis is known to induce immunosuppressive myeloid cells in cancer patients. Han et al. reveal that tumor-induced spleen erythroblast-like cells, called Ter-cells, promote tumor growth vi...
At odds with their normal counterparts, hepatocellular carcinoma cells efficiently utilize ketone bodies to proliferate despite serum deprivation. These findings, which have been recently published in Cell Research, i...
This work was supported by the National Basic Research Program of China (2011CB944400, 2011CB710905, 2012CB944702 and 2015CB943000), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA04020202-20 and XDA04020419) and the National Natural Science Foundation of China (31200879 and 31300957).
Dear Editor, In mammalian species, the window of implantation is defined as a limited period when implantation-competent blastocyst can interact with the receptive endometrium [1]. Besides the acquisition of blastocys...
There are remarkable disparities among patients of different races with prostate cancer; however, the mechanism underlying this difference remains unclear. Here, we present a comprehensive landscape of the transcripto...
NIH 3T3 cells, a mouse fibroblast cell line used as routine target cells for transfection experiments, undergo spontaneous transformation in our experiments after they form a confluent sheet in medium containing fetal...